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    PECR peroxisomal trans-2-enoyl-CoA reductase [ Homo sapiens (human) ]

    Gene ID: 55825, updated on 5-Aug-2018

    Summary

    Official Symbol
    PECRprovided by HGNC
    Official Full Name
    peroxisomal trans-2-enoyl-CoA reductaseprovided by HGNC
    Primary source
    HGNC:HGNC:18281
    See related
    Ensembl:ENSG00000115425 MIM:605843; Vega:OTTHUMG00000154825
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TERP; DCRRP; PVIARL; HPDHASE; SDR29C1; HSA250303
    Expression
    Broad expression in liver (RPKM 14.1), fat (RPKM 7.2) and 15 other tissues See more
    Orthologs

    Genomic context

    See PECR in Genome Data Viewer
    Location:
    2q35
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (216031656..216081843, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (216903111..216946539, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373870 Neighboring gene melanoregulin Neighboring gene transmembrane protein 169 Neighboring gene Sharpr-MPRA regulatory regions 7837 and 8351 Neighboring gene X-ray repair cross complementing 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    NOT 2,4-dienoyl-CoA reductase (NADPH) activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    trans-2-enoyl-CoA reductase (NADPH) activity EXP
    Inferred from Experiment
    more info
    PubMed 
    trans-2-enoyl-CoA reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    trans-2-enoyl-CoA reductase (NADPH) activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    fatty acid alpha-oxidation TAS
    Traceable Author Statement
    more info
     
    fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    oxidation-reduction process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    oxidation-reduction process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phytol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phytol metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein targeting to peroxisome TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    cytosol TAS
    Traceable Author Statement
    more info
     
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    peroxisomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    peroxisomal membrane TAS
    Traceable Author Statement
    more info
     
    peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    peroxisome IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    peroxisomal trans-2-enoyl-CoA reductase
    Names
    2,4-dienoyl-CoA reductase-related protein
    DCR-RP
    pVI-ARL
    putative short chain alcohol dehydrogenase
    short chain dehydrogenase/reductase family 29C member 1
    NP_060911.2
    XP_024308766.1
    XP_024308767.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018441.5NP_060911.2  peroxisomal trans-2-enoyl-CoA reductase

      See identical proteins and their annotated locations for NP_060911.2

      Status: VALIDATED

      Source sequence(s)
      AC010686, AF212234, BU151224
      Consensus CDS
      CCDS33375.1
      UniProtKB/Swiss-Prot
      Q9BY49
      Related
      ENSP00000265322.7, OTTHUMP00000206786, ENST00000265322.7, OTTHUMT00000337277
      Conserved Domains (1) summary
      cd05369
      Location:16267
      TER_DECR_SDR_a; Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

      Range
      216031656..216081843 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024452998.1XP_024308766.1  peroxisomal trans-2-enoyl-CoA reductase isoform X1

      Conserved Domains (1) summary
      cl25409
      Location:1130
      SDR; Short-chain dehydrogenases/reductases (SDR)
    2. XM_024452999.1XP_024308767.1  peroxisomal trans-2-enoyl-CoA reductase isoform X2

      Conserved Domains (1) summary
      cl25409
      Location:2121
      SDR; Short-chain dehydrogenases/reductases (SDR)

    RNA

    1. XR_001738847.2 RNA Sequence

    2. XR_001738848.2 RNA Sequence

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