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    TNFAIP1 TNF alpha induced protein 1 [ Homo sapiens (human) ]

    Gene ID: 7126, updated on 5-Sep-2021

    Summary

    Official Symbol
    TNFAIP1provided by HGNC
    Official Full Name
    TNF alpha induced protein 1provided by HGNC
    Primary source
    HGNC:HGNC:11894
    See related
    Ensembl:ENSG00000109079 MIM:191161
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    B12; B61; EDP1; BTBD34; hBACURD2
    Summary
    This gene was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells. Studies of a similar gene in mouse suggest that the expression of this gene is developmentally regulated in a tissue-specific manner. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in lung (RPKM 21.1), spleen (RPKM 20.2) and 25 other tissues See more
    Orthologs
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    Genomic context

    See TNFAIP1 in Genome Data Viewer
    Location:
    17q11.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (28335671..28347009)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (26662787..26674035)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene keratin 18 pseudogene 55 Neighboring gene transmembrane protein 97 Neighboring gene intraflagellar transport 20 Neighboring gene DNA polymerase delta interacting protein 2 Neighboring gene transmembrane protein 199 Neighboring gene microRNA 4723 Neighboring gene SEBOX homeobox

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Meta-analysis of genome-wide association studies identifies two loci associated with circulating osteoprotegerin levels.
    GeneReviews: Not available

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC2317

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cyclin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small GTPase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of Cul3-RING ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2
    Names
    BTB/POZ domain-containing protein TNFAIP1
    tumor necrosis factor, alpha induced protein 1
    tumor necrosis factor, alpha-induced protein 1 (endothelial)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021137.5NP_066960.1  BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2

      See identical proteins and their annotated locations for NP_066960.1

      Status: REVIEWED

      Source sequence(s)
      BC003694
      Consensus CDS
      CCDS11227.1
      UniProtKB/Swiss-Prot
      Q13829
      Related
      ENSP00000226225.2, ENST00000226225.7
      Conserved Domains (1) summary
      cd18401
      Location:26129
      BTB_POZ_TNFAIP1_BACURD2; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in tumor necrosis factor, alpha-induced protein 1, endothelial (TNFAIP1)

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

      Range
      28335671..28347009
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017024993.2XP_016880482.1  BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 isoform X1

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