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    Dnajc3 DnaJ heat shock protein family (Hsp40) member C3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 63880, updated on 9-Oct-2018

    Summary

    Official Symbol
    Dnajc3provided by RGD
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member C3provided by RGD
    Primary source
    RGD:708518
    See related
    Ensembl:ENSRNOG00000010352
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    mouse homolog inhibits interferon-induced double-stranded RNA-activated protein kinase (PKR) [RGD, Feb 2006]
    Expression
    Biased expression in Liver (RPKM 1194.3), Kidney (RPKM 477.0) and 9 other tissues See more
    Orthologs

    Genomic context

    See Dnajc3 in Genome Data Viewer
    Location:
    15q24
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (104186918..104226236)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 15 NC_005114.3 (107610329..107649355)

    Chromosome 15 - NC_005114.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102554323 Neighboring gene claudin 10 Neighboring gene protein S100-A10 pseudogene Neighboring gene DAZ interacting zinc finger protein 1 Neighboring gene UDP-glucose glycoprotein glucosyltransferase 2 Neighboring gene heparan sulfate 6-O-sulfotransferase 3 Neighboring gene uncharacterized LOC102546571

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Influenza A, organism-specific biosystem (from KEGG)
      Influenza A, organism-specific biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Influenza A, conserved biosystem (from KEGG)
      Influenza A, conserved biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
      Neutrophil degranulation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    chaperone binding ISO
    Inferred from Sequence Orthology
    more info
     
    misfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    misfolded protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein kinase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase inhibitor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    cellular response to cold ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to cold ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of translation initiation in response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of translation initiation in response to endoplasmic reticulum stress ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein folding in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    proteolysis involved in cellular protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    proteolysis involved in cellular protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
     
    response to unfolded protein IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum lumen IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum lumen ISO
    Inferred from Sequence Orthology
    more info
     
    smooth endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    dnaJ homolog subfamily C member 3
    Names
    DnaJ (Hsp40) homolog, subfamily C, member 3
    interferon-induced, double-stranded RNA-activated protein kinase inhibitor
    protein kinase inhibitor of 58 kDa
    protein kinase inhibitor p58

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022232.1NP_071568.1  dnaJ homolog subfamily C member 3 precursor

      See identical proteins and their annotated locations for NP_071568.1

      Status: PROVISIONAL

      Source sequence(s)
      AB017702
      UniProtKB/Swiss-Prot
      Q9R0T3
      Related
      ENSRNOP00000014182.2, ENSRNOT00000014182.5
      Conserved Domains (5) summary
      COG0484
      Location:392498
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      sd00006
      Location:3765
      TPR; TPR repeat [structural motif]
      pfam00226
      Location:394459
      DnaJ; DnaJ domain
      pfam00515
      Location:107137
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:36100
      TPR_11; TPR repeat

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005114.4 Reference Rnor_6.0 Primary Assembly

      Range
      104186918..104226236
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000083.1 Alternate Rn_Celera

      Range
      94875150..94914827
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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