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    Iyd iodotyrosine deiodinase [ Mus musculus (house mouse) ]

    Gene ID: 70337, updated on 28-Jun-2018

    Summary

    Official Symbol
    Iydprovided by MGI
    Official Full Name
    iodotyrosine deiodinaseprovided by MGI
    Primary source
    MGI:MGI:1917587
    See related
    Ensembl:ENSMUSG00000019762 Vega:OTTMUSG00000027509
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    IYD-1; Dehal1; AI265638; 0610009A07Rik
    Expression
    Biased expression in liver adult (RPKM 19.2), kidney adult (RPKM 11.0) and 9 other tissues See more
    Orthologs

    Genomic context

    See Iyd in Genome Data Viewer
    Location:
    10; 10 A1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (3540279..3554877)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (6791664..6806262, complement)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 29987 Neighboring gene predicted gene, 30033 Neighboring gene RIKEN cDNA A330032P22 gene Neighboring gene predicted gene, 30164 Neighboring gene pleckstrin homology domain containing, family G (with RhoGef domain) member 1 Neighboring gene mitochondrial ribosomal protein S36 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    FMN binding ISO
    Inferred from Sequence Orthology
    more info
     
    iodide peroxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    iodide peroxidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    iodide peroxidase activity ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    oxidoreductase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    oxidation-reduction process ISO
    Inferred from Sequence Orthology
    more info
     
    thyroid hormone metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    thyroid hormone metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    tyrosine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    tyrosine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasmic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    iodotyrosine deiodinase 1
    Names
    iodotyrosine dehalogenase 1 protein
    NP_081667.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027391.4NP_081667.1  iodotyrosine deiodinase 1 precursor

      See identical proteins and their annotated locations for NP_081667.1

      Status: VALIDATED

      Source sequence(s)
      AC153571, AC155833
      Consensus CDS
      CCDS56670.1
      UniProtKB/Swiss-Prot
      Q9DCX8
      Related
      ENSMUSP00000019896.4, OTTMUSP00000034362, ENSMUST00000019896.4
      Conserved Domains (1) summary
      cd02144
      Location:89281
      iodotyrosine_dehalogenase; Iodotyrosine dehalogenase catalyzes the removal of iodine from the 3, 5 positions of L-tyosine in thyroid, liver and kidney, using NADPH as electron donor. This enzyme is a homolog of the nitroreductase family. These enzymes are usually homodimers.

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      3540279..3554877
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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