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    Ddx18 DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 [ Mus musculus (house mouse) ]

    Gene ID: 66942, updated on 5-Aug-2018

    Summary

    Official Symbol
    Ddx18provided by MGI
    Official Full Name
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 18provided by MGI
    Primary source
    MGI:MGI:1914192
    See related
    Ensembl:ENSMUSG00000001674 Vega:OTTMUSG00000019928
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2310005B10Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 25.0), liver E14 (RPKM 19.5) and 28 other tissues See more
    Orthologs

    Genomic context

    See Ddx18 in Genome Data Viewer
    Location:
    1; 1 E2.3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (121553835..121567980, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (123450412..123464557, complement)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 93 Neighboring gene 5-hydroxytryptamine (serotonin) receptor 5B Neighboring gene DnaJ (Hsp40) homolog, subfamily C, member 10 pseudogene Neighboring gene guanosine diphosphate (GDP) dissociation inhibitor 2 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC117904

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    chromosome ISO
    Inferred from Sequence Orthology
    more info
     
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ATP-dependent RNA helicase DDX18
    Names
    DEAD box protein 18
    NP_080136.2
    XP_006529857.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025860.3NP_080136.2  ATP-dependent RNA helicase DDX18

      See identical proteins and their annotated locations for NP_080136.2

      Status: VALIDATED

      Source sequence(s)
      BC103776, BY084565, BY381480
      Consensus CDS
      CCDS15240.1
      UniProtKB/Swiss-Prot
      Q8K363
      UniProtKB/TrEMBL
      B2RUM8
      Related
      ENSMUSP00000001724.5, OTTMUSP00000021484, ENSMUST00000001724.11, OTTMUST00000047501
      Conserved Domains (5) summary
      smart00487
      Location:184372
      DEXDc; DEAD-like helicases superfamily
      cd00079
      Location:390519
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cd00268
      Location:169376
      DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
      pfam05177
      Location:50157
      RCSD; RCSD region
      pfam13959
      Location:551609
      DUF4217; Domain of unknown function (DUF4217)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      121553835..121567980 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529794.3XP_006529857.1  ATP-dependent RNA helicase DDX18 isoform X1

      Conserved Domains (4) summary
      smart00487
      Location:112300
      DEXDc; DEAD-like helicases superfamily
      cd00079
      Location:318447
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cd00268
      Location:97304
      DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
      pfam13959
      Location:479537
      DUF4217; Domain of unknown function (DUF4217)
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