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    Grk6 G protein-coupled receptor kinase 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 59076, updated on 28-Oct-2018

    Summary

    Official Symbol
    Grk6provided by RGD
    Official Full Name
    G protein-coupled receptor kinase 6provided by RGD
    Primary source
    RGD:61986
    See related
    Ensembl:ENSRNOG00000014615
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gprk6
    Summary
    G-protein coupled receptor kinase that desensitizes beta adrenergic receptors in myometrium [RGD, Feb 2006]
    Expression
    Biased expression in Thymus (RPKM 344.0), Spleen (RPKM 326.2) and 9 other tissues See more
    Orthologs

    Genomic context

    See Grk6 in Genome Data Viewer
    Location:
    17p14
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (9705917..9721921, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 17 NC_005116.3 (11814901..11830762, complement)

    Chromosome 17 - NC_005116.4Genomic Context describing neighboring genes Neighboring gene PDZ and LIM domain 7 Neighboring gene drebrin 1 Neighboring gene proline rich 7 (synaptic) Neighboring gene uncharacterized LOC102550356 Neighboring gene coagulation factor XII

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Calcium Regulation in the Cardiac Cell, organism-specific biosystem (from WikiPathways)
      Calcium Regulation in the Cardiac Cell, organism-specific biosystemCalcium is a common signaling mechanism, as once it enters the cytoplasm it exerts allosteric regulatory affects on many enzymes and proteins. Calcium can act in signal transduction after influx resu...
    • Chemokine signaling pathway, organism-specific biosystem (from KEGG)
      Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
    • Chemokine signaling pathway, conserved biosystem (from KEGG)
      Chemokine signaling pathway, conserved biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
      Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • G alpha (s) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (s) signalling events, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Morphine addiction, organism-specific biosystem (from KEGG)
      Morphine addiction, organism-specific biosystemMorphine is an alkaloid from the plant extracts of opium poppy. Although morphine is highly effective for the treatment of pain, it is also known to be intensely addictive. We now know that the most ...
    • Morphine addiction, conserved biosystem (from KEGG)
      Morphine addiction, conserved biosystemMorphine is an alkaloid from the plant extracts of opium poppy. Although morphine is highly effective for the treatment of pain, it is also known to be intensely addictive. We now know that the most ...
    • Myometrial Relaxation and Contraction Pathways, organism-specific biosystem (from WikiPathways)
      Myometrial Relaxation and Contraction Pathways, organism-specific biosystemThis pathway illustrates signaling networks implicated in uterine muscle contraction at labor and quiescence throughout gestation (pregnancy). The muscle of the uterus, responsible for contractile ac...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemcomputationally inferred pathway (not manually curated)

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    G protein-coupled receptor kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    G protein-coupled receptor kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    beta-adrenergic receptor kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    beta-adrenergic receptor kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    desensitization of G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    desensitization of G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of anion channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    G protein-coupled receptor kinase 6
    Names
    g protein-coupled receptor kinase GRK6
    NP_001106183.1
    NP_001106184.1
    NP_113845.2
    XP_006253715.1
    XP_008769726.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001112712.1NP_001106183.1  G protein-coupled receptor kinase 6 isoform c

      Status: VALIDATED

      Source sequence(s)
      BQ205012, EX488847, X97439
      UniProtKB/TrEMBL
      P97548
      Conserved Domains (3) summary
      smart00220
      Location:186448
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05630
      Location:185469
      STKc_GRK6; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6
      cl02565
      Location:35179
      RGS; Regulator of G protein signaling (RGS) domain superfamily
    2. NM_001112713.1NP_001106184.1  G protein-coupled receptor kinase 6 isoform b

      Status: VALIDATED

      Source sequence(s)
      AF040750, EX488847
      UniProtKB/TrEMBL
      F1LNP2, Q792R1
      Related
      ENSRNOP00000050134.4, ENSRNOT00000047958.4
      Conserved Domains (3) summary
      smart00220
      Location:186448
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05630
      Location:185469
      STKc_GRK6; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6
      cl02565
      Location:35179
      RGS; Regulator of G protein signaling (RGS) domain superfamily
    3. NM_031657.3NP_113845.2  G protein-coupled receptor kinase 6 isoform a

      Status: VALIDATED

      Source sequence(s)
      BQ205012, EX488847, X97440
      UniProtKB/TrEMBL
      A0A0G2K6E5, P97549
      Related
      ENSRNOP00000073781.1, ENSRNOT00000079063.1
      Conserved Domains (3) summary
      smart00220
      Location:186448
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05630
      Location:185469
      STKc_GRK6; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6
      cl02565
      Location:35179
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005116.4 Reference Rnor_6.0 Primary Assembly

      Range
      9705917..9721921 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006253653.3XP_006253715.1  G protein-coupled receptor kinase 6 isoform X1

      Conserved Domains (3) summary
      smart00220
      Location:154416
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05630
      Location:153437
      STKc_GRK6; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6
      cl02565
      Location:3147
      RGS; Regulator of G protein signaling (RGS) domain superfamily
    2. XM_008771504.1XP_008769726.1  G protein-coupled receptor kinase 6 isoform X2

      Conserved Domains (3) summary
      smart00220
      Location:32294
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05630
      Location:31315
      STKc_GRK6; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6
      cl02565
      Location:125
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    Alternate Rn_Celera

    Genomic

    1. AC_000085.1 Alternate Rn_Celera

      Range
      9255527..9271204 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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