Format

Send to:

Choose Destination
    • Showing Current items.

    AGBL5 ATP/GTP binding protein like 5 [ Homo sapiens (human) ]

    Gene ID: 60509, updated on 8-Jul-2018
    Official Symbol
    AGBL5provided by HGNC
    Official Full Name
    ATP/GTP binding protein like 5provided by HGNC
    Primary source
    HGNC:HGNC:26147
    See related
    Ensembl:ENSG00000084693 MIM:615900; Vega:OTTHUMG00000128406
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CCP5; RP75
    Summary
    This gene encodes a metallocarboxypeptidase involved in protein deglutamylation and a member of the peptidase M14 family of proteins. The encoded protein has been described as a "dual-functional" deglutamylase that can remove glutamate residues from both carboxyl termini and side chains of protein substrates. This deglutamylase activity may be important in antiviral immunity. Mutations in this gene are associated with retinitis pigmentosa. [provided by RefSeq, Jul 2016]
    Expression
    Biased expression in testis (RPKM 145.3), thyroid (RPKM 14.3) and 7 other tissues See more
    Orthologs
    See AGBL5 in Genome Data Viewer
    Location:
    2p23.3
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (27051423..27070622)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (27274291..27293490)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene AGBL5 antisense RNA 1 Neighboring gene transfer RNA-Tyr (GTA) 2-1 Neighboring gene oligosaccharyltransferase complex subunit 4, non-catalytic Neighboring gene elastin microfibril interfacer 1 Neighboring gene ketohexokinase Neighboring gene cell growth regulator with EF-hand domain 1

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Replication interactions

    Interaction Pubs
    Knockdown of ATP/GTP binding protein-like 5 (AGBL5) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ21839

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    metallocarboxypeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    tubulin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    defense response to virus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein branching point deglutamylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein deglutamylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    intercellular bridge IDA
    Inferred from Direct Assay
    more info
     
    microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
     
    midbody IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitotic spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Preferred Names
    cytosolic carboxypeptidase-like protein 5
    Names
    cytosolic carboxypeptidase 5
    NP_001030584.1
    NP_068603.4
    XP_005264534.1
    XP_011531313.1
    XP_011531314.1
    XP_011531315.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_052914.1 RefSeqGene

      Range
      5201..24200
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001035507.2NP_001030584.1  cytosolic carboxypeptidase-like protein 5 isoform 3

      See identical proteins and their annotated locations for NP_001030584.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks several exons and its 3' terminal exon extends past a splice site that is used in variant 1, resulting in a novel 3' coding region and 3' UTR compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      BC018584, DA901318
      Consensus CDS
      CCDS42665.1
      UniProtKB/Swiss-Prot
      Q8NDL9
      Related
      ENSP00000323681.8, OTTHUMP00000194458, ENST00000323064.12, OTTHUMT00000309034
      Conserved Domains (1) summary
      cd06236
      Location:176568
      M14_AGBL5_like; Peptidase M14-like domain of ATP/GTP binding protein (AGBL)-5 and related proteins
    2. NM_021831.5NP_068603.4  cytosolic carboxypeptidase-like protein 5 isoform 1

      See identical proteins and their annotated locations for NP_068603.4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AL833844, BC007415, DA901318
      Consensus CDS
      CCDS1732.3
      UniProtKB/Swiss-Prot
      Q8NDL9
      Related
      ENSP00000353249.4, OTTHUMP00000192904, ENST00000360131.4, OTTHUMT00000309033
      Conserved Domains (1) summary
      cd06236
      Location:176568
      M14_AGBL5_like; Peptidase M14-like domain of ATP/GTP binding protein (AGBL)-5 and related proteins

    RNA

    1. NR_104246.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) has an additional exon in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL833844, BC007415, DA901318
      Related
      ENST00000487078.5, OTTHUMT00000250186
    2. NR_138023.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) contains alternate exons in the 5' and 3' regions compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC013403, AC013472, BC007415

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

      Range
      27051423..27070622
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011533011.3XP_011531313.1  cytosolic carboxypeptidase-like protein 5 isoform X1

      See identical proteins and their annotated locations for XP_011531313.1

      UniProtKB/Swiss-Prot
      Q8NDL9
      Conserved Domains (1) summary
      cd06236
      Location:176568
      M14_AGBL5_like; Peptidase M14-like domain of ATP/GTP binding protein (AGBL)-5 and related proteins
    2. XM_005264477.3XP_005264534.1  cytosolic carboxypeptidase-like protein 5 isoform X2

      Conserved Domains (1) summary
      cd06236
      Location:176568
      M14_AGBL5_like; Peptidase M14-like domain of ATP/GTP binding protein (AGBL)-5 and related proteins
    3. XM_011533013.2XP_011531315.1  cytosolic carboxypeptidase-like protein 5 isoform X1

      See identical proteins and their annotated locations for XP_011531315.1

      UniProtKB/Swiss-Prot
      Q8NDL9
      Conserved Domains (1) summary
      cd06236
      Location:176568
      M14_AGBL5_like; Peptidase M14-like domain of ATP/GTP binding protein (AGBL)-5 and related proteins
    4. XM_011533012.2XP_011531314.1  cytosolic carboxypeptidase-like protein 5 isoform X1

      See identical proteins and their annotated locations for XP_011531314.1

      UniProtKB/Swiss-Prot
      Q8NDL9
      Conserved Domains (1) summary
      cd06236
      Location:176568
      M14_AGBL5_like; Peptidase M14-like domain of ATP/GTP binding protein (AGBL)-5 and related proteins
    Support Center