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    SPP2 secreted phosphoprotein 2 [ Homo sapiens (human) ]

    Gene ID: 6694, updated on 3-Jun-2018

    Summary

    Official Symbol
    SPP2provided by HGNC
    Official Full Name
    secreted phosphoprotein 2provided by HGNC
    Primary source
    HGNC:HGNC:11256
    See related
    Ensembl:ENSG00000072080 MIM:602637; Vega:OTTHUMG00000059208
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SPP24; SPP-24
    Summary
    This gene encodes a secreted phosphoprotein that is a member of the cystatin superfamily. [provided by RefSeq, Oct 2008]
    Expression
    Restricted expression toward liver (RPKM 29.9) See more
    Orthologs

    Genomic context

    See SPP2 in Genome Data Viewer
    Location:
    2q37.1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (234050667..234077134)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (234959346..234985776)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene MSL complex subunit 3 pseudogene 1 Neighboring gene transient receptor potential cation channel subfamily M member 8 Neighboring gene uncharacterized LOC105373932 Neighboring gene uncharacterized LOC105373933

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits.
    NHGRI GWA Catalog

    Pathways from BioSystems

    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    • Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
      Platelet activation, signaling and aggregation, organism-specific biosystemPlatelet activation begins with the initial binding of adhesive ligands and of the excitatory platelet agonists (released or generated at the sites of vascular trauma) to cognate receptors on the pla...
    • Platelet degranulation, organism-specific biosystem (from REACTOME)
      Platelet degranulation, organism-specific biosystemPlatelets function as exocytotic cells, secreting a plethora of effector molecules at sites of vascular injury. Platelets contain a number of distinguishable storage granules including alpha granules...
    • Response to elevated platelet cytosolic Ca2+, organism-specific biosystem (from REACTOME)
      Response to elevated platelet cytosolic Ca2+, organism-specific biosystemActivation of phospholipase C enzymes results in the generation of second messengers of the phosphatidylinositol pathway. The events resulting from this pathway are a rise in intracellular calcium an...

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    endopeptidase inhibitor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    bone remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    cellular protein metabolic process TAS
    Traceable Author Statement
    more info
     
    negative regulation of endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    platelet degranulation TAS
    Traceable Author Statement
    more info
     
    post-translational protein modification TAS
    Traceable Author Statement
    more info
     
    skeletal system development TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    collagen-containing extracellular matrix HDA PubMed 
    endoplasmic reticulum lumen TAS
    Traceable Author Statement
    more info
     
    extracellular region TAS
    Traceable Author Statement
    more info
     
    platelet dense granule lumen TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    secreted phosphoprotein 24
    Names
    secreted phosphoprotein 2, 24kD
    secreted phosphoprotein 2, 24kDa

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008668.1 RefSeqGene

      Range
      5001..31431
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_006944.2NP_008875.1  secreted phosphoprotein 24 precursor

      See identical proteins and their annotated locations for NP_008875.1

      Status: REVIEWED

      Source sequence(s)
      AJ308099
      Consensus CDS
      CCDS2511.1
      UniProtKB/Swiss-Prot
      Q13103
      Related
      ENSP00000168148.3, OTTHUMP00000065381, ENST00000168148.7, OTTHUMT00000131313
      Conserved Domains (1) summary
      pfam07448
      Location:73211
      Spp-24; Secreted phosphoprotein 24 (Spp-24)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

      Range
      234050667..234077134
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011511699.3XP_011510001.1  secreted phosphoprotein 24 isoform X1

      See identical proteins and their annotated locations for XP_011510001.1

      UniProtKB/Swiss-Prot
      Q13103
      Related
      ENSP00000362466.1, OTTHUMP00000065382, ENST00000373368.5
      Conserved Domains (1) summary
      pfam07448
      Location:73211
      Spp-24; Secreted phosphoprotein 24 (Spp-24)
    2. XM_005246102.4XP_005246159.1  secreted phosphoprotein 24 isoform X1

      See identical proteins and their annotated locations for XP_005246159.1

      UniProtKB/Swiss-Prot
      Q13103
      Conserved Domains (1) summary
      pfam07448
      Location:73211
      Spp-24; Secreted phosphoprotein 24 (Spp-24)
    3. XM_011511698.2XP_011510000.1  secreted phosphoprotein 24 isoform X1

      See identical proteins and their annotated locations for XP_011510000.1

      UniProtKB/Swiss-Prot
      Q13103
      Conserved Domains (1) summary
      pfam07448
      Location:73211
      Spp-24; Secreted phosphoprotein 24 (Spp-24)
    4. XM_011511700.3XP_011510002.1  secreted phosphoprotein 24 isoform X1

      See identical proteins and their annotated locations for XP_011510002.1

      UniProtKB/Swiss-Prot
      Q13103
      Conserved Domains (1) summary
      pfam07448
      Location:73211
      Spp-24; Secreted phosphoprotein 24 (Spp-24)
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