Format

Send to:

Choose Destination
    • Showing Current items.

    Elp2 elongator acetyltransferase complex subunit 2 [ Mus musculus (house mouse) ]

    Gene ID: 58523, updated on 12-Aug-2018

    Summary

    Official Symbol
    Elp2provided by MGI
    Official Full Name
    elongator acetyltransferase complex subunit 2provided by MGI
    Primary source
    MGI:MGI:1889642
    See related
    Ensembl:ENSMUSG00000024271
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Epl2; StIP1; Statip1; AU023723
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 45.7), CNS E14 (RPKM 36.0) and 25 other tissues See more
    Orthologs

    Genomic context

    See Elp2 in Genome Data Viewer
    Location:
    18; 18 A2
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 18 NC_000084.6 (24603894..24638830)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (24762462..24797331)

    Chromosome 18 - NC_000084.6Genomic Context describing neighboring genes Neighboring gene regulation of nuclear pre-mRNA domain containing 1A Neighboring gene solute carrier family 39 (metal ion transporter), member 6 Neighboring gene molybdenum cofactor sulfurase Neighboring gene formin homology 2 domain containing 3 Neighboring gene tubulin polyglutamylase complex subunit 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to RNA polymerase II complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    regulation of JAK-STAT cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    tRNA wobble uridine modification IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Elongator holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Elongator holoenzyme complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    transcription elongation factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription elongation factor complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    elongator complex protein 2
    Names
    STAT3-interacting protein 1
    elongation protein 2 homolog
    signal transducer and activator of transcription 3 interacting protein 1
    signal transducer and activator of transcription interacting protein 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360909.1NP_001347838.1  elongator complex protein 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region, compared to variant 1. It encodes isoform 2 which is shorter compared, to isoform 1.
      Source sequence(s)
      AC131713
      Conserved Domains (3) summary
      COG2319
      Location:595783
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:526568
      7WD40; WD40 repeat [structural motif]
      cl25539
      Location:54371
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. NM_021448.2NP_067423.2  elongator complex protein 2 isoform 1

      See identical proteins and their annotated locations for NP_067423.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK034457, AK168370
      Consensus CDS
      CCDS29103.1
      UniProtKB/Swiss-Prot
      Q91WG4
      Related
      ENSMUSP00000025120.6, ENSMUST00000025120.6
      Conserved Domains (4) summary
      COG2319
      Location:94467
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:54415
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:570612
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:559825
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000084.6 Reference GRCm38.p4 C57BL/6J

      Range
      24603894..24638830
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526129.3XP_006526192.1  elongator complex protein 2 isoform X1

      Conserved Domains (3) summary
      COG2319
      Location:595783
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:526568
      7WD40; WD40 repeat [structural motif]
      cl25539
      Location:54371
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. XM_006526130.3XP_006526193.1  elongator complex protein 2 isoform X2

      Conserved Domains (3) summary
      COG2319
      Location:244517
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:260302
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:249515
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Support Center