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    Ears2 glutamyl-tRNA synthetase 2, mitochondrial [ Mus musculus (house mouse) ]

    Gene ID: 67417, updated on 23-May-2018

    Summary

    Official Symbol
    Ears2provided by MGI
    Official Full Name
    glutamyl-tRNA synthetase 2, mitochondrialprovided by MGI
    Primary source
    MGI:MGI:1914667
    See related
    Ensembl:ENSMUSG00000030871 Vega:OTTMUSG00000025467
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1970; 3230401I01Rik
    Summary
    This gene encodes a putative member of the class I family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of glutamate to tRNA molecules. Mutations in a similar gene in human have been associated with combined oxidative phosphorylation deficiency 12 (COXPD12). [provided by RefSeq, Mar 2015]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 4.5), ovary adult (RPKM 3.9) and 28 other tissues See more
    Orthologs

    Genomic context

    See Ears2 in Genome Data Viewer
    Location:
    7; 7 F2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (122034162..122067086, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (129182335..129210577, complement)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene component of oligomeric golgi complex 7 Neighboring gene golgi associated, gamma adaptin ear containing, ARF binding protein 2 Neighboring gene ubiquitin family domain containing 1 Neighboring gene NADH:ubiquinone oxidoreductase subunit AB1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1) 

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    glutamate-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    glutamate-tRNA ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    glutamate-tRNA(Gln) ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    tRNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    glutamyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    glutamyl-tRNA aminoacylation ISO
    Inferred from Sequence Orthology
    more info
     
    tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
     
    tRNA aminoacylation for mitochondrial protein translation ISO
    Inferred from Sequence Orthology
    more info
     
    tRNA aminoacylation for protein translation IEA
    Inferred from Electronic Annotation
    more info
     
    translation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion HDA PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    probable glutamate--tRNA ligase, mitochondrial
    Names
    gluRS
    glutamate--tRNA ligase
    glutamyl-tRNA synthetase 2 (mitochondrial)(putative)
    probable glutamyl-tRNA synthetase, mitochondrial
    NP_080416.1
    XP_006508189.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026140.3NP_080416.1  probable glutamate--tRNA ligase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_080416.1

      Status: REVIEWED

      Source sequence(s)
      AC124379, AK014324, AK167506, AW495609, BY122579
      Consensus CDS
      CCDS21807.1
      UniProtKB/Swiss-Prot
      Q9CXJ1
      Related
      ENSMUSP00000033159.3, OTTMUSP00000030963, ENSMUST00000033159.3, OTTMUST00000062703
      Conserved Domains (2) summary
      cd00808
      Location:37361
      GluRS_core; catalytic core domain of discriminating glutamyl-tRNA synthetase
      PRK01406
      Location:36521
      gltX; glutamyl-tRNA synthetase; Reviewed

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      122034162..122067086 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508126.3XP_006508189.1  probable glutamate--tRNA ligase, mitochondrial isoform X1

      Conserved Domains (2) summary
      cd00808
      Location:37361
      GluRS_core; catalytic core domain of discriminating glutamyl-tRNA synthetase
      PRK01406
      Location:36417
      gltX; glutamyl-tRNA synthetase; Reviewed
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