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    Asb1 ankyrin repeat and SOCS box-containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 65247, updated on 5-Aug-2018

    Summary

    Official Symbol
    Asb1provided by MGI
    Official Full Name
    ankyrin repeat and SOCS box-containing 1provided by MGI
    Primary source
    MGI:MGI:1929735
    See related
    Ensembl:ENSMUSG00000026311 Vega:OTTMUSG00000048498
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI426616; AI851378; mKIAA1146; 1700029O08Rik; 1700054C17Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 17.6), liver E14 (RPKM 5.4) and 23 other tissues See more
    Orthologs

    Genomic context

    See Asb1 in Genome Data Viewer
    Location:
    1 D; 1 46.19 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (91539455..91559590)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (93437142..93456167)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene nucleolar complex associated 3 homolog pseudogene Neighboring gene TRAF3 interacting protein 1 Neighboring gene predicted gene 28380 Neighboring gene twist basic helix-loop-helix transcription factor 2 Neighboring gene predicted gene, 46117

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    male genitalia development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ankyrin repeat and SOCS box protein 1
    Names
    ASB-1
    ankyrin repeat and SOCS box-containing protein 1
    ankyrin repeat-containing SOCS box protein 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039126.2NP_001034215.1  ankyrin repeat and SOCS box protein 1 isoform a

      See identical proteins and their annotated locations for NP_001034215.1

      Status: VALIDATED

      Source sequence(s)
      AC109199, AK153774, BY231875
      Consensus CDS
      CCDS35665.1
      UniProtKB/Swiss-Prot
      Q9WV74
      UniProtKB/TrEMBL
      Q3U5A0
      Related
      ENSMUSP00000084054.5, OTTMUSP00000067671, ENSMUST00000086843.10, OTTMUST00000124308
      Conserved Domains (5) summary
      cd00204
      Location:80213
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd03720
      Location:295336
      SOCS_ASB1; SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The ...
      pfam12796
      Location:83174
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:4099
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:80109
      ANK; ANK repeat [structural motif]
    2. NM_023046.4NP_075533.3  ankyrin repeat and SOCS box protein 1 isoform b

      See identical proteins and their annotated locations for NP_075533.3

      Status: VALIDATED

      Source sequence(s)
      AC109199, AK153774, BU938650
      Consensus CDS
      CCDS35666.1
      UniProtKB/TrEMBL
      G3X9J5, Q3U5A0
      Related
      ENSMUSP00000140731.1, OTTMUSP00000067676, ENSMUST00000188879.1, OTTMUST00000124315
      Conserved Domains (5) summary
      cd00204
      Location:72205
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd03720
      Location:287328
      SOCS_ASB1; SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The ...
      pfam12796
      Location:75166
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:3291
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:72101
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      91539455..91559590
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529790.3XP_006529853.1  ankyrin repeat and SOCS box protein 1 isoform X2

      Related
      ENSMUSP00000140281.1, OTTMUSP00000067673, ENSMUST00000190484.6, OTTMUST00000124312
      Conserved Domains (4) summary
      cd00204
      Location:40166
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd03720
      Location:194235
      SOCS_ASB1; SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The ...
      pfam12796
      Location:42166
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:3972
      ANK; ANK repeat [structural motif]
    2. XM_006529789.1XP_006529852.1  ankyrin repeat and SOCS box protein 1 isoform X1

      Conserved Domains (5) summary
      cd00204
      Location:76209
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd03720
      Location:291332
      SOCS_ASB1; SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The ...
      pfam12796
      Location:79170
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:3695
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:76105
      ANK; ANK repeat [structural motif]
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