Trpv4 transient receptor potential cation channel, subfamily V, member 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Trpv4provided by RGD
Official Full Name: transient receptor potential cation channel, subfamily V, member 4provided by RGD
Primary source: RGD:69337
See related: Ensembl:ENSRNOG00000001195 AllianceGenome:RGD:69337
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Vroac; Otrpc4
Summary: Enables calcium channel activity; cytoskeletal protein binding activity; and protein kinase C binding activity. Involved in several processes, including calcium ion transport; cytoskeleton organization; and positive regulation of microtubule depolymerization. Located in several cellular components, including focal adhesion; lamellipodium; and ruffle membrane. Colocalizes with cytoplasmic microtubule. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2C; motor neuron disease (multiple); osteochondrodysplasia (multiple); and osteonecrosis. Orthologous to human TRPV4 (transient receptor potential cation channel subfamily V member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 138.5), Lung (RPKM 14.0) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q16

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (47599161..47638143)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (41938533..41977517)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (47698915..47737902)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fatty acid metabolism promotes TRPV4 activity in lung microvascular endothelial cells in pulmonary arterial hypertension.
Title: Fatty acid metabolism promotes TRPV4 activity in lung microvascular endothelial cells in pulmonary arterial hypertension.
TRPV4 blockade alleviates endoplasmic reticulum stress mediated apoptosis in hypoxia-induced cardiomyocyte injury.
Title: TRPV4 blockade alleviates endoplasmic reticulum stress mediated apoptosis in hypoxia-induced cardiomyocyte injury.
PAR2-dependent phosphorylation of TRPV4 at the trigeminal nerve terminals contributes to tongue cancer pain.
Title: PAR2-dependent phosphorylation of TRPV4 at the trigeminal nerve terminals contributes to tongue cancer pain.
Upregulation of hypothalamic TRPV4 via S100a4/AMPKalpha signaling pathway promotes the development of diet-induced obesity.
Title: Upregulation of hypothalamic TRPV4 via S100a4/AMPKα signaling pathway promotes the development of diet-induced obesity.
[Preliminary study of TRPV4 affects chondrocyte degeneration].
Title: [Preliminary study of TRPV4 affects chondrocyte degeneration].
Roles of TRPV4 in Regulating Circulating Angiogenic Cells to Promote Coronary Microvascular Regeneration.
Title: Roles of TRPV4 in Regulating Circulating Angiogenic Cells to Promote Coronary Microvascular Regeneration.
Antagonism of TRPV4 channels partially reduces mechanotransduction in rat skeletal muscle afferents.
Title: Antagonism of TRPV4 channels partially reduces mechanotransduction in rat skeletal muscle afferents.
TRPV4 functional status in cystic cells regulates cystogenesis in autosomal recessive polycystic kidney disease during variations in dietary potassium.
Title: TRPV4 functional status in cystic cells regulates cystogenesis in autosomal recessive polycystic kidney disease during variations in dietary potassium.
TRPV4 activation prevents lipopolysaccharide-induced painful bladder hypersensitivity in rats by regulating immune pathways.
Title: TRPV4 activation prevents lipopolysaccharide-induced painful bladder hypersensitivity in rats by regulating immune pathways.
Transient receptor potential vanilloid type 4 (TRPV4) in urinary bladder structure and function.
Title: Transient receptor potential vanilloid type 4 (TRPV4) in urinary bladder structure and function.

Submit: New GeneRIF Correction See all GeneRIFs (126)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Trpv4 (e-PCR), detects polymorphism
- UniSTS:531257

D12Got95 (e-PCR)
- UniSTS:112191

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables SH2 domain binding	ISO Inferred from Sequence Orthology more info
enables actin binding	IDA Inferred from Direct Assay more info	PubMed
enables actin filament binding	IDA Inferred from Direct Assay more info	PubMed
enables alpha-tubulin binding	IDA Inferred from Direct Assay more info	PubMed
enables beta-tubulin binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables calcium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables calcium channel activity	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables monoatomic cation channel activity	IDA Inferred from Direct Assay more info	PubMed
enables monoatomic cation channel activity	ISO Inferred from Sequence Orthology more info
enables monoatomic cation channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables osmosensor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase C binding	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables stretch-activated, monoatomic cation-selective, calcium channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ATP export	ISO Inferred from Sequence Orthology more info
involved_in ATP transport	ISO Inferred from Sequence Orthology more info
involved_in actin cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament organization	IDA Inferred from Direct Assay more info	PubMed
involved_in actin filament organization	ISO Inferred from Sequence Orthology more info
involved_in blood vessel endothelial cell delamination	ISO Inferred from Sequence Orthology more info
involved_in calcium ion import	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium ion import	ISO Inferred from Sequence Orthology more info
involved_in calcium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium ion import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in calcium ion import into cytosol	ISO Inferred from Sequence Orthology more info
involved_in calcium ion import into cytosol	ISS Inferred from Sequence or Structural Similarity more info
involved_in calcium ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in cartilage development involved in endochondral bone morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cartilage homeostasis	ISO Inferred from Sequence Orthology more info
involved_in cell-cell junction assembly	ISO Inferred from Sequence Orthology more info
involved_in cell-cell junction assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular hypotonic response	ISO Inferred from Sequence Orthology more info
involved_in cellular hypotonic salinity response	ISO Inferred from Sequence Orthology more info
involved_in cellular response to heat	ISO Inferred from Sequence Orthology more info
involved_in cellular response to heat	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to osmotic stress	ISO Inferred from Sequence Orthology more info
involved_in cellular response to osmotic stress	ISS Inferred from Sequence or Structural Similarity more info
involved_in cortical microtubule organization	IDA Inferred from Direct Assay more info	PubMed
involved_in diet induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in energy homeostasis	ISO Inferred from Sequence Orthology more info
involved_in glucose homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hyperosmotic salinity response	ISO Inferred from Sequence Orthology more info
involved_in hypotonic response	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular calcium ion homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in microtubule polymerization	IDA Inferred from Direct Assay more info	PubMed
involved_in multicellular organismal-level water homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multicellular organismal-level water homeostasis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of brown fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell volume	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron projection development	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in osmosensory signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within osmosensory signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in osmosensory signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chemokine (C-C motif) ligand 5 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chemokine (C-X-C motif) ligand 1 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intracellular protein transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage inflammatory protein 1 alpha production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of membrane hyperpolarization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of microtubule depolymerization	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of monocyte chemotactic protein-1 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of prostaglandin secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of striated muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of vascular permeability	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of vascular permeability	ISO Inferred from Sequence Orthology more info
involved_in regulation of aerobic respiration	ISO Inferred from Sequence Orthology more info
NOT involved_in regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in regulation of heart rate	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in regulation of p38MAPK cascade	ISO Inferred from Sequence Orthology more info
NOT involved_in regulation of response to osmotic stress	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of response to osmotic stress	ISO Inferred from Sequence Orthology more info
involved_in relaxation of vascular associated smooth muscle	ISO Inferred from Sequence Orthology more info
NOT involved_in response to fatty acid	ISO Inferred from Sequence Orthology more info
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to insulin	ISO Inferred from Sequence Orthology more info
NOT involved_in response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to osmotic stress	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vasopressin secretion	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in adherens junction	ISO Inferred from Sequence Orthology more info
located_in adherens junction	ISS Inferred from Sequence or Structural Similarity more info
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
is_active_in cilium	IBA Inferred from Biological aspect of Ancestor more info
located_in cilium	ISO Inferred from Sequence Orthology more info
located_in cortical actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in filopodium	IDA Inferred from Direct Assay more info	PubMed
located_in focal adhesion	IDA Inferred from Direct Assay more info	PubMed
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in ruffle membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: transient receptor potential cation channel subfamily V member 4

Names: VR-OAC; osm-9-like TRP channel 4; osmosensitive transient receptor potential channel 4; transient receptor potential cation channel subf V memb 4; transient receptor potential cation channel, subfamily 5, member 4; vanilloid receptor-related osmotically activated channel (Vroac); vanilloid receptor-related osmotically-activated channel

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_023970.1 → NP_076460.1 transient receptor potential cation channel subfamily V member 4

See identical proteins and their annotated locations for NP_076460.1

Status: PROVISIONAL

Source sequence(s)

AF263521

UniProtKB/Swiss-Prot

Q9ERZ8

UniProtKB/TrEMBL

A0A8I6ANU0, A6J1Z3

Related

ENSRNOP00000001586.1, ENSRNOT00000001586.3

Conserved Domains (2) summary

sd00045
Location:237 → 268

ANK; ANK repeat [structural motif]

cd22195
Location:103 → 834

TRPV4; Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 4

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

47599161..47638143

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006249466.3 → XP_006249528.1 transient receptor potential cation channel subfamily V member 4 isoform X1

See identical proteins and their annotated locations for XP_006249528.1

UniProtKB/Swiss-Prot

Q9ERZ8

UniProtKB/TrEMBL

A0A8I6ANU0, A6J1Z3

Conserved Domains (2) summary

sd00045
Location:237 → 268

ANK; ANK repeat [structural motif]

cd22195
Location:103 → 834

TRPV4; Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 4