Format

Send to:

Choose Destination
    • Showing Current items.

    Tanc1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 66860, updated on 9-Sep-2018

    Summary

    Official Symbol
    Tanc1provided by MGI
    Official Full Name
    tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1provided by MGI
    Primary source
    MGI:MGI:1914110
    See related
    Ensembl:ENSMUSG00000035168 Vega:OTTMUSG00000012709
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tanc; mKIAA1728; 1200003E16Rik
    Expression
    Ubiquitous expression in ovary adult (RPKM 4.4), lung adult (RPKM 3.7) and 28 other tissues See more
    Orthologs

    Genomic context

    See Tanc1 in Genome Data Viewer
    Location:
    2; 2 C1.1
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (59598965..59846213)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (59450101..59684206)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39831 Neighboring gene mitochondrial ribosomal protein S18B pseudogene Neighboring gene predicted gene, 32976 Neighboring gene WD repeat, SAM and U-box domain containing 1 Neighboring gene bromodomain adjacent to zinc finger domain, 2B Neighboring gene predicted gene 13572

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    dendritic spine maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    myoblast fusion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of postsynapse organization ISO
    Inferred from Sequence Orthology
    more info
     
    visual learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    axon terminus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    postsynaptic density, intracellular component ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    synapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    protein TANC1
    Names
    TPR domain, ankyrin-repeat and coiled-coil-containing protein
    tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290659.1NP_001277588.1  protein TANC1 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a. The 5' UTR of this variant is incomplete due to a lack of full-length transcript support and splice pattern ambiguity in the upstream region.
      Source sequence(s)
      AK031162, AK079966, BC079914, BY753173, CX769146
      Consensus CDS
      CCDS71057.1
      UniProtKB/Swiss-Prot
      Q0VGY8
      UniProtKB/TrEMBL
      E9QAF9
      Conserved Domains (8) summary
      cd00204
      Location:10991221
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00006
      Location:12821307
      TPR; TPR repeat [structural motif]
      pfam12796
      Location:11061198
      Ank_2; Ankyrin repeats (3 copies)
      pfam13191
      Location:375417
      AAA_16; AAA ATPase domain
      pfam13414
      Location:12801357
      TPR_11; TPR repeat
      pfam13428
      Location:13611403
      TPR_14; Tetratricopeptide repeat
      pfam13637
      Location:928978
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:11351165
      ANK; ANK repeat [structural motif]
    2. NM_198294.3NP_938036.2  protein TANC1 isoform a

      See identical proteins and their annotated locations for NP_938036.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a). The 5'-most non-coding exon of this variant is inferred based on partial transcript alignments.
      Source sequence(s)
      AK031162, AK079966, BC079914, BY753173, CX769146
      Consensus CDS
      CCDS16054.1
      UniProtKB/Swiss-Prot
      Q0VGY8
      Related
      ENSMUSP00000036003.4, ENSMUST00000037526.10
      Conserved Domains (8) summary
      cd00204
      Location:11061228
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00006
      Location:12891314
      TPR; TPR repeat [structural motif]
      pfam12796
      Location:11131205
      Ank_2; Ankyrin repeats (3 copies)
      pfam13191
      Location:382424
      AAA_16; AAA ATPase domain
      pfam13414
      Location:12871364
      TPR_11; TPR repeat
      pfam13428
      Location:13681410
      TPR_14; Tetratricopeptide repeat
      pfam13637
      Location:935985
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:11421172
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      59598965..59846213
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319201.1XP_017174690.1  protein TANC1 isoform X1

      Conserved Domains (8) summary
      cd00204
      Location:11241246
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00006
      Location:13071332
      TPR; TPR repeat [structural motif]
      pfam12796
      Location:11311223
      Ank_2; Ankyrin repeats (3 copies)
      pfam13191
      Location:400442
      AAA_16; AAA ATPase domain
      pfam13414
      Location:13051382
      TPR_11; TPR repeat
      pfam13428
      Location:13861428
      TPR_14; Tetratricopeptide repeat
      pfam13637
      Location:9531003
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:11601190
      ANK; ANK repeat [structural motif]
    2. XM_017319203.1XP_017174692.1  protein TANC1 isoform X1

      Conserved Domains (8) summary
      cd00204
      Location:11241246
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00006
      Location:13071332
      TPR; TPR repeat [structural motif]
      pfam12796
      Location:11311223
      Ank_2; Ankyrin repeats (3 copies)
      pfam13191
      Location:400442
      AAA_16; AAA ATPase domain
      pfam13414
      Location:13051382
      TPR_11; TPR repeat
      pfam13428
      Location:13861428
      TPR_14; Tetratricopeptide repeat
      pfam13637
      Location:9531003
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:11601190
      ANK; ANK repeat [structural motif]
    3. XM_017319200.1XP_017174689.1  protein TANC1 isoform X1

      Conserved Domains (8) summary
      cd00204
      Location:11241246
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00006
      Location:13071332
      TPR; TPR repeat [structural motif]
      pfam12796
      Location:11311223
      Ank_2; Ankyrin repeats (3 copies)
      pfam13191
      Location:400442
      AAA_16; AAA ATPase domain
      pfam13414
      Location:13051382
      TPR_11; TPR repeat
      pfam13428
      Location:13861428
      TPR_14; Tetratricopeptide repeat
      pfam13637
      Location:9531003
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:11601190
      ANK; ANK repeat [structural motif]
    4. XM_006500037.3XP_006500100.1  protein TANC1 isoform X2

      Conserved Domains (8) summary
      cd00204
      Location:11171239
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00006
      Location:13001325
      TPR; TPR repeat [structural motif]
      pfam12796
      Location:11241216
      Ank_2; Ankyrin repeats (3 copies)
      pfam13191
      Location:393435
      AAA_16; AAA ATPase domain
      pfam13414
      Location:12981375
      TPR_11; TPR repeat
      pfam13428
      Location:13791421
      TPR_14; Tetratricopeptide repeat
      pfam13637
      Location:946996
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:11531183
      ANK; ANK repeat [structural motif]
    5. XM_017319205.1XP_017174694.1  protein TANC1 isoform X3

      UniProtKB/TrEMBL
      E9QAF9
      Related
      ENSMUSP00000108187.1, OTTMUSP00000013632, ENSMUST00000112568.7, OTTMUST00000030323
      Conserved Domains (8) summary
      cd00204
      Location:10991221
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00006
      Location:12821307
      TPR; TPR repeat [structural motif]
      pfam12796
      Location:11061198
      Ank_2; Ankyrin repeats (3 copies)
      pfam13191
      Location:375417
      AAA_16; AAA ATPase domain
      pfam13414
      Location:12801357
      TPR_11; TPR repeat
      pfam13428
      Location:13611403
      TPR_14; Tetratricopeptide repeat
      pfam13637
      Location:928978
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:11351165
      ANK; ANK repeat [structural motif]
    6. XM_006500034.3XP_006500097.1  protein TANC1 isoform X1

      See identical proteins and their annotated locations for XP_006500097.1

      Conserved Domains (8) summary
      cd00204
      Location:11241246
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00006
      Location:13071332
      TPR; TPR repeat [structural motif]
      pfam12796
      Location:11311223
      Ank_2; Ankyrin repeats (3 copies)
      pfam13191
      Location:400442
      AAA_16; AAA ATPase domain
      pfam13414
      Location:13051382
      TPR_11; TPR repeat
      pfam13428
      Location:13861428
      TPR_14; Tetratricopeptide repeat
      pfam13637
      Location:9531003
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:11601190
      ANK; ANK repeat [structural motif]
    7. XM_017319204.1XP_017174693.1  protein TANC1 isoform X1

      Conserved Domains (8) summary
      cd00204
      Location:11241246
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00006
      Location:13071332
      TPR; TPR repeat [structural motif]
      pfam12796
      Location:11311223
      Ank_2; Ankyrin repeats (3 copies)
      pfam13191
      Location:400442
      AAA_16; AAA ATPase domain
      pfam13414
      Location:13051382
      TPR_11; TPR repeat
      pfam13428
      Location:13861428
      TPR_14; Tetratricopeptide repeat
      pfam13637
      Location:9531003
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:11601190
      ANK; ANK repeat [structural motif]
    8. XM_017319202.1XP_017174691.1  protein TANC1 isoform X1

      Conserved Domains (8) summary
      cd00204
      Location:11241246
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00006
      Location:13071332
      TPR; TPR repeat [structural motif]
      pfam12796
      Location:11311223
      Ank_2; Ankyrin repeats (3 copies)
      pfam13191
      Location:400442
      AAA_16; AAA ATPase domain
      pfam13414
      Location:13051382
      TPR_11; TPR repeat
      pfam13428
      Location:13861428
      TPR_14; Tetratricopeptide repeat
      pfam13637
      Location:9531003
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:11601190
      ANK; ANK repeat [structural motif]
    9. XM_006500035.3XP_006500098.1  protein TANC1 isoform X1

      See identical proteins and their annotated locations for XP_006500098.1

      Conserved Domains (8) summary
      cd00204
      Location:11241246
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00006
      Location:13071332
      TPR; TPR repeat [structural motif]
      pfam12796
      Location:11311223
      Ank_2; Ankyrin repeats (3 copies)
      pfam13191
      Location:400442
      AAA_16; AAA ATPase domain
      pfam13414
      Location:13051382
      TPR_11; TPR repeat
      pfam13428
      Location:13861428
      TPR_14; Tetratricopeptide repeat
      pfam13637
      Location:9531003
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:11601190
      ANK; ANK repeat [structural motif]
    10. XM_006500036.3XP_006500099.1  protein TANC1 isoform X1

      See identical proteins and their annotated locations for XP_006500099.1

      Conserved Domains (8) summary
      cd00204
      Location:11241246
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00006
      Location:13071332
      TPR; TPR repeat [structural motif]
      pfam12796
      Location:11311223
      Ank_2; Ankyrin repeats (3 copies)
      pfam13191
      Location:400442
      AAA_16; AAA ATPase domain
      pfam13414
      Location:13051382
      TPR_11; TPR repeat
      pfam13428
      Location:13861428
      TPR_14; Tetratricopeptide repeat
      pfam13637
      Location:9531003
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:11601190
      ANK; ANK repeat [structural motif]
    11. XM_006500039.3XP_006500102.1  protein TANC1 isoform X4

      Conserved Domains (7) summary
      cd00204
      Location:9061028
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00006
      Location:10891114
      TPR; TPR repeat [structural motif]
      pfam12796
      Location:9131005
      Ank_2; Ankyrin repeats (3 copies)
      pfam13414
      Location:10871164
      TPR_11; TPR repeat
      pfam13428
      Location:11681210
      TPR_14; Tetratricopeptide repeat
      pfam13637
      Location:735785
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:942972
      ANK; ANK repeat [structural motif]
    12. XM_006500040.3XP_006500103.1  protein TANC1 isoform X5

      Conserved Domains (7) summary
      cd00204
      Location:802924
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00006
      Location:9851010
      TPR; TPR repeat [structural motif]
      pfam12796
      Location:809901
      Ank_2; Ankyrin repeats (3 copies)
      pfam13414
      Location:9831060
      TPR_11; TPR repeat
      pfam13428
      Location:10641106
      TPR_14; Tetratricopeptide repeat
      pfam13637
      Location:631681
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:838868
      ANK; ANK repeat [structural motif]
    Support Center