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    Gdpd2 glycerophosphodiester phosphodiesterase domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 71584, updated on 20-May-2018

    Summary

    Official Symbol
    Gdpd2provided by MGI
    Official Full Name
    glycerophosphodiester phosphodiesterase domain containing 2provided by MGI
    Primary source
    MGI:MGI:1918834
    See related
    Ensembl:ENSMUSG00000019359 Vega:OTTMUSG00000018299
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gde3; Obdpf; 9130017L10Rik
    Summary
    This gene encodes a member of the glycerophosphodiester phosphodiesterase enzyme family. The encoded protein hydrolyzes glycerophosphoinositol to produce inositol 1-phosphate and glycerol. Overexpression of this gene is associated with activity-dependent actin cytoskeleton disorganization. The encoded protein may negatively regulate growth rate and induce differentiation of osteoblasts. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
    Expression
    Biased expression in spleen adult (RPKM 33.6), duodenum adult (RPKM 20.7) and 13 other tissues See more
    Orthologs

    Genomic context

    See Gdpd2 in Genome Data Viewer
    Location:
    X; X C3
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) X NC_000086.7 (100729835..100738901)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (97925186..97934238)

    Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene PDZ domain containing 11 Neighboring gene kinesin family member 4 Neighboring gene predicted gene 14902 Neighboring gene discs large MAGUK scaffold protein 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    glycerophosphodiester phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
     
    glycerophosphoinositol inositolphosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphoric diester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    actin filament reorganization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of osteoblast differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of osteoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    actin filament IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    glycerophosphoinositol inositolphosphodiesterase GDPD2
    Names
    glycerophosphodiester phosphodiesterase 3
    osteoblast differentiation promoting factor
    NP_001292870.1
    NP_076097.1
    XP_006528358.1
    XP_006528360.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305941.1NP_001292870.1  glycerophosphoinositol inositolphosphodiesterase GDPD2

      See identical proteins and their annotated locations for NP_001292870.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK018634, AK086508, BE948924
      Consensus CDS
      CCDS30306.1
      UniProtKB/Swiss-Prot
      Q9ESM6
      Related
      ENSMUSP00000109373.1, OTTMUSP00000020002, ENSMUST00000113744.1, OTTMUST00000044501
      Conserved Domains (1) summary
      cl14615
      Location:198500
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    2. NM_001358507.1NP_001345436.1  glycerophosphoinositol inositolphosphodiesterase GDPD2

      Status: REVIEWED

      Source sequence(s)
      BE948924, BX005480
      Conserved Domains (1) summary
      cl14615
      Location:198500
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    3. NM_023608.4NP_076097.1  glycerophosphoinositol inositolphosphodiesterase GDPD2

      See identical proteins and their annotated locations for NP_076097.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK018634, BB844010, BE948924, BX005480
      Consensus CDS
      CCDS30306.1
      UniProtKB/Swiss-Prot
      Q9ESM6
      Related
      ENSMUSP00000019503.7, OTTMUSP00000019876, ENSMUST00000019503.13, OTTMUST00000044210
      Conserved Domains (1) summary
      cl14615
      Location:198500
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000086.7 Reference GRCm38.p4 C57BL/6J

      Range
      100729835..100738901
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006528297.3XP_006528360.1  glycerophosphoinositol inositolphosphodiesterase GDPD2 isoform X2

      Conserved Domains (2) summary
      pfam03009
      Location:26267
      GDPD; Glycerophosphoryl diester phosphodiesterase family
      cl14615
      Location:4296
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    2. XM_006528295.1XP_006528358.1  glycerophosphoinositol inositolphosphodiesterase GDPD2 isoform X1

      UniProtKB/Swiss-Prot
      Q9ESM6
      Conserved Domains (1) summary
      cl14615
      Location:198500
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
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