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    ABCE1 ATP binding cassette subfamily E member 1 [ Homo sapiens (human) ]

    Gene ID: 6059, updated on 7-Oct-2018

    Summary

    Official Symbol
    ABCE1provided by HGNC
    Official Full Name
    ATP binding cassette subfamily E member 1provided by HGNC
    Primary source
    HGNC:HGNC:69
    See related
    Ensembl:ENSG00000164163 MIM:601213; Vega:OTTHUMG00000161478
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RLI; OABP; RLI1; ABC38; RNS4I; RNASEL1; RNASELI
    Summary
    The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in appendix (RPKM 18.4), lymph node (RPKM 18.0) and 25 other tissues See more
    Orthologs

    Genomic context

    See ABCE1 in Genome Data Viewer
    Location:
    4q31.21
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 4 NC_000004.12 (145098004..145129524)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (146019156..146050676)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene heat shock protein family D (Hsp60) member 1 pseudogene 5 Neighboring gene anaphase promoting complex subunit 10 Neighboring gene RNA, 7SK small nuclear pseudogene 235 Neighboring gene OTU deubiquitinase 4 Neighboring gene uncharacterized LOC105377465

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag The nucleocapsid (NC) domain of Gag is critical for interaction with endogenous ABCE1 in primate cells; basic residues in NC are critical for the Gag-ABCE1 interaction, while the cysteine and histidine residues in the zinc fingers are dispensable PubMed
    gag ABCE1, DDX6, and AGO2 proteins are associated with HIV-1 Gag in the intracellular high-molecular-weight assembly intermediates PubMed
    gag ABCE1 co-localizes with Gag clusters present at the plasma membrane PubMed
    gag Expression of TULA proteins reduces the production of HIV-1 particles and modulates Gag processing. ABCE1 recruits TULA to Gag PubMed
    gag HIV-1 GagZip chimeric proteins, in which NC was replaced with a heterologous leucine zipper, form ABCE1-containing intermediates, suggesting exposure of an ABCE1-binding domain located elsewhere in Gag, outside NC PubMed
    gag Gag production is significantly increased by fusing HIV-1-infected CD4- and CXCR4-expressing rat fibroblasts with uninfected human T-, B-, and macrophage cell lines. This process is regulated by HP68 and MHC class II transactivator (CIITA) PubMed
    gag Cells expressing a protease-deficient HIV-1 molecular clone demonstrate a prolonged association of Gag and ABCE1 PubMed
    gag HP68 associates post-translationally with HIV-1 Gag and Vif, an interaction that requires the Nucleocapsid domain of Gag and that is essential for assembly of immature HIV-1 capsids PubMed
    Vif vif HuHP68 is essential for HIV-1 capsid assembly and associates with HIV-1 Vif in the form of an HuHP68 complex with HIV-1 Gag PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ATPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    endoribonuclease inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    iron ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ribosomal small subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    negative regulation of endoribonuclease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of type I interferon-mediated signaling pathway TAS
    Traceable Author Statement
    more info
     
    ribosomal subunit export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    translational termination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    viral process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    membrane HDA PubMed 
    mitochondrial matrix TAS
    Traceable Author Statement
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ATP-binding cassette sub-family E member 1
    Names
    2'-5'-oligoadenylate-binding protein
    ATP-binding cassette, sub-family E (OABP), member 1
    RNase L inhibitor 1
    huHP68
    ribonuclease 4 inhibitor
    ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) inhibitor

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047075.1 RefSeqGene

      Range
      5001..36521
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001040876.1NP_001035809.1  ATP-binding cassette sub-family E member 1

      See identical proteins and their annotated locations for NP_001035809.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC096757, BC016283, DA218189
      Consensus CDS
      CCDS34071.1
      UniProtKB/Swiss-Prot
      P61221
      Conserved Domains (1) summary
      COG1245
      Location:4597
      Rli1; Translation initiation factor RLI1, contains Fe-S and AAA+ ATPase domains [Translation, ribosomal structure and biogenesis]
    2. NM_002940.2NP_002931.2  ATP-binding cassette sub-family E member 1

      See identical proteins and their annotated locations for NP_002931.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC096757, BC016283, DA218189
      Consensus CDS
      CCDS34071.1
      UniProtKB/Swiss-Prot
      P61221
      Related
      ENSP00000296577.4, OTTHUMP00000220305, ENST00000296577.8, OTTHUMT00000365104
      Conserved Domains (1) summary
      COG1245
      Location:4597
      Rli1; Translation initiation factor RLI1, contains Fe-S and AAA+ ATPase domains [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p12 Primary Assembly

      Range
      145098004..145129524
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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