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    TRMT11 tRNA methyltransferase 11 homolog [ Homo sapiens (human) ]

    Gene ID: 60487, updated on 5-Aug-2018

    Summary

    Official Symbol
    TRMT11provided by HGNC
    Official Full Name
    tRNA methyltransferase 11 homologprovided by HGNC
    Primary source
    HGNC:HGNC:21080
    See related
    Ensembl:ENSG00000066651 Vega:OTTHUMG00000015515
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TRM11; MDS024; C6orf75; TRMT11-1
    Expression
    Ubiquitous expression in endometrium (RPKM 2.2), duodenum (RPKM 1.9) and 25 other tissues See more
    Orthologs

    Genomic context

    See TRMT11 in Genome Data Viewer
    Location:
    6q22.32
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 6 NC_000006.12 (125986430..126079719)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (126307576..126360422)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene NCOA7-HINT3 intergenic CAGE-defined high expression enhancer Neighboring gene histidine triad nucleotide binding protein 3 Neighboring gene RNA, 5S ribosomal pseudogene 216 Neighboring gene uncharacterized LOC101928096 Neighboring gene protein phosphatase 1 regulatory inhibitor subunit 14B pseudogene 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.
    NHGRI GWA Catalog

    Pathways from BioSystems

    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • tRNA modification in the nucleus and cytosol, organism-specific biosystem (from REACTOME)
      tRNA modification in the nucleus and cytosol, organism-specific biosystemAt least 92 distinct tRNA nucleotide base modifications have been found. The modifications are made post-transcriptionally by a large group of disparate enzymes located in the nucleus, cytosol, and m...
    • tRNA processing, organism-specific biosystem (from REACTOME)
      tRNA processing, organism-specific biosystemGenes encoding transfer RNAs (tRNAs) are transcribed by RNA polymerase III in the nucleus and by mitochondrial RNA polymerase in the mitochondrion.In the nucleus transcription reactions produce precu...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    tRNA (guanine-N2-)-methyltransferase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    tRNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    tRNA methylation IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    tRNA (guanine(10)-N2)-methyltransferase homolog
    Names
    tRNA guanosine-2'-O-methyltransferase TRM11 homolog
    NP_001026882.2
    NP_001337509.1
    NP_001337510.1
    NP_001337511.1
    NP_001337512.1
    NP_001337513.1
    NP_001337514.1
    NP_001337515.1
    NP_001337516.1
    NP_001337517.1
    NP_001337518.1
    NP_001337519.1
    NP_001337520.1
    NP_001337521.1
    NP_001337522.1
    NP_001337523.1
    NP_001337524.1
    NP_001337525.1
    NP_001337526.1
    XP_016866657.1
    XP_024302284.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001031712.2NP_001026882.2  tRNA (guanine(10)-N2)-methyltransferase homolog isoform a

      See identical proteins and their annotated locations for NP_001026882.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AF532977, BC056878
      Consensus CDS
      CCDS35496.1
      UniProtKB/Swiss-Prot
      Q7Z4G4
      Related
      ENSP00000333934.5, ENST00000334379.10
      Conserved Domains (2) summary
      COG1041
      Location:9416
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]
      cl17173
      Location:190321
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    2. NM_001350580.1NP_001337509.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform b

      Status: VALIDATED

      Source sequence(s)
      AL035689
      Conserved Domains (1) summary
      cl28094
      Location:9404
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]
    3. NM_001350581.1NP_001337510.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3), as well as variants 4-6, encodes isoform c.
      Source sequence(s)
      AL035689
      Conserved Domains (1) summary
      cl28094
      Location:7353
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]
    4. NM_001350582.1NP_001337511.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4), as well as variants 3, 5, and 6, encodes isoform c.
      Source sequence(s)
      AL035689
      Conserved Domains (1) summary
      cl28094
      Location:7353
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]
    5. NM_001350583.1NP_001337512.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5), as well as variants 3, 4, and 6, encodes isoform c.
      Source sequence(s)
      AL035689
      Conserved Domains (1) summary
      cl28094
      Location:7353
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]
    6. NM_001350584.1NP_001337513.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6), as well as variants 3-5, encodes isoform c.
      Source sequence(s)
      AL035689
      Conserved Domains (1) summary
      cl28094
      Location:7353
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]
    7. NM_001350585.1NP_001337514.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform d

      Status: VALIDATED

      Source sequence(s)
      AL035689
      Conserved Domains (1) summary
      cl28094
      Location:1218
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]
    8. NM_001350586.1NP_001337515.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8), as well as variants 9-19, encodes isoform e.
      Source sequence(s)
      AL035689
      Conserved Domains (1) summary
      cl28094
      Location:35183
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]
    9. NM_001350587.1NP_001337516.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9), as well as variants 8 and 10-19, encodes isoform e.
      Source sequence(s)
      AL035689
      Conserved Domains (1) summary
      cl28094
      Location:35183
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]
    10. NM_001350588.1NP_001337517.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10), as well as variants 8, 9, and 11-19, encodes isoform e.
      Source sequence(s)
      AL035689
      Conserved Domains (1) summary
      cl28094
      Location:35183
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]
    11. NM_001350589.1NP_001337518.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11), as well as variants 8-10 and 12-19, encodes isoform e.
      Source sequence(s)
      AL035689
      Conserved Domains (1) summary
      cl28094
      Location:35183
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]
    12. NM_001350590.1NP_001337519.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (12), as well as variants 8-11 and 13-19, encodes isoform e.
      Source sequence(s)
      AL035689
      Conserved Domains (1) summary
      cl28094
      Location:35183
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]
    13. NM_001350591.1NP_001337520.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (13), as well as variants 8-12 and 14-19, encodes isoform e.
      Source sequence(s)
      AL035689
      Conserved Domains (1) summary
      cl28094
      Location:35183
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]
    14. NM_001350592.1NP_001337521.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (14), as well as variants 8-13 and 15-19, encodes isoform e.
      Source sequence(s)
      AL035689
      Conserved Domains (1) summary
      cl28094
      Location:35183
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]
    15. NM_001350593.1NP_001337522.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (15), as well as variants 8-14 and 16-19, encodes isoform e.
      Source sequence(s)
      AL035689
      Conserved Domains (1) summary
      cl28094
      Location:35183
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]
    16. NM_001350594.1NP_001337523.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (16), as well as variants 8-15 and 17-19, encodes isoform e.
      Source sequence(s)
      AL035689
      Conserved Domains (1) summary
      cl28094
      Location:35183
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]
    17. NM_001350595.1NP_001337524.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (17), as well as variants 8-16, 18, and 19, encodes isoform e.
      Source sequence(s)
      AL035689
      Conserved Domains (1) summary
      cl28094
      Location:35183
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]
    18. NM_001350596.1NP_001337525.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (18), as well as variants 8-17 and 19, encodes isoform e.
      Source sequence(s)
      AL035689
      Conserved Domains (1) summary
      cl28094
      Location:35183
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]
    19. NM_001350597.1NP_001337526.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (19), as well as variants 8-18, encodes isoform e.
      Source sequence(s)
      AL035689
      Conserved Domains (1) summary
      cl28094
      Location:35183
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]

    RNA

    1. NR_146795.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL035689
      Related
      ENST00000479748.5
    2. NR_146796.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL035689
    3. NR_146797.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL035689, AL391115
    4. NR_146798.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL035689
    5. NR_146799.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL035689, AL391115
    6. NR_146800.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL035689
    7. NR_146801.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL035689
    8. NR_146802.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL035689
    9. NR_146803.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL035689, AL391115
    10. NR_146804.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL035689, AL391115

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p12 Primary Assembly

      Range
      125986430..126079719
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017011168.1XP_016866657.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform X1

      Conserved Domains (1) summary
      cl28094
      Location:1218
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]
    2. XM_024446516.1XP_024302284.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform X2

      Conserved Domains (1) summary
      cl28094
      Location:35183
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]

    RNA

    1. XR_002956294.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_021820.1: Suppressed sequence

      Description
      NM_021820.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate; both the transcript and the protein have no support.
    Support Center