Format

Send to:

Choose Destination
    • Showing Current items.

    SRP54 signal recognition particle 54 [ Homo sapiens (human) ]

    Gene ID: 6729, updated on 8-Jul-2018
    Official Symbol
    SRP54provided by HGNC
    Official Full Name
    signal recognition particle 54provided by HGNC
    Primary source
    HGNC:HGNC:11301
    See related
    Ensembl:ENSG00000100883 MIM:604857; Vega:OTTHUMG00000140214
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Ubiquitous expression in testis (RPKM 26.2), thyroid (RPKM 18.4) and 25 other tissues See more
    Orthologs
    See SRP54 in Genome Data Viewer
    Location:
    14q13.2
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 14 NC_000014.9 (34982898..35029567)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (35451901..35498773)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene bromodomain adjacent to zinc finger domain 1A Neighboring gene vegetative cell wall protein gp1-like Neighboring gene SRP54 antisense RNA 1 (head to head) Neighboring gene immunoglobulin (CD79A) binding protein 1 pseudogene 1 Neighboring gene family with sequence similarity 177 member A1 Neighboring gene uncharacterized LOC101927178 Neighboring gene protein phosphatase 2 regulatory subunit B''gamma Neighboring gene KIAA0391

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Rev rev HIV-1 Rev interacting protein, signal recognition particle 54kDa (SRP54), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed

    Go to the HIV-1, Human Interaction Database

    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
    • Protein export, organism-specific biosystem (from KEGG)
      Protein export, organism-specific biosystemThe protein export is the active transport of proteins from the cytoplasm to the exterior of the cell, or to the periplasmic compartment in Gram-negative bacteria. The sec dependent pathway is the ge...
    • Protein export, conserved biosystem (from KEGG)
      Protein export, conserved biosystemThe protein export is the active transport of proteins from the cytoplasm to the exterior of the cell, or to the periplasmic compartment in Gram-negative bacteria. The sec dependent pathway is the ge...
    • SRP-dependent cotranslational protein targeting to membrane, organism-specific biosystem (from REACTOME)
      SRP-dependent cotranslational protein targeting to membrane, organism-specific biosystemThe process for translation of a protein destined for the endoplasmic reticulum (ER) branches from the canonical cytoslic translation process at the point when a nascent polypeptide containing a hydr...
    • Translation, organism-specific biosystem (from REACTOME)
      Translation, organism-specific biosystemProtein synthesis is accomplished through the process of translation of an mRNA sequence into a polypeptide chain. This process can be divided into three distinct stages: initiation, elongation and ...
    • mRNA Processing, organism-specific biosystem (from WikiPathways)
      mRNA Processing, organism-specific biosystemThis process describes the conversion of precursor messenger RNA into mature messenger RNA (mRNA). The pre-mRNA molecule undergoes three main modifications. These modifications are 5' capping, 3' po...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    7S RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    GDP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    GTP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA binding HDA PubMed 
    drug binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum signal peptide binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ribonucleoprotein complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    nuclear speck IEA
    Inferred from Electronic Annotation
    more info
     
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    signal recognition particle, endoplasmic reticulum targeting IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    signal recognition particle 54 kDa protein
    Names
    signal recognition particle 54kD
    signal recognition particle 54kDa

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001146282.1NP_001139754.1  signal recognition particle 54 kDa protein isoform 2

      See identical proteins and their annotated locations for NP_001139754.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks a portion of the 5' coding region and uses a distinct translational start codon, compared to variant 1. The resulting isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AK300824, BC000652, DA495064
      Consensus CDS
      CCDS53893.1
      UniProtKB/Swiss-Prot
      P61011
      Related
      ENSP00000440629.1, ENST00000546080.5
      Conserved Domains (1) summary
      cl27330
      Location:8381
      FlhF; Flagellar biosynthesis GTPase FlhF [Cell motility]
    2. NM_003136.3NP_003127.1  signal recognition particle 54 kDa protein isoform 1

      See identical proteins and their annotated locations for NP_003127.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC000652, DA495064
      Consensus CDS
      CCDS9652.1
      UniProtKB/Swiss-Prot
      P61011
      Related
      ENSP00000216774.6, ENST00000216774.10
      Conserved Domains (1) summary
      TIGR01425
      Location:2430
      SRP54_euk; signal recognition particle protein SRP54

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p12 Primary Assembly

      Range
      34982898..35029567
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005268024.3XP_005268081.1  signal recognition particle 54 kDa protein isoform X2

      Conserved Domains (1) summary
      cl27330
      Location:2385
      FlhF; Flagellar biosynthesis GTPase FlhF [Cell motility]
    2. XM_017021615.2XP_016877104.1  signal recognition particle 54 kDa protein isoform X3

      Conserved Domains (2) summary
      pfam00448
      Location:1190
      SRP54; SRP54-type protein, GTPase domain
      pfam02978
      Location:222325
      SRP_SPB; Signal peptide binding domain
    3. XM_011537106.1XP_011535408.1  signal recognition particle 54 kDa protein isoform X1

      See identical proteins and their annotated locations for XP_011535408.1

      UniProtKB/Swiss-Prot
      P61011
      Conserved Domains (1) summary
      TIGR01425
      Location:2430
      SRP54_euk; signal recognition particle protein SRP54
    Support Center