Format

Send to:

Choose Destination
    • Showing Current items.

    SELENOS selenoprotein S [ Homo sapiens (human) ]

    Gene ID: 55829, updated on 5-Aug-2018

    Summary

    Official Symbol
    SELENOSprovided by HGNC
    Official Full Name
    selenoprotein Sprovided by HGNC
    Primary source
    HGNC:HGNC:30396
    See related
    Ensembl:ENSG00000131871 MIM:607918; Vega:OTTHUMG00000166441
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SELS; VIMP; ADO15; SBBI8; SEPS1; AD-015
    Summary
    This gene encodes a transmembrane protein that is localized in the endoplasmic reticulum (ER). It is involved in the degradation process of misfolded proteins in the ER, and may also have a role in inflammation control. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Two additional phylogenetically conserved stem-loop structures (Stem-loop 1 and Stem-loop 2) in the 3' UTR of this mRNA have been shown to function as modulators of Sec insertion. An alternatively spliced transcript variant, lacking the SECIS element and encoding a non-Sec containing shorter isoform, has been described for this gene (PMID:23614019). [provided by RefSeq, Jul 2017]
    Expression
    Ubiquitous expression in testis (RPKM 27.4), colon (RPKM 26.5) and 25 other tissues See more
    Orthologs

    Genomic context

    See SELENOS in Genome Data Viewer
    Location:
    15q26.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 15 NC_000015.10 (101270909..101277520, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (101811214..101817700, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene chondroitin sulfate synthase 1 Neighboring gene uncharacterized LOC107984727 Neighboring gene uncharacterized LOC100507472 Neighboring gene small nuclear ribonucleoprotein polypeptide A' Neighboring gene proprotein convertase subtilisin/kexin type 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Common variants in left/right asymmetry genes and pathways are associated with relative hand skill.
    NHGRI GWA Catalog

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC2553, MGC104346

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    antioxidant activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    signaling receptor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    ubiquitin-specific protease binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    ER overload response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ER overload response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell redox homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to insulin stimulus TAS
    Traceable Author Statement
    more info
    PubMed 
    cellular response to lipopolysaccharide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endoplasmic reticulum unfolded protein response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    endoplasmic reticulum unfolded protein response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    establishment of protein localization TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of acute inflammatory response to antigenic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of glucose import TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of glycogen biosynthetic process TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of inflammatory response IC
    Inferred by Curator
    more info
    PubMed 
    negative regulation of interleukin-6 production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of macrophage apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of nitric-oxide synthase biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of tumor necrosis factor production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein ubiquitination TAS
    Traceable Author Statement
    more info
     
    regulation of gluconeogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of nitric oxide metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to glucose IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to redox state IDA
    Inferred from Direct Assay
    more info
    PubMed 
    retrograde protein transport, ER to cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    retrograde protein transport, ER to cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin-dependent ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ubiquitin-dependent ERAD pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    Derlin-1 retrotranslocation complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Derlin-1 retrotranslocation complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Derlin-1-VIMP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Derlin-1-VIMP complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasmic microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
     
    endoplasmic reticulum TAS
    Traceable Author Statement
    more info
    PubMed 
    endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    integral component of endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integral component of endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    low-density lipoprotein particle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    very-low-density lipoprotein particle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    selenoprotein S
    Names
    VCP interacting membrane selenoprotein
    VCP-interacting membrane protein
    tanis
    valosin-containing protein-interacting membrane protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_013322.1 RefSeqGene

      Range
      4976..10314
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_018445.5NP_060915.2  selenoprotein S isoform 1

      See identical proteins and their annotated locations for NP_060915.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript, and encodes a selenocysteine-containing longer isoform (1).
      Source sequence(s)
      AK097011, AK225955, BC005840, BG829960
      Consensus CDS
      CCDS53979.1
      UniProtKB/Swiss-Prot
      Q9BQE4
      Related
      ENSP00000433541.1, OTTHUMP00000232905, ENST00000526049.5, OTTHUMT00000389792
      Conserved Domains (1) summary
      pfam06936
      Location:1187
      Selenoprotein_S; Selenoprotein S (SelS)
    2. NM_203472.2NP_982298.2  selenoprotein S isoform 2

      See identical proteins and their annotated locations for NP_982298.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) is alternatively spliced at the 3' end compared to variant 1, and lacks a selenocysteine (Sec) insertion sequence (SECIS) element in its 3' UTR, which is necessary for the recognition of UGA as a Sec codon. This results in translation termination at the UGA codon and a non-Sec containing shorter isoform (2) compared to isoform 1 (PMID:23614019).
      Source sequence(s)
      BC107774, BG829960, DW430970
      UniProtKB/Swiss-Prot
      Q9BQE4
      UniProtKB/TrEMBL
      Q6GYA4
      Related
      ENSP00000381282.3, OTTHUMP00000232899, ENST00000398226.7, OTTHUMT00000389784
      Conserved Domains (1) summary
      pfam06936
      Location:1187
      Selenoprotein_S; Selenoprotein S (SelS)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p12 Primary Assembly

      Range
      101270909..101277520 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center