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    KCNK15 potassium two pore domain channel subfamily K member 15 [ Homo sapiens (human) ]

    Gene ID: 60598, updated on 29-Mar-2018
    Official Symbol
    KCNK15provided by HGNC
    Official Full Name
    potassium two pore domain channel subfamily K member 15provided by HGNC
    Primary source
    HGNC:HGNC:13814
    See related
    Ensembl:ENSG00000124249 MIM:607368; Vega:OTTHUMG00000032544
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KT3.3; TASK5; KCNK11; KCNK14; TASK-5; K2p15.1; dJ781B1.1
    Summary
    This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require other non-pore-forming proteins for activity. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in testis (RPKM 2.5), endometrium (RPKM 1.1) and 14 other tissues See more
    Orthologs
    See KCNK15 in Genome Data Viewer
    Location:
    20q13.12
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 20 NC_000020.11 (44745605..44752313)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (43374488..43380954)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1260 Neighboring gene KCNK15 and WISP2 antisense RNA 1 Neighboring gene WNT1 inducible signaling pathway protein 2 Neighboring gene regulating synaptic membrane exocytosis 4 Neighboring gene piggyBac transposable element derived 4 pseudogene 2 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    NHGRI GWAS Catalog

    Description
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    NHGRI GWA Catalog
    • Cardiac conduction, organism-specific biosystem (from REACTOME)
      Cardiac conduction, organism-specific biosystemThe normal sequence of contraction of atria and ventricles of the heart require activation of groups of cardiac cells. The mechanism must elicit rapid changes in heart rate and respond to changes in ...
    • Muscle contraction, organism-specific biosystem (from REACTOME)
      Muscle contraction, organism-specific biosystemIn this module, the processes by which calcium binding triggers actin - myosin interactions and force generation in smooth and striated muscle tissues are annotated.
    • Phase 4 - resting membrane potential, organism-specific biosystem (from REACTOME)
      Phase 4 - resting membrane potential, organism-specific biosystemPhase 4 describes the membrane potential when a cell is not being stimulated. The normal resting potential in the ventricular myocardium is between -85 to -95 mV. The membrane is most permeable to K+...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • KIAA0237

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    potassium channel activity TAS
    Traceable Author Statement
    more info
     
    potassium ion leak channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    NOT voltage-gated ion channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    cardiac conduction TAS
    Traceable Author Statement
    more info
     
    potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    stabilization of membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    potassium channel subfamily K member 15
    Names
    TWIK-related acid-sensitive K(+) channel 5
    acid-sensitive potassium channel protein TASK-5
    potassium channel, subfamily K, member 14
    potassium channel, two pore domain subfamily K, member 15
    two pore K(+) channel KT3.3
    two pore potassium channel KT3.3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022358.3NP_071753.2  potassium channel subfamily K member 15 precursor

      See identical proteins and their annotated locations for NP_071753.2

      Status: REVIEWED

      Source sequence(s)
      AF257081, AF294351, BC082981
      Consensus CDS
      CCDS13337.1
      UniProtKB/Swiss-Prot
      Q9H427
      Related
      ENSP00000361952.3, OTTHUMP00000031072, ENST00000372861.4, OTTHUMT00000079378
      Conserved Domains (1) summary
      pfam07885
      Location:77132
      Ion_trans_2; Ion channel

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p12 Primary Assembly

      Range
      44745605..44752313
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017028003.1XP_016883492.1  potassium channel subfamily K member 15 isoform X1

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