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    FAM110C family with sequence similarity 110 member C [ Homo sapiens (human) ]

    Gene ID: 642273, updated on 5-Aug-2018

    Summary

    Official Symbol
    FAM110Cprovided by HGNC
    Official Full Name
    family with sequence similarity 110 member Cprovided by HGNC
    Primary source
    HGNC:HGNC:33340
    See related
    Ensembl:ENSG00000184731 MIM:611395; Vega:OTTHUMG00000151321
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Broad expression in esophagus (RPKM 9.1), colon (RPKM 5.4) and 20 other tissues See more
    Orthologs

    Genomic context

    See FAM110C in Genome Data Viewer
    Location:
    2p25.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (38814..47077, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (38814..47042, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373324 Neighboring gene SH3 and SYLF domain containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Whole genome association scan for genetic polymorphisms influencing information processing speed.
    NHGRI GWA Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    alpha-tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    alpha-tubulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    positive regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein kinase B signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cell projection assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of cell projection assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cell cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell cortex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule organizing center IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    spindle pole IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077710.2NP_001071178.2  protein FAM110C

      See identical proteins and their annotated locations for NP_001071178.2

      Status: VALIDATED

      Source sequence(s)
      AC097643
      Consensus CDS
      CCDS42645.1
      UniProtKB/Swiss-Prot
      Q1W6H9
      Related
      ENSP00000328347.4, OTTHUMP00000199834, ENST00000327669.4, OTTHUMT00000322220
      Conserved Domains (2) summary
      pfam14160
      Location:194303
      FAM110_C; Centrosome-associated C terminus
      pfam14161
      Location:1449
      FAM110_N; Centrosome-associated N terminus

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

      Range
      38814..47077 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017004691.1XP_016860180.1  protein FAM110C isoform X2

    2. XM_011510372.2XP_011508674.1  protein FAM110C isoform X4

      See identical proteins and their annotated locations for XP_011508674.1

      Conserved Domains (2) summary
      pfam14160
      Location:194303
      FAM110_C; Centrosome-associated C terminus
      pfam14161
      Location:1449
      FAM110_N; Centrosome-associated N terminus
    3. XM_017004689.1XP_016860178.1  protein FAM110C isoform X1

    4. XM_017004690.1XP_016860179.1  protein FAM110C isoform X1

    5. XM_017004692.1XP_016860181.1  protein FAM110C isoform X3

    RNA

    1. XR_001738890.1 RNA Sequence

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