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    STX5 syntaxin 5 [ Homo sapiens (human) ]

    Gene ID: 6811, updated on 5-Sep-2021

    Summary

    Official Symbol
    STX5provided by HGNC
    Official Full Name
    syntaxin 5provided by HGNC
    Primary source
    HGNC:HGNC:11440
    See related
    Ensembl:ENSG00000162236 MIM:603189
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SED5; STX5A
    Summary
    This gene encodes a member of the syntaxin or t-SNARE (target-SNAP receptor) family. These proteins are found on cell membranes and serve as the targets for v-SNAREs (vesicle-SNAP receptors), permitting specific synaptic vesicle docking and fusion. The encoded protein regulates endoplasmic reticulum to Golgi transport and plays a critical role in autophagy. Autoantibodies targeting the encoded protein may be a diagnostic marker for endometriosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
    Expression
    Ubiquitous expression in thyroid (RPKM 22.3), ovary (RPKM 17.5) and 25 other tissues See more
    Orthologs
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    Genomic context

    See STX5 in Genome Data Viewer
    Location:
    11q12.3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (62806860..62832053, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (62574332..62599523, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene transmembrane protein 179B Neighboring gene transmembrane protein 223 Neighboring gene microRNA 6514 Neighboring gene nuclear RNA export factor 1 Neighboring gene RNA, U6 small nuclear 118, pseudogene Neighboring gene STX5 divergent transcript Neighboring gene WD repeat domain 74 Neighboring gene RNA, U2 small nuclear 2, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of syntaxin 5 (STX5) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables SNAP receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables cadherin binding HDA PubMed 
    enables protein N-terminus binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Golgi disassembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in early endosome to Golgi transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of Golgi organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in retrograde transport, endosome to Golgi IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in vesicle docking IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in vesicle fusion with Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in ER to Golgi transport vesicle membrane TAS
    Traceable Author Statement
    more info
     
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in Golgi membrane TAS
    Traceable Author Statement
    more info
     
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of SNARE complex TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    located_in endoplasmic reticulum-Golgi intermediate compartment membrane TAS
    Traceable Author Statement
    more info
     
    is_active_in integral component of membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    syntaxin-5
    Names
    syntaxin 5A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_030034.1 RefSeqGene

      Range
      5041..30232
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001244666.3NP_001231595.1  syntaxin-5 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift and early stop codon compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      BC002645, CB155395
      Consensus CDS
      CCDS58140.1
      UniProtKB/Swiss-Prot
      Q13190
      Related
      ENSP00000367129.4, ENST00000377897.8
      Conserved Domains (3) summary
      COG5325
      Location:94301
      COG5325; t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion]
      pfam11416
      Location:5374
      Syntaxin-5_N; Syntaxin-5 N-terminal, Sly1p-binding domain
      cl22856
      Location:266304
      SNARE; SNARE motif
    2. NM_001330294.2NP_001317223.1  syntaxin-5 isoform 3

      Status: REVIEWED

      Source sequence(s)
      BE409085, BI820950, BT019647, BX537426
      Consensus CDS
      CCDS81578.1
      UniProtKB/Swiss-Prot
      Q13190
      Related
      ENSP00000378182.1, ENST00000394690.5
      Conserved Domains (3) summary
      COG5325
      Location:128270
      COG5325; t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion]
      cd15844
      Location:212284
      SNARE_syntaxin5; SNARE motif of syntaxin 5
      pfam11416
      Location:120
      Syntaxin-5_N; Syntaxin-5 N-terminal, Sly1p-binding domain
    3. NM_003164.5NP_003155.2  syntaxin-5 isoform 1

      See identical proteins and their annotated locations for NP_003155.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).
      Source sequence(s)
      BE409085, CB155395, U26648
      Consensus CDS
      CCDS8038.2
      UniProtKB/Swiss-Prot
      Q13190
      Related
      ENSP00000294179.3, ENST00000294179.8
      Conserved Domains (3) summary
      COG5325
      Location:182324
      COG5325; t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion]
      cd15844
      Location:266338
      SNARE_syntaxin5; SNARE motif of syntaxin 5
      pfam11416
      Location:5374
      Syntaxin-5_N; Syntaxin-5 N-terminal, Sly1p-binding domain

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

      Range
      62806860..62832053 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011545224.3XP_011543526.1  syntaxin-5 isoform X1

      See identical proteins and their annotated locations for XP_011543526.1

      UniProtKB/TrEMBL
      B4DKR0
      Conserved Domains (2) summary
      cd15844
      Location:170242
      SNARE_syntaxin5; SNARE motif of syntaxin 5
      cl26014
      Location:86228
      SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
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