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    CARD18 caspase recruitment domain family member 18 [ Homo sapiens (human) ]

    Gene ID: 59082, updated on 21-Dec-2019

    Summary

    Official Symbol
    CARD18provided by HGNC
    Official Full Name
    caspase recruitment domain family member 18provided by HGNC
    Primary source
    HGNC:HGNC:28861
    See related
    Ensembl:ENSG00000255501 MIM:605354
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ICEBERG; UNQ5804; pseudo-ICE
    Expression
    Biased expression in skin (RPKM 6.9) and esophagus (RPKM 0.8) See more
    Orthologs

    Genomic context

    See CARD18 in Genome Data Viewer
    Location:
    11q22.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    109.20191205 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (105137714..105139769, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (105008448..105010461, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene caspase recruitment domain family member 17 Neighboring gene caspase 1 pseudogene 3 Neighboring gene caspase 1 pseudogene 1 Neighboring gene uncharacterized LOC105369469 Neighboring gene olfactory receptor family 2 subfamily AL member 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    CARD domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    caspase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    caspase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    cysteine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    inflammatory response NAS
    Non-traceable Author Statement
    more info
    PubMed 
    inhibition of cysteine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of interleukin-1 beta secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of interleukin-1 beta secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    protein-containing complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    caspase recruitment domain-containing protein 18
    Names
    ICEBERG caspase-1 inhibitor
    caspase-1 inhibitor Iceberg

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021571.4NP_067546.1  caspase recruitment domain-containing protein 18

      See identical proteins and their annotated locations for NP_067546.1

      Status: VALIDATED

      Source sequence(s)
      AP003181, AW295205, AY358231
      Consensus CDS
      CCDS53705.1
      UniProtKB/Swiss-Prot
      P57730
      Related
      ENSP00000436691.1, ENST00000530950.2
      Conserved Domains (1) summary
      cd08325
      Location:687
      CARD_CASP1-like; Caspase activation and recruitment domain found in Caspase-1 and related proteins

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

      Range
      105137714..105139769 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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