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    Nek7 NIMA (never in mitosis gene a)-related expressed kinase 7 [ Mus musculus (house mouse) ]

    Gene ID: 59125, updated on 9-Oct-2018

    Summary

    Official Symbol
    Nek7provided by MGI
    Official Full Name
    NIMA (never in mitosis gene a)-related expressed kinase 7provided by MGI
    Primary source
    MGI:MGI:1890645
    See related
    Ensembl:ENSMUSG00000026393 Vega:OTTMUSG00000049434
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AU020186; 2810460C19Rik
    Expression
    Ubiquitous expression in bladder adult (RPKM 17.1), heart adult (RPKM 10.0) and 26 other tissues See more
    Orthologs

    Genomic context

    See Nek7 in Genome Data Viewer
    Location:
    1 E4; 1 60.82 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (138483837..138619757, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (140381291..140516273, complement)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene ATPase, H+ transporting, lysosomal V1 subunit G3 Neighboring gene predicted gene 28500 Neighboring gene predicted gene 5833 Neighboring gene predicted gene 8790

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (3) 
    • Targeted (3)  1 citation
    • Chemically induced (ENU) (1) 

    Pathways from BioSystems

    • NOD-like receptor signaling pathway, organism-specific biosystem (from KEGG)
      NOD-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
    • NOD-like receptor signaling pathway, conserved biosystem (from KEGG)
      NOD-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of telomerase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of telomere capping ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of telomere maintenance via telomerase ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein kinase Nek7
    Names
    NIMA-related expressed kinase 7
    NIMA-related kinase 7
    never in mitosis A-related kinase 7
    nimA-related protein kinase 7
    NP_001298077.1
    NP_067618.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001311148.1NP_001298077.1  serine/threonine-protein kinase Nek7 isoform 2

      See identical proteins and their annotated locations for NP_001298077.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two consecutive coding exons compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK035502, AK149308, BE626935, BQ174652, BY170715
      Consensus CDS
      CCDS78695.1
      UniProtKB/Swiss-Prot
      Q9ES74
      UniProtKB/TrEMBL
      Q3TN15
      Related
      ENSMUSP00000027642.3, OTTMUSP00000068195, ENSMUST00000027642.4, OTTMUST00000126021
      Conserved Domains (1) summary
      cl21453
      Location:9199
      PKc_like; Protein Kinases, catalytic domain
    2. NM_021605.4NP_067618.1  serine/threonine-protein kinase Nek7 isoform 1

      See identical proteins and their annotated locations for NP_067618.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK035502, AK149308, BE626935, BQ174652, BY170715
      Consensus CDS
      CCDS15332.1
      UniProtKB/Swiss-Prot
      Q9ES74
      Related
      ENSMUSP00000140903.2, OTTMUSP00000068193, ENSMUST00000186017.6, OTTMUST00000126019
      Conserved Domains (2) summary
      smart00220
      Location:34286
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd08224
      Location:33294
      STKc_Nek6_7; Catalytic domain of the Serine/Threonine Kinases, Never In Mitosis gene A (NIMA)-related kinase 6 and 7

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      138483837..138619757 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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