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    SNRPG small nuclear ribonucleoprotein polypeptide G [ Homo sapiens (human) ]

    Gene ID: 6637, updated on 7-Oct-2018

    Summary

    Official Symbol
    SNRPGprovided by HGNC
    Official Full Name
    small nuclear ribonucleoprotein polypeptide Gprovided by HGNC
    Primary source
    HGNC:HGNC:11163
    See related
    Ensembl:ENSG00000143977 MIM:603542; Vega:OTTHUMG00000129670
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SMG; Sm-G
    Summary
    The protein encoded by this gene is a component of the U1, U2, U4, and U5 small nuclear ribonucleoprotein complexes, precursors of the spliceosome. The encoded protein may also be a part of the U7 small nuclear ribonucleoprotein complex, which participates in the processing of the 3' end of histone transcripts. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
    Expression
    Ubiquitous expression in colon (RPKM 14.7), appendix (RPKM 13.1) and 25 other tissues See more
    Orthologs

    Genomic context

    See SNRPG in Genome Data Viewer
    Location:
    2p13.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (70281362..70293771, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (70508510..70520869, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L39 pseudogene 15 Neighboring gene prenylcysteine oxidase 1 Neighboring gene family with sequence similarity 136 member A Neighboring gene bromodomain containing 7 pseudogene 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
    NHGRI GWA Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Rev rev HIV-1 Rev interacting protein, small nuclear ribonucleoprotein polypeptide G (SNRPG), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with SNRPG is increased by RRE PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC117317

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA binding HDA PubMed 
    contributes_to RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    RNA splicing TAS
    Traceable Author Statement
    more info
    PubMed 
    histone mRNA metabolic process TAS
    Traceable Author Statement
    more info
     
    import into nucleus TAS
    Traceable Author Statement
    more info
     
    mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    PubMed 
    mRNA splicing, via spliceosome TAS
    Traceable Author Statement
    more info
     
    spliceosomal complex assembly NAS
    Non-traceable Author Statement
    more info
    PubMed 
    spliceosomal snRNP assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    spliceosomal snRNP assembly TAS
    Traceable Author Statement
    more info
     
    termination of RNA polymerase II transcription TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    P granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    SMN-Sm protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    SMN-Sm protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    U1 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    U1 snRNP IDA
    Inferred from Direct Assay
    more info
    PubMed 
    U12-type spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    U12-type spliceosomal complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    U2 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    U2-type prespliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    U4 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    U4 snRNP IDA
    Inferred from Direct Assay
    more info
    PubMed 
    U5 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    U7 snRNP IDA
    Inferred from Direct Assay
    more info
    PubMed 
    catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    catalytic step 2 spliceosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    methylosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    small nuclear ribonucleoprotein complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    spliceosomal complex TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    small nuclear ribonucleoprotein G
    Names
    sm protein G
    snRNP-G
    NP_001304094.1
    NP_001304095.1
    NP_001304096.1
    NP_001304097.1
    NP_001304098.1
    NP_001304100.1
    NP_003087.1
    XP_016860263.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001317165.1NP_001304094.1  small nuclear ribonucleoprotein G isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate internal exon compared to variant 1, that causes a frameshift. The resulting isoform (b) has a longer and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AC079338, AI742299, AV682126, BP424287, DW428820
      Consensus CDS
      CCDS82463.1
      UniProtKB/TrEMBL
      C9JVQ0
      Related
      ENSP00000393388.1, OTTHUMP00000204047, ENST00000454893.1, OTTHUMT00000331513
      Conserved Domains (1) summary
      cd01719
      Location:560
      Sm_G; Sm protein G
    2. NM_001317166.1NP_001304095.1  small nuclear ribonucleoprotein G isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is 1 aa shorter compared to isoform a.
      Source sequence(s)
      AC079338, AI742299, AV682126, BU540400
      Conserved Domains (1) summary
      cd01719
      Location:573
      Sm_G; Sm protein G
    3. NM_001317167.1NP_001304096.1  small nuclear ribonucleoprotein G isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate exon in place of the first exon compared to variant 1. The resulting isoform (d) has a shorter and distinct N-terminus compared to isoform a.
      Source sequence(s)
      AI290354, AI742299
      Consensus CDS
      CCDS82462.1
      UniProtKB/TrEMBL
      F5H013
      Related
      ENSP00000416334.2, OTTHUMP00000204050, ENST00000413456.6, OTTHUMT00000331518
      Conserved Domains (1) summary
      cd01719
      Location:466
      Sm_G; Sm protein G
    4. NM_001317168.1NP_001304097.1  small nuclear ribonucleoprotein G isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate exon in place of the first exon compared to variant 1. The resulting isoform (e) is shorter at the N-terminus compared to isoform a. Variants 5 and 6 both encode the same isoform (e).
      Source sequence(s)
      AI742299, BC035103, HY168189
      Consensus CDS
      CCDS82461.1
      UniProtKB/TrEMBL
      Q49AN9
      Related
      ENSP00000441332.1, OTTHUMP00000237246, ENST00000482975.6, OTTHUMT00000331512
      Conserved Domains (1) summary
      cd01719
      Location:162
      Sm_G; Sm protein G
    5. NM_001317169.1NP_001304098.1  small nuclear ribonucleoprotein G isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) contains two alternate exons in place of the first exon compared to variant 1. The resulting isoform (e) is shorter at the N-terminus compared to isoform a. Variants 5 and 6 both encode the same isoform (e).
      Source sequence(s)
      AC079338, AI742299, HY168189
      Consensus CDS
      CCDS82461.1
      UniProtKB/TrEMBL
      Q49AN9
      Related
      ENSP00000402194.1, OTTHUMP00000204048, ENST00000438261.5, OTTHUMT00000331514
      Conserved Domains (1) summary
      cd01719
      Location:162
      Sm_G; Sm protein G
    6. NM_001317171.1NP_001304100.1  small nuclear ribonucleoprotein G isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) lacks an alternate exon in the 5' end compared to variant 1. The resulting isoform (f) is shorter at the N-terminus compared to isoform a.
      Source sequence(s)
      AC079338, AI742299, AV682126, CD109295
      Conserved Domains (1) summary
      cd01719
      Location:256
      Sm_G; Sm protein G
    7. NM_003096.3NP_003087.1  small nuclear ribonucleoprotein G isoform a

      See identical proteins and their annotated locations for NP_003087.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the highly conserved isoform (a).
      Source sequence(s)
      AC079338, AI742299, AV682126, BC106055, DW428820
      Consensus CDS
      CCDS1903.1
      UniProtKB/Swiss-Prot
      P62308
      Related
      ENSP00000272348.2, OTTHUMP00000160076, ENST00000272348.6, OTTHUMT00000251871
      Conserved Domains (1) summary
      cd01719
      Location:574
      Sm_G; Sm protein G

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

      Range
      70281362..70293771 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017004774.1XP_016860263.1  small nuclear ribonucleoprotein G isoform X1

      UniProtKB/TrEMBL
      C9JVQ0
      Conserved Domains (1) summary
      cd01719
      Location:560
      Sm_G; Sm protein G
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