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    irak3 interleukin-1 receptor-associated kinase 3 [ Danio rerio (zebrafish) ]

    Gene ID: 567444, updated on 10-Oct-2019

    Summary

    Official Symbol
    irak3provided by ZNC
    Official Full Name
    interleukin-1 receptor-associated kinase 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060503-710
    See related
    Ensembl:ENSDARG00000053131
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Cyprinidae; Danio
    Also known as
    si:dkey-150i15.2
    Orthologs

    Genomic context

    See irak3 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (12781784..12791021, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (12783347..12792122, complement)
    103 previous assembly Zv9 (GCF_000002035.4) 4 NC_007115.5 (11846633..11855489, complement)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene deoxyribose-phosphate aldolase (putative) Neighboring gene helicase (DNA) B Neighboring gene beta-2-microglobulin Neighboring gene high mobility group AT-hook 2

    Genomic regions, transcripts, and products

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    MyD88-dependent toll-like receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    embryonic hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    interleukin-1-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of MAP kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of interleukin-12 production IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of toll-like receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of tumor necrosis factor production IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of NF-kappaB transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    interleukin-1 receptor-associated kinase 3

    NCBI Reference Sequences (RefSeq)

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      12781784..12791021 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017355295.2XP_017210784.1  interleukin-1 receptor-associated kinase 3

      UniProtKB/TrEMBL
      B0UYS2
      Related
      ENSDARP00000067130.5, ENSDART00000067131.6
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