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    Loxl4 lysyl oxidase-like 4 [ Mus musculus (house mouse) ]

    Gene ID: 67573, updated on 23-May-2018

    Summary

    Official Symbol
    Loxl4provided by MGI
    Official Full Name
    lysyl oxidase-like 4provided by MGI
    Primary source
    MGI:MGI:1914823
    See related
    Ensembl:ENSMUSG00000025185 Vega:OTTMUSG00000035803
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Loxc; 4833426I20Rik
    Expression
    Broad expression in limb E14.5 (RPKM 3.3), bladder adult (RPKM 3.2) and 19 other tissues See more
    Orthologs

    Genomic context

    See Loxl4 in Genome Data Viewer
    Location:
    19; 19 C3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 19 NC_000085.6 (42592279..42612806, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (42666769..42687296, complement)

    Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 41851 Neighboring gene R3H domain and coiled-coil containing 1 like Neighboring gene pyridine nucleotide-disulphide oxidoreductase domain 2 Neighboring gene uncharacterized LOC102637646 Neighboring gene uncharacterized LOC102637720 Neighboring gene HPS1, biogenesis of lysosomal organelles complex 3 subunit 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    copper ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor IEA
    Inferred from Electronic Annotation
    more info
     
    protein-lysine 6-oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein-lysine 6-oxidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    scavenger receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    collagen fibril organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    peptidyl-lysine oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    receptor complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    lysyl oxidase homolog 4
    Names
    lysyl oxidase-like protein 4
    lysyl oxidase-related protein C

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164311.1NP_001157783.1  lysyl oxidase homolog 4 isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC124552, AK014331, BC053925, BY145829
      Consensus CDS
      CCDS50441.1
      UniProtKB/TrEMBL
      E9Q600, Q8CEU1
      Related
      ENSMUSP00000125803.1, OTTMUSP00000050536, ENSMUST00000164786.7, OTTMUST00000091707
      Conserved Domains (3) summary
      smart00202
      Location:33133
      SR; Scavenger receptor Cys-rich
      pfam00530
      Location:42133
      SRCR; Scavenger receptor cysteine-rich domain
      pfam01186
      Location:535730
      Lysyl_oxidase; Lysyl oxidase
    2. NM_053083.3NP_444313.3  lysyl oxidase homolog 4 isoform 2 precursor

      See identical proteins and their annotated locations for NP_444313.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the middle portion of the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC124552, AK014331, BC053925, BY145829
      Consensus CDS
      CCDS29830.1
      UniProtKB/Swiss-Prot
      Q924C6
      UniProtKB/TrEMBL
      Q8CEU1
      Related
      ENSMUSP00000026190.7, OTTMUSP00000050518, ENSMUST00000026190.13, OTTMUST00000091682
      Conserved Domains (3) summary
      smart00202
      Location:33133
      SR; Scavenger receptor Cys-rich
      pfam00530
      Location:42133
      SRCR; Scavenger receptor cysteine-rich domain
      pfam01186
      Location:534729
      Lysyl_oxidase; Lysyl oxidase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000085.6 Reference GRCm38.p4 C57BL/6J

      Range
      42592279..42612806 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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