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    TLE2 TLE family member 2, transcriptional corepressor [ Homo sapiens (human) ]

    Gene ID: 7089, updated on 12-May-2019

    Summary

    Official Symbol
    TLE2provided by HGNC
    Official Full Name
    TLE family member 2, transcriptional corepressorprovided by HGNC
    Primary source
    HGNC:HGNC:11838
    See related
    Ensembl:ENSG00000065717 MIM:601041
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ESG; ESG2; GRG2
    Expression
    Ubiquitous expression in salivary gland (RPKM 17.9), fat (RPKM 13.6) and 24 other tissues See more
    Orthologs

    Genomic context

    See TLE2 in Genome Data Viewer
    Location:
    19p13.3
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (2997638..3047635, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (2997636..3047846, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 77 Neighboring gene TLE family member 6, subcortical maternal complex member Neighboring gene uncharacterized LOC105372242 Neighboring gene TLE family member 5, transcriptional modulator

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Deactivation of the beta-catenin transactivating complex, organism-specific biosystem (from REACTOME)
      Deactivation of the beta-catenin transactivating complex, organism-specific biosystemThe mechanisms involved in downregulation of TCF-dependent transcription are not yet very well understood. beta-catenin is known to recruit a number of transcriptional repressors, including Reptin, S...
    • Degradation of beta-catenin by the destruction complex, organism-specific biosystem (from REACTOME)
      Degradation of beta-catenin by the destruction complex, organism-specific biosystemThe beta-catenin destruction complex plays a key role in the canonical Wnt signaling pathway. In the absence of Wnt signaling, this complex controls the levels of cytoplamic beta-catenin. Beta-cateni...
    • Formation of the beta-catenin:TCF transactivating complex, organism-specific biosystem (from REACTOME)
      Formation of the beta-catenin:TCF transactivating complex, organism-specific biosystemOnce in the nucleus, beta-catenin is recruited to WNT target genes through interaction with TCF/LEF transcription factors. This family, which consists of TCF7 (also known as TCF1), TCF7L1 (also known...
    • NOTCH1 Intracellular Domain Regulates Transcription, organism-specific biosystem (from REACTOME)
      NOTCH1 Intracellular Domain Regulates Transcription, organism-specific biosystemNICD1 produced by activation of NOTCH1 in response to Delta and Jagged ligands (DLL/JAG) presented in trans, traffics to the nucleus where it acts as a transcription regulator. In the nucleus, NICD1 ...
    • Regulation of Wnt-mediated beta catenin signaling and target gene transcription, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of Wnt-mediated beta catenin signaling and target gene transcription, organism-specific biosystem
      Regulation of Wnt-mediated beta catenin signaling and target gene transcription
    • Repression of WNT target genes, organism-specific biosystem (from REACTOME)
      Repression of WNT target genes, organism-specific biosystemIn the absence of a WNT signal, many WNT target genes are repressed by Groucho/TLE. Groucho was initially identified in Drosophila, where it has been shown to interact with a variety of proteins to ...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by NOTCH, organism-specific biosystem (from REACTOME)
      Signaling by NOTCH, organism-specific biosystemThe Notch Signaling Pathway (NSP) is a highly conserved pathway for cell-cell communication. NSP is involved in the regulation of cellular differentiation, proliferation, and specification. For exam...
    • Signaling by NOTCH1, organism-specific biosystem (from REACTOME)
      Signaling by NOTCH1, organism-specific biosystemNOTCH1 functions as both a transmembrane receptor presented on the cell surface and as a transcriptional regulator in the nucleus.NOTCH1 receptor presented on the plasma membrane is activated by a me...
    • Signaling by Wnt, organism-specific biosystem (from REACTOME)
      Signaling by Wnt, organism-specific biosystemWNT signaling pathways control a wide range of developmental and adult process in metozoans including cell proliferation, cell fate decisions, cell polarity and stem cell maintenance (reviewed in Sai...
    • TCF dependent signaling in response to WNT, organism-specific biosystem (from REACTOME)
      TCF dependent signaling in response to WNT, organism-specific biosystem19 WNT ligands and 10 FZD receptors have been identified in human cells; interactions amongst these ligands and receptors vary in a developmental and tissue-specific manner and lead to activation of ...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ41188

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    repressing transcription factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    animal organ morphogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    beta-catenin-TCF complex assembly TAS
    Traceable Author Statement
    more info
     
    negative regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular space HDA PubMed 
    focal adhesion IDA
    Inferred from Direct Assay
    more info
     
    nuclear body IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
     
    transcription factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    transducin-like enhancer protein 2
    Names
    enhancer of split groucho-like protein 2
    transducin like enhancer of split 2
    transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)
    transducin-like enhancer of split 2, homolog of Drosophila E(sp1)

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001144761.1NP_001138233.1  transducin-like enhancer protein 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences compared to variant 4, one of which results in a frameshift. This results in a shorter isoform (2) with distinct N- and C-termini compared to isoform 4.
      Source sequence(s)
      AK308137, BC017364
      Consensus CDS
      CCDS45913.1
      UniProtKB/Swiss-Prot
      Q04725
      Related
      ENSP00000468279.1, ENST00000591529.5
      Conserved Domains (4) summary
      COG2319
      Location:469693
      WD40; WD40 repeat [General function prediction only]
      pfam03920
      Location:18141
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:474513
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:463631
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. NM_001144762.1NP_001138234.1  transducin-like enhancer protein 2 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and has multiple coding region differences compared to variant 4. This results in a shorter isoform (2) with a shorter N-terminus compared to isoform 4.
      Source sequence(s)
      AK293407, BC017364
      Consensus CDS
      CCDS45912.1
      UniProtKB/Swiss-Prot
      Q04725
      Related
      ENSP00000392427.2, ENST00000443826.7
      Conserved Domains (4) summary
      COG2319
      Location:333619
      WD40; WD40 repeat [General function prediction only]
      pfam03920
      Location:168
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:338377
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:334618
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    3. NM_001300846.1NP_001287775.1  transducin-like enhancer protein 2 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (4).
      Source sequence(s)
      AK312285, BC017364, HY046309, HY140405
      Consensus CDS
      CCDS74255.1
      UniProtKB/Swiss-Prot
      Q04725
      UniProtKB/TrEMBL
      K7EMK7
      Related
      ENSP00000466542.1, ENST00000590536.5
      Conserved Domains (4) summary
      COG2319
      Location:456742
      WD40; WD40 repeat [General function prediction only]
      pfam03920
      Location:1128
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:461500
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:457741
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    4. NM_003260.5NP_003251.2  transducin-like enhancer protein 2 isoform 1

      See identical proteins and their annotated locations for NP_003251.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) uses an alternate in-frame splice site in the 5' coding region, compared to variant 4. It encodes isoform 1, which is shorter by an amino acid, compared to isoform 4.
      Source sequence(s)
      AC011549, AW262763, BC017364
      Consensus CDS
      CCDS45911.1
      UniProtKB/Swiss-Prot
      Q04725
      Related
      ENSP00000262953.5, ENST00000262953.11
      Conserved Domains (4) summary
      sd00039
      Location:460499
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:1132
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      cl25539
      Location:456740
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cl26464
      Location:126366
      Atrophin-1; Atrophin-1 family

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

      Range
      2997638..3047635 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011528230.1XP_011526532.1  transducin-like enhancer protein 2 isoform X1

      Conserved Domains (4) summary
      COG2319
      Location:444730
      WD40; WD40 repeat [General function prediction only]
      pfam03920
      Location:1128
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:449488
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:445729
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. XM_006722864.2XP_006722927.1  transducin-like enhancer protein 2 isoform X2

      Conserved Domains (4) summary
      COG2319
      Location:456680
      WD40; WD40 repeat [General function prediction only]
      pfam03920
      Location:1128
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:461500
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:450618
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
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