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    capn1b calpain 1, (mu/I) large subunit b [ Danio rerio (zebrafish) ]

    Gene ID: 565106, updated on 14-Feb-2019

    Summary

    Official Symbol
    capn1bprovided by ZNC
    Official Full Name
    calpain 1, (mu/I) large subunit bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060503-491
    See related
    Ensembl:ENSDARG00000052748
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Cyprinidae; Danio
    Also known as
    si:dkeyp-101g1.3; si:ch211-203k12.4

    Genomic context

    See capn1b in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (26298026..26327945, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (26277942..26308100, complement)
    103 previous assembly Zv9 (GCF_000002035.4) 22 NC_007133.5 (26889446..26919256, complement)

    Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene SDE2 telomere maintenance homolog (S. pombe) Neighboring gene mitochondrial ribosomal protein S28 Neighboring gene calpain 2, (m/II) large subunit b Neighboring gene uncharacterized LOC103909602

    Genomic regions, transcripts, and products

    Pathways from BioSystems

    • Apoptosis, organism-specific biosystem (from KEGG)
      Apoptosis, organism-specific biosystemApoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled...
    • Apoptosis, conserved biosystem (from KEGG)
      Apoptosis, conserved biosystemApoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled...
    • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...

    General gene information

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    calcium-dependent cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    calcium-dependent cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    calpain 1, large subunit
    NP_001138267.1
    XP_005174088.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001144795.1NP_001138267.1  calpain 1, large subunit

      Status: PROVISIONAL

      Source sequence(s)
      BX649315
      UniProtKB/TrEMBL
      A5PMP1
      Related
      ENSDARP00000095870.3, ENSDART00000105099.4
      Conserved Domains (4) summary
      PTZ00184
      Location:523662
      PTZ00184; calmodulin; Provisional
      pfam00648
      Location:49345
      Peptidase_C2; Calpain family cysteine protease
      pfam01067
      Location:359506
      Calpain_III; Calpain large subunit, domain III
      cl08302
      Location:610663
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007133.7 Reference GRCz11 Primary Assembly

      Range
      26298026..26327945 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005174031.4XP_005174088.1  calpain 1, large subunit isoform X1

      See identical proteins and their annotated locations for XP_005174088.1

      UniProtKB/TrEMBL
      A0A0R4IG81
      Conserved Domains (4) summary
      PTZ00184
      Location:527666
      PTZ00184; calmodulin; Provisional
      pfam00648
      Location:49345
      Peptidase_C2; Calpain family cysteine protease
      pfam01067
      Location:359510
      Calpain_III; Calpain large subunit, domain III
      cl08302
      Location:614667
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395112.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      253517..278394 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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