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    BSG basigin (Ok blood group) [ Homo sapiens (human) ]

    Gene ID: 682, updated on 19-Sep-2021

    Summary

    Official Symbol
    BSGprovided by HGNC
    Official Full Name
    basigin (Ok blood group)provided by HGNC
    Primary source
    HGNC:HGNC:1116
    See related
    Ensembl:ENSG00000172270 MIM:109480
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OK; 5F7; TCSF; CD147; EMPRIN; HAb18G; EMMPRIN; SLC7A11
    Summary
    The protein encoded by this gene, basigin, is a plasma membrane protein that is important in spermatogenesis, embryo implantation, neural network formation, and tumor progression. Basigin is also a member of the immunoglobulin superfamily, ubiquitously expressed in various tissues. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2020]
    Expression
    Ubiquitous expression in heart (RPKM 230.6), colon (RPKM 194.1) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See BSG in Genome Data Viewer
    Location:
    19p13.3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (571283..583493)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (571283..583493)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene granzyme M Neighboring gene CRISPRi-validated cis-regulatory element chr19.73 Neighboring gene BSG antisense RNA 1 Neighboring gene Rho GTPase activating protein 33 pseudogene Neighboring gene hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 Neighboring gene uncharacterized LOC107987266

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp160, precursor env The functional interaction between CD98 and CD147 is involved in the regulation of HIV-1 gp160-mediated cell fusion PubMed
    Tat tat Application of HIV-1 Tat transmembrane transport peptide to cells induces PKN1 gene and slightly represses two genes, ZCD1 and BSG PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cadherin binding HDA PubMed 
    enables cell-cell adhesion mediator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables mannose binding IEA
    Inferred from Electronic Annotation
    more info
     
    NOT enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables virus receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cell surface receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in decidualization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in dendrite self-avoidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in embryo implantation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in neutrophil chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in odontogenesis of dentin-containing tooth IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein localization to plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to cAMP IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to mercury ion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to peptide hormone IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in viral entry into host cell IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Golgi membrane TAS
    Traceable Author Statement
    more info
     
    located_in acrosomal membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in focal adhesion HDA PubMed 
    located_in integral component of plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    located_in melanosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane HDA PubMed 
    located_in membrane raft IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in photoreceptor inner segment IEA
    Inferred from Electronic Annotation
    more info
     
    located_in photoreceptor outer segment IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in sarcolemma IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    basigin
    Names
    OK blood group antigen
    collagenase stimulatory factor
    extracellular matrix metalloproteinase inducer
    hepatoma-associated antigen
    leukocyte activation antigen M6
    tumor cell-derived collagenase stimulatory factor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007468.1 RefSeqGene

      Range
      6272..17169
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_816

    mRNA and Protein(s)

    1. NM_001322243.2NP_001309172.1  basigin isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), as well as variant 2, encodes isoform 2.
      Source sequence(s)
      AC009005, CB153773, GU557064
      Consensus CDS
      CCDS12034.1
      UniProtKB/Swiss-Prot
      P35613
      UniProtKB/TrEMBL
      Q54A51
      Conserved Domains (1) summary
      smart00409
      Location:112202
      IG; Immunoglobulin
    2. NM_001728.4NP_001719.2  basigin isoform 1 precursor

      See identical proteins and their annotated locations for NP_001719.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AY358113, GU557064
      Consensus CDS
      CCDS12033.1
      UniProtKB/Swiss-Prot
      P35613
      Related
      ENSP00000333769.3, ENST00000333511.9
      Conserved Domains (3) summary
      cd00096
      Location:40114
      Ig; Immunoglobulin domain
      smart00410
      Location:228318
      IG_like; Immunoglobulin like
      cl11960
      Location:219317
      Ig; Immunoglobulin domain
    3. NM_198589.3NP_940991.1  basigin isoform 2 precursor

      See identical proteins and their annotated locations for NP_940991.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. Variants 2 and 5 both encode the same isoform (2).
      Source sequence(s)
      AB085790, GU557064
      Consensus CDS
      CCDS12034.1
      UniProtKB/Swiss-Prot
      P35613
      UniProtKB/TrEMBL
      Q54A51
      Related
      ENSP00000343809.4, ENST00000353555.9
      Conserved Domains (1) summary
      smart00409
      Location:112202
      IG; Immunoglobulin
    4. NM_198590.3NP_940992.1  basigin isoform 3

      See identical proteins and their annotated locations for NP_940992.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      DA007913, GU557064
      Consensus CDS
      CCDS58635.1
      UniProtKB/Swiss-Prot
      P35613
      Related
      ENSP00000473664.1, ENST00000545507.6
      Conserved Domains (2) summary
      smart00410
      Location:19109
      IG_like; Immunoglobulin like
      cd00096
      Location:1115
      Ig; Ig strand A [structural motif]
    5. NM_198591.4NP_940993.2  basigin isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC009005, GU557065
      Consensus CDS
      CCDS12032.1
      Related
      ENSP00000344707.4, ENST00000346916.9
      Conserved Domains (2) summary
      smart00410
      Location:19109
      IG_like; Immunoglobulin like
      cd00096
      Location:1115
      Ig; Ig strand A [structural motif]

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

      Range
      571283..583493
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017027173.2XP_016882662.1  basigin isoform X1

      UniProtKB/Swiss-Prot
      P35613
      Conserved Domains (3) summary
      cd00096
      Location:40114
      Ig; Immunoglobulin domain
      smart00410
      Location:228318
      IG_like; Immunoglobulin like
      cl11960
      Location:219317
      Ig; Immunoglobulin domain
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