Format

Send to:

Choose Destination
    • Showing Current items.

    Rnls renalase, FAD-dependent amine oxidase [ Mus musculus (house mouse) ]

    Gene ID: 67795, updated on 20-Mar-2018

    Summary

    Official Symbol
    Rnlsprovided by MGI
    Official Full Name
    renalase, FAD-dependent amine oxidaseprovided by MGI
    Primary source
    MGI:MGI:1915045
    See related
    Ensembl:ENSMUSG00000071573 Vega:OTTMUSG00000033116
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI452315; AW060440; C10orf59; 6530404N21Rik
    Expression
    Biased expression in testis adult (RPKM 47.5), adrenal adult (RPKM 5.9) and 7 other tissues See more
    Orthologs

    Genomic context

    See Rnls in Genome Data Viewer
    Location:
    19; 19 C1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 19 NC_000085.6 (33137744..33392295, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (33212234..33466785, complement)

    Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 29863 Neighboring gene predicted gene, 29946 Neighboring gene microRNA 3970 Neighboring gene cullin 1 pseudogene Neighboring gene predicted gene, 29998 Neighboring gene predicted gene 7237 Neighboring gene 39S ribosomal protein L33, mitochondrial pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    NADH binding ISO
    Inferred from Sequence Orthology
    more info
     
    epinephrine binding ISO
    Inferred from Sequence Orthology
    more info
     
    monoamine oxidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    oxidoreductase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    oxidoreductase activity, acting on NAD(P)H ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cardiac left ventricle morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dopamine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    epinephrine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heart contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of heart rate ISO
    Inferred from Sequence Orthology
    more info
     
    norepinephrine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    oxidation-reduction process ISO
    Inferred from Sequence Orthology
    more info
     
    phosphate ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of systemic arterial blood pressure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to norepinephrine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to salt ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    renalase
    Names
    MAO-C
    alpha-NAD(P)H oxidase/anomerase
    mMAO-C
    monoamine oxidase-C
    rnls
    NP_001139814.2
    NP_001161290.1
    XP_017173777.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001146342.2NP_001139814.2  renalase isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to variant 1.
      Source sequence(s)
      AC160088, BC052355
      Consensus CDS
      CCDS50415.1
      UniProtKB/Swiss-Prot
      A7RDN6
      UniProtKB/TrEMBL
      E9Q243
      Related
      ENSMUSP00000127592.1, ENSMUST00000163093.1
      Conserved Domains (1) summary
      COG3380
      Location:2182
      COG3380; Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]
    2. NM_001167818.1NP_001161290.1  renalase isoform 1

      See identical proteins and their annotated locations for NP_001161290.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC160088, BC052355
      Consensus CDS
      CCDS50416.1
      UniProtKB/Swiss-Prot
      A7RDN6
      UniProtKB/TrEMBL
      A0A0R4J156
      Related
      ENSMUSP00000093825.5, OTTMUSP00000044412, ENSMUST00000096114.11, OTTMUST00000082781
      Conserved Domains (2) summary
      COG3380
      Location:10300
      COG3380; Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]
      cl21454
      Location:67184
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000085.6 Reference GRCm38.p4 C57BL/6J

      Range
      33137744..33392295 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017318288.1XP_017173777.1  renalase isoform X1

    Support Center