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    TESK1 testis associated actin remodelling kinase 1 [ Homo sapiens (human) ]

    Gene ID: 7016, updated on 3-Jun-2018
    Official Symbol
    TESK1provided by HGNC
    Official Full Name
    testis associated actin remodelling kinase 1provided by HGNC
    Primary source
    HGNC:HGNC:11731
    See related
    Ensembl:ENSG00000107140 MIM:601782; Vega:OTTHUMG00000019863
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain and a C-terminal proline-rich domain. Its protein kinase domain is most closely related to those of the LIM motif-containing protein kinases (LIMKs). The encoded protein can phosphorylate myelin basic protein and histone in vitro. The testicular germ cell-specific expression and developmental pattern of expression of the mouse gene suggests that this gene plays an important role at and after the meiotic phase of spermatogenesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
    Expression
    Ubiquitous expression in fat (RPKM 24.9), testis (RPKM 24.6) and 25 other tissues See more
    Orthologs
    See TESK1 in Genome Data Viewer
    Location:
    9p13.3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 9 NC_000009.12 (35605284..35610041)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (35605281..35610038)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene RUN and SH3 domain containing 2 Neighboring gene family with sequence similarity 166 member B Neighboring gene ribosomal protein S29 pseudogene 17 Neighboring gene microRNA 4667 Neighboring gene CD72 molecule Neighboring gene uncharacterized LOC101926948 Neighboring gene signaling threshold regulating transmembrane adaptor 1

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein C-terminus binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine/tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    negative regulation of protein autophosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    negative regulation of protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of stress fiber assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    positive regulation of stress fiber assembly TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of protein localization ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    colocalizes_with cytoplasmic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    dual specificity testis-specific protein kinase 1
    Names
    testicular protein kinase 1
    testis-specific kinase 1
    NP_001305159.1
    NP_006276.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001318230.1NP_001305159.1  dual specificity testis-specific protein kinase 1 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AL357874, BC011799, BC067130
      UniProtKB/Swiss-Prot
      Q15569
      Conserved Domains (1) summary
      cl21453
      Location:46158
      PKc_like; Protein Kinases, catalytic domain
    2. NM_006285.2NP_006276.2  dual specificity testis-specific protein kinase 1 isoform 1

      See identical proteins and their annotated locations for NP_006276.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AF507907, BC011799, BC067130
      Consensus CDS
      CCDS6580.1
      UniProtKB/Swiss-Prot
      Q15569
      UniProtKB/TrEMBL
      Q8NFJ4
      Related
      ENSP00000338127.5, OTTHUMP00000021332, ENST00000336395.5, OTTHUMT00000052314
      Conserved Domains (2) summary
      smart00219
      Location:61311
      TyrKc; Tyrosine kinase, catalytic domain
      cd14155
      Location:63318
      PKc_TESK; Catalytic domain of the Dual-specificity protein kinase, Testicular protein kinase

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p12 Primary Assembly

      Range
      35605284..35610041
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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