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    NADK NAD kinase [ Homo sapiens (human) ]

    Gene ID: 65220, updated on 2-Oct-2018

    Summary

    Official Symbol
    NADKprovided by HGNC
    Official Full Name
    NAD kinaseprovided by HGNC
    Primary source
    HGNC:HGNC:29831
    See related
    Ensembl:ENSG00000008130 MIM:611616; Vega:OTTHUMG00000000942
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    dJ283E3.1
    Summary
    NADK catalyzes the transfer of a phosphate group from ATP to NAD to generate NADP, which in its reduced form acts as an electron donor for biosynthetic reactions (Lerner et al., 2001 [PubMed 11594753]).[supplied by OMIM, Mar 2008]
    Expression
    Ubiquitous expression in bone marrow (RPKM 24.4), spleen (RPKM 23.0) and 25 other tissues See more
    Orthologs

    Genomic context

    See NADK in Genome Data Viewer
    Location:
    1p36.33
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (1751232..1780509, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (1682671..1711508, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene cyclin dependent kinase 11A Neighboring gene ribosomal protein S7 pseudogene Neighboring gene solute carrier family 35 member E2A Neighboring gene uncharacterized LOC112268218 Neighboring gene G protein subunit beta 1 Neighboring gene collagen alpha-2(VIII) chain Neighboring gene calmodulin like 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC1900, FLJ13052, FLJ37724, FLJ54695, FLJ77769, FLJ78247, FLJ78307, DKFZp686L22239

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    NAD+ kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NAD+ kinase activity TAS
    Traceable Author Statement
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    ATP metabolic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    NAD metabolic process TAS
    Traceable Author Statement
    more info
     
    NADP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    phosphorylation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    positive regulation of insulin secretion involved in cellular response to glucose stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytosol TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    NAD kinase
    Names
    poly(P)/ATP NAD kinase
    NP_001185922.1
    NP_001185923.1
    NP_001185924.1
    NP_001340570.1
    NP_001340571.1
    NP_075394.3
    XP_006710902.1
    XP_011540308.1
    XP_011540309.1
    XP_011540310.1
    XP_011540311.1
    XP_016857632.1
    XP_016857633.1
    XP_016857634.1
    XP_016857635.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001198993.1NP_001185922.1  NAD kinase isoform 1

      See identical proteins and their annotated locations for NP_001185922.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 5' UTR compared to variant 1. Variants 1, 2 and 5 encode the same isoform (1).
      Source sequence(s)
      AL031282, BC001709, BC024219, BM842058, CN349189
      Consensus CDS
      CCDS30565.1
      UniProtKB/Swiss-Prot
      O95544
      UniProtKB/TrEMBL
      A0A024R058, Q6PJ22
      Related
      ENSP00000344340.3, OTTHUMP00000001110, ENST00000341991.7, OTTHUMT00000002768
      Conserved Domains (1) summary
      cl28462
      Location:96433
      pnk; inorganic polyphosphate/ATP-NAD kinase; Provisional
    2. NM_001198994.1NP_001185923.1  NAD kinase isoform 2

      See identical proteins and their annotated locations for NP_001185923.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and CDS compared to variant 1. The resulting isoform (2) has two additional internal segments, as compared to isoform 1.
      Source sequence(s)
      AF250320, AL031282, BC001709, BM842058
      Consensus CDS
      CCDS55562.1
      UniProtKB/Swiss-Prot
      O95544
      Related
      ENSP00000367890.1, OTTHUMP00000001109, ENST00000378625.5, OTTHUMT00000002767
      Conserved Domains (1) summary
      cl01255
      Location:202578
      DAGK_cat; Diacylglycerol kinase catalytic domain
    3. NM_001198995.1NP_001185924.1  NAD kinase isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks three exons from the 5' end and has an alternate 5' exon compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus, as compared to isoform 1.
      Source sequence(s)
      AK296722, AL031282, BC001709, BM842058
      Consensus CDS
      CCDS55561.1
      UniProtKB/Swiss-Prot
      O95544
      UniProtKB/TrEMBL
      A0A0A0MR98
      Related
      ENSP00000339727.5, OTTHUMP00000039051, ENST00000342348.9, OTTHUMT00000100202
      Conserved Domains (1) summary
      cl01255
      Location:66401
      DAGK_cat; Diacylglycerol kinase catalytic domain
    4. NM_001353641.1NP_001340570.1  NAD kinase isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 5 encode the same isoform (1).
      Source sequence(s)
      AL031282
      Consensus CDS
      CCDS30565.1
      Conserved Domains (1) summary
      cl28462
      Location:96433
      pnk; inorganic polyphosphate/ATP-NAD kinase; Provisional
    5. NM_001353642.1NP_001340571.1  NAD kinase isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) uses and alternate splice site which results in the use of an alternate start codon compared to variant 1. The encoded isoform (4) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AL031282
      Conserved Domains (1) summary
      cl28462
      Location:9346
      pnk; inorganic polyphosphate/ATP-NAD kinase; Provisional
    6. NM_023018.4NP_075394.3  NAD kinase isoform 1

      See identical proteins and their annotated locations for NP_075394.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes variant 1 isoform (1). Variants 1, 2 and 5 encode the same isoform (1).
      Source sequence(s)
      AK023114, AL031282, BC001709, BM842058
      Consensus CDS
      CCDS30565.1
      UniProtKB/Swiss-Prot
      O95544
      UniProtKB/TrEMBL
      A0A024R058
      Related
      ENSP00000341679.5, OTTHUMP00000001111, ENST00000341426.9, OTTHUMT00000002769
      Conserved Domains (1) summary
      cl28462
      Location:96433
      pnk; inorganic polyphosphate/ATP-NAD kinase; Provisional

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

      Range
      1751232..1780509 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006710839.2XP_006710902.1  NAD kinase isoform X5

      Conserved Domains (1) summary
      cl01255
      Location:202537
      DAGK_cat; Diacylglycerol kinase catalytic domain
    2. XM_011542007.2XP_011540309.1  NAD kinase isoform X2

      See identical proteins and their annotated locations for XP_011540309.1

      Conserved Domains (1) summary
      cl01255
      Location:68330
      DAGK_cat; Diacylglycerol kinase catalytic domain
    3. XM_017002143.2XP_016857632.1  NAD kinase isoform X1

    4. XM_011542009.2XP_011540311.1  NAD kinase isoform X2

      See identical proteins and their annotated locations for XP_011540311.1

      Conserved Domains (1) summary
      cl01255
      Location:68330
      DAGK_cat; Diacylglycerol kinase catalytic domain
    5. XM_011542008.1XP_011540310.1  NAD kinase isoform X2

      See identical proteins and their annotated locations for XP_011540310.1

      Conserved Domains (1) summary
      cl01255
      Location:68330
      DAGK_cat; Diacylglycerol kinase catalytic domain
    6. XM_017002146.1XP_016857635.1  NAD kinase isoform X4

    7. XM_011542006.1XP_011540308.1  NAD kinase isoform X2

      See identical proteins and their annotated locations for XP_011540308.1

      Conserved Domains (1) summary
      cl01255
      Location:68330
      DAGK_cat; Diacylglycerol kinase catalytic domain
    8. XM_017002145.2XP_016857634.1  NAD kinase isoform X4

    9. XM_017002144.2XP_016857633.1  NAD kinase isoform X3

    RNA

    1. XR_946747.2 RNA Sequence

    2. XR_001737371.2 RNA Sequence

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