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    Hand2 heart and neural crest derivatives expressed 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64637, updated on 2-Oct-2018

    Summary

    Official Symbol
    Hand2provided by RGD
    Official Full Name
    heart and neural crest derivatives expressed 2provided by RGD
    Primary source
    RGD:621207
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    acts in complex with Gata4 to activate transcription of cardiac specific genes [RGD, Feb 2006]
    Annotation information
    Annotation category: partial on reference assembly
    Expression
    Biased expression in Heart (RPKM 128.0), Adrenal (RPKM 49.3) and 2 other tissues See more

    Genomic context

    See Hand2 in Genome Data Viewer
    Location:
    16p11
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (36371489..36373551, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 16 NC_005115.3 (36173054..36174762, complement)

    Chromosome 16 - NC_005115.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103693946 Neighboring gene heart- and neural crest derivatives-expressed protein 2-like Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene 60S ribosomal protein L7 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    General gene information

    Markers

    Homology

    • Homologs of the Hand2 gene: The Hand2 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, zebrafish, and frog.

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    AT DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    E-box binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to E-box binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    activating transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription coactivator activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to transcription regulatory region DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    adult heart development ISO
    Inferred from Sequence Orthology
    more info
     
    angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    apoptotic process involved in heart morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    cardiac neural crest cell development involved in outflow tract morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    cardiac neural crest cell migration involved in outflow tract morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    cardiac right ventricle formation ISO
    Inferred from Sequence Orthology
    more info
     
    cartilage morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cell proliferation involved in outflow tract morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to retinoic acid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    coronary artery morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    determination of heart left/right asymmetry ISO
    Inferred from Sequence Orthology
    more info
     
    embryonic digit morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    heart development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    heart development ISO
    Inferred from Sequence Orthology
    more info
     
    heart looping ISO
    Inferred from Sequence Orthology
    more info
     
    heart morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
     
    mesenchymal cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    mesenchyme development ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cardiac muscle cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    neural crest cell development ISO
    Inferred from Sequence Orthology
    more info
     
    odontogenesis of dentin-containing tooth ISO
    Inferred from Sequence Orthology
    more info
     
    peripheral nervous system neuron development ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cardiac muscle hypertrophy ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of nucleic acid-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of p38MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of semaphorin-plexin signaling pathway involved in outflow tract morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter involved in norepinephrine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription regulatory region DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    primary palate development ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of secondary heart field cardioblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of tissue remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    roof of mouth development ISO
    Inferred from Sequence Orthology
    more info
     
    suckling behavior ISO
    Inferred from Sequence Orthology
    more info
     
    sympathetic nervous system development ISO
    Inferred from Sequence Orthology
    more info
     
    thymus development ISO
    Inferred from Sequence Orthology
    more info
     
    tongue development ISO
    Inferred from Sequence Orthology
    more info
     
    visceral serous pericardium development ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    nuclear chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IC
    Inferred by Curator
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    heart- and neural crest derivatives-expressed protein 2
    Names
    dHand protein
    deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2
    heart and neural crest derivatives expressed transcript 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022696.1NP_073187.1  heart- and neural crest derivatives-expressed protein 2

      See identical proteins and their annotated locations for NP_073187.1

      Status: PROVISIONAL

      Source sequence(s)
      Y08138
      UniProtKB/Swiss-Prot
      P61295
      Conserved Domains (1) summary
      pfam00010
      Location:100151
      HLH; Helix-loop-helix DNA-binding domain

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005115.4 Reference Rnor_6.0 Primary Assembly

      Range
      36371489..36373551 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000084.1 Alternate Rn_Celera

      Range
      32856614..32879368 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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