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    LAMA1 laminin subunit alpha 1 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 722472, updated on 3-Apr-2017

    Summary

    Gene symbol
    LAMA1
    Gene description
    laminin subunit alpha 1
    See related
    Ensembl:ENSMMUG00000011408
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs

    Genomic context

    See LAMA1 in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    63
    Annotation release Status Assembly Chr Location
    102 current Mmul_8.0.1 (GCF_000772875.2) 18 NC_027910.1 (2471096..2639119)
    Build 1.2 previous assembly Mmul_051212 (GCF_000002255.3) 18 NC_007875.1 (7189022..7356756)

    Chromosome 18 - NC_027910.1Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 30 Neighboring gene solute carrier family 25 member 51-like Neighboring gene uncharacterized LOC106994418 Neighboring gene uncharacterized LOC106994419 Neighboring gene Rho GTPase activating protein 28 Neighboring gene 60S ribosomal protein L7-like 1 pseudogene

    Genomic regions, transcripts, and products

    Pathways from BioSystems

    • Amoebiasis, organism-specific biosystem (from KEGG)
      Amoebiasis, organism-specific biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
    • Amoebiasis, conserved biosystem (from KEGG)
      Amoebiasis, conserved biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
    • ECM-receptor interaction, organism-specific biosystem (from KEGG)
      ECM-receptor interaction, organism-specific biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
    • ECM-receptor interaction, conserved biosystem (from KEGG)
      ECM-receptor interaction, conserved biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
    • Focal adhesion, organism-specific biosystem (from KEGG)
      Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, conserved biosystem (from KEGG)
      Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
      PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
      PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Small cell lung cancer, organism-specific biosystem (from KEGG)
      Small cell lung cancer, organism-specific biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
    • Small cell lung cancer, conserved biosystem (from KEGG)
      Small cell lung cancer, conserved biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
    • Toxoplasmosis, organism-specific biosystem (from KEGG)
      Toxoplasmosis, organism-specific biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
    • Toxoplasmosis, conserved biosystem (from KEGG)
      Toxoplasmosis, conserved biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...

    General gene information

    Markers

    Homology

    General protein information

    Preferred Names
    laminin subunit alpha-1
    Names
    laminin, alpha 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 102 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_8.0.1 Primary Assembly

    Genomic

    1. NC_027910.1 Reference Mmul_8.0.1 Primary Assembly

      Range
      2471096..2639119
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015121568.1XP_014977054.1  laminin subunit alpha-1 isoform X1

      Conserved Domains (12) summary
      smart00136
      Location:20272
      LamNT; Laminin N-terminal domain (domain VI)
      smart00281
      Location:12171348
      LamB; Laminin B domain
      smart00282
      Location:21452284
      LamG; Laminin G domain
      cd00055
      Location:852904
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00110
      Location:23112467
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00052
      Location:572700
      Laminin_B; Laminin B (Domain IV)
      pfam00053
      Location:906952
      Laminin_EGF; Laminin EGF domain
      pfam00054
      Location:27572886
      Laminin_G_1; Laminin G domain
      pfam06008
      Location:15711834
      Laminin_I; Laminin Domain I
      pfam06009
      Location:20152149
      Laminin_II; Laminin Domain II
      pfam16043
      Location:17301884
      DUF4795; Domain of unknown function (DUF4795)
      cl12013
      Location:16061781
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    2. XM_001118617.3XP_001118617.3  laminin subunit alpha-1 isoform X2

      UniProtKB/TrEMBL
      F6VZB6
      Related
      ENSMMUP00000014966.3, ENSMMUT00000015970.3
      Conserved Domains (12) summary
      smart00136
      Location:20272
      LamNT; Laminin N-terminal domain (domain VI)
      smart00281
      Location:12171348
      LamB; Laminin B domain
      smart00282
      Location:21452284
      LamG; Laminin G domain
      cd00055
      Location:852904
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00110
      Location:23112467
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00052
      Location:572700
      Laminin_B; Laminin B (Domain IV)
      pfam00053
      Location:906952
      Laminin_EGF; Laminin EGF domain
      pfam00054
      Location:27472876
      Laminin_G_1; Laminin G domain
      pfam06008
      Location:15711834
      Laminin_I; Laminin Domain I
      pfam06009
      Location:20152149
      Laminin_II; Laminin Domain II
      pfam16043
      Location:17301884
      DUF4795; Domain of unknown function (DUF4795)
      cl12013
      Location:16061781
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
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