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    MOSMO modulator of smoothened [ Homo sapiens (human) ]

    Gene ID: 730094, updated on 22-May-2018

    Summary

    Official Symbol
    MOSMOprovided by HGNC
    Official Full Name
    modulator of smoothenedprovided by HGNC
    Primary source
    HGNC:HGNC:27087
    See related
    Ensembl:ENSG00000185716 Vega:OTTHUMG00000131587
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ATTHOG; BC030336; C16orf52
    Expression
    Ubiquitous expression in adrenal (RPKM 11.6), brain (RPKM 8.9) and 24 other tissues See more
    Orthologs

    Genomic context

    See MOSMO in Genome Data Viewer
    Location:
    16p12.2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (22008135..22084654)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (22019456..22095975)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ubiquinol-cytochrome c reductase core protein 2 Neighboring gene cell division cycle associated 8 pseudogene Neighboring gene PDZ domain containing 9 Neighboring gene islet cell autoantigen 1, 69kDa pseudogene Neighboring gene uncharacterized LOC105371129 Neighboring gene von Willebrand factor A domain containing 3A Neighboring gene short chain dehydrogenase/reductase family 42E, member 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    General gene information

    Markers

    Homology

    Clone Names

    • MGC26782

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    negative regulation of smoothened signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of neuron differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of protein stability ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    ciliary membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    modulator of smoothened protein
    Names
    Attenuator of Hedgehog
    uncharacterized protein C16orf52

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164579.1NP_001158051.1  modulator of smoothened protein

      See identical proteins and their annotated locations for NP_001158051.1

      Status: VALIDATED

      Source sequence(s)
      AC009019, AC092119
      Consensus CDS
      CCDS58431.1
      UniProtKB/Swiss-Prot
      Q8NHV5
      Related
      ENSP00000454926.1, OTTHUMP00000253683, ENST00000542527.6, OTTHUMT00000430039
      Conserved Domains (1) summary
      cl00562
      Location:62160
      Cyt_bd_oxida_I; Cytochrome bd terminal oxidase subunit I

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

      Range
      22008135..22084654
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p12 PATCHES

    Genomic

    1. NW_017852933.1 Reference GRCh38.p12 PATCHES

      Range
      1020384..1096903 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_173501.1: Suppressed sequence

      Description
      NM_173501.1: This RefSeq was permanently suppressed because currently there is support for the transcript, but not for the protein, and it is a candidate for nonsense-mediated decay.
    2. NR_024104.1: Suppressed sequence

      Description
      NR_024104.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
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