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    badb BCL2 associated agonist of cell death b [ Danio rerio (zebrafish) ]

    Gene ID: 58100, updated on 14-Feb-2019

    Summary

    Official Symbol
    badbprovided by ZNC
    Official Full Name
    BCL2 associated agonist of cell death bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-000616-1
    See related
    Ensembl:ENSDARG00000054937
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Cyprinidae; Danio
    Also known as
    bad; fa01b12; wu:fa01b12; wu:fa96d04

    Genomic context

    See badb in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (25129520..25135758, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (24858363..24864601, complement)
    103 previous assembly Zv9 (GCF_000002035.4) 7 NC_007118.5 (26296611..26302825, complement)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene zgc:101765 Neighboring gene glycoprotein hormone subunit alpha 2 Neighboring gene membrane anchored junction protein Neighboring gene exocyst complex component 6B Neighboring gene cytochrome P450, family 26, subfamily b, polypeptide 1 Neighboring gene dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive)

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to ionizing radiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cellular response to ionizing radiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    BCL2-antagonist of cell death b
    Names
    proapoptotic BH3-only protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270595.1NP_001257524.1  BCL2-antagonist of cell death b isoform 1

      See identical proteins and their annotated locations for NP_001257524.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
      Source sequence(s)
      AA495398, EH561412, EH592357
      UniProtKB/TrEMBL
      Q4V925
      Related
      ENSDARP00000071687.3, ENSDART00000077219.5
      Conserved Domains (1) summary
      pfam10514
      Location:51135
      Bcl-2_BAD; Pro-apoptotic Bcl-2 protein, BAD
    2. NM_131579.2NP_571654.1  BCL2-antagonist of cell death b isoform 2

      See identical proteins and their annotated locations for NP_571654.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
      Source sequence(s)
      AA495398, EH498043, EH561412
      UniProtKB/TrEMBL
      Q9I9N2
      Related
      ENSDARP00000106381.1, ENSDART00000121943.3
      Conserved Domains (1) summary
      pfam10514
      Location:51134
      Bcl-2_BAD; Pro-apoptotic Bcl-2 protein, BAD

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      25129520..25135758 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005172305.4XP_005172362.1  BCL2-antagonist of cell death b isoform X1

      See identical proteins and their annotated locations for XP_005172362.1

      UniProtKB/TrEMBL
      Q4V925
      Conserved Domains (1) summary
      pfam10514
      Location:51135
      Bcl-2_BAD; Pro-apoptotic Bcl-2 protein, BAD

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394690.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      99754..104047 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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