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    ENGASE endo-beta-N-acetylglucosaminidase [ Homo sapiens (human) ]

    Gene ID: 64772, updated on 2-Oct-2018

    Summary

    Official Symbol
    ENGASEprovided by HGNC
    Official Full Name
    endo-beta-N-acetylglucosaminidaseprovided by HGNC
    Primary source
    HGNC:HGNC:24622
    See related
    Ensembl:ENSG00000167280 MIM:611898; Vega:OTTHUMG00000167714
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a cytosolic enzyme which catalyzes the hydrolysis of peptides and proteins with mannose modifications to produce free oligosaccharides. [provided by RefSeq, Feb 2012]
    Expression
    Ubiquitous expression in spleen (RPKM 23.3), duodenum (RPKM 12.9) and 24 other tissues See more
    Orthologs

    Genomic context

    See ENGASE in Genome Data Viewer
    Location:
    17q25.3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (79074812..79088603)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (77067565..77084685)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene C1QTNF1 antisense RNA 1 Neighboring gene calcium activated nucleotidase 1 Neighboring gene C1q and TNF related 1 Neighboring gene RNA binding fox-1 homolog 3 Neighboring gene microRNA 4739

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ21865, DKFZp434P174

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    protein deglycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein folding TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    cytosol TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    cytosolic endo-beta-N-acetylglucosaminidase
    Names
    Di-N-acetylchitobiosyl beta-N-acetylglucosaminidase
    Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase
    NP_001036038.1
    XP_006722080.1
    XP_006722081.1
    XP_006722082.1
    XP_016880450.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042573.2NP_001036038.1  cytosolic endo-beta-N-acetylglucosaminidase

      See identical proteins and their annotated locations for NP_001036038.1

      Status: VALIDATED

      Source sequence(s)
      AC073624, AF512564, AK025518
      Consensus CDS
      CCDS42394.1
      UniProtKB/Swiss-Prot
      Q8NFI3
      Related
      ENSP00000462333.1, OTTHUMP00000236598, ENST00000579016.5, OTTHUMT00000395807
      Conserved Domains (1) summary
      cd06547
      Location:126444
      GH85_ENGase; Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins. The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with the ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

      Range
      79074812..79088603
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006722019.3XP_006722082.1  cytosolic endo-beta-N-acetylglucosaminidase isoform X4

      Conserved Domains (1) summary
      cd06547
      Location:126382
      GH85_ENGase; Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins. The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with the ...
    2. XM_017024961.1XP_016880450.1  cytosolic endo-beta-N-acetylglucosaminidase isoform X1

      Conserved Domains (1) summary
      cd06547
      Location:1314
      GH85_ENGase; Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins. The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with the ...
    3. XM_006722017.3XP_006722080.1  cytosolic endo-beta-N-acetylglucosaminidase isoform X2

      Conserved Domains (1) summary
      cd06547
      Location:3258
      GH85_ENGase; Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins. The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with the ...
    4. XM_006722018.3XP_006722081.1  cytosolic endo-beta-N-acetylglucosaminidase isoform X3

      Conserved Domains (1) summary
      cl10447
      Location:44150
      GH18_chitinase-like; The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have ...

    RNA

    1. XR_001752594.1 RNA Sequence

      Related
      ENST00000300682.14, OTTHUMT00000395808
    2. XR_429920.1 RNA Sequence

    3. XR_934534.1 RNA Sequence

    4. XR_429918.1 RNA Sequence

    5. XR_429919.1 RNA Sequence

    6. XR_934535.1 RNA Sequence

    7. XR_934536.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_022759.1: Suppressed sequence

      Description
      NM_022759.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
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