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    Apool apolipoprotein O-like [ Mus musculus (house mouse) ]

    Gene ID: 68117, updated on 18-Apr-2019

    Summary

    Official Symbol
    Apoolprovided by MGI
    Official Full Name
    apolipoprotein O-likeprovided by MGI
    Primary source
    MGI:MGI:1915367
    See related
    Ensembl:ENSMUSG00000025525
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Micos27; 6720473G16Rik; 9430083G14Rik; E130106L15Rik
    Expression
    Broad expression in placenta adult (RPKM 9.6), CNS E11.5 (RPKM 9.4) and 22 other tissues See more
    Orthologs

    Genomic context

    See Apool in Genome Data Viewer
    Location:
    X; X E1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) X NC_000086.7 (112311352..112372755)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (109425017..109486039)

    Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4933403O08 gene Neighboring gene barrier to autointegration factor 1 pseudogene Neighboring gene spermidine/spermine N1-acetyl transferase-like 1 Neighboring gene ubinuclein 2 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    cristae formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    MICOS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    MICOS complex ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial inner membrane HDA PubMed 
    mitochondrion HDA PubMed 
    mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    MICOS complex subunit Mic27

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313733.1NP_001300662.1  MICOS complex subunit Mic27 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice junction at the 3' end of the first exon and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AI132704, AK012398, DV061158
      Conserved Domains (1) summary
      pfam09769
      Location:37174
      ApoO; Apolipoprotein O
    2. NM_001313734.1NP_001300663.1  MICOS complex subunit Mic27 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two in-frame exons compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AI132704, AI587915, AK012398, DV061158
      Consensus CDS
      CCDS85799.1
      UniProtKB/TrEMBL
      B1AV14
      Related
      ENSMUSP00000109042.1, ENSMUST00000113415.1
      Conserved Domains (1) summary
      pfam09769
      Location:7121
      ApoO; Apolipoprotein O
    3. NM_026565.3NP_080841.1  MICOS complex subunit Mic27 isoform 1 precursor

      See identical proteins and their annotated locations for NP_080841.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AI132704, AK012398, DV061158
      Consensus CDS
      CCDS30359.1
      UniProtKB/Swiss-Prot
      Q78IK4
      Related
      ENSMUSP00000026599.3, ENSMUST00000026599.9
      Conserved Domains (1) summary
      pfam09769
      Location:42179
      ApoO; Apolipoprotein O

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000086.7 Reference GRCm38.p4 C57BL/6J

      Range
      112311352..112372755
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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