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    ST6GALNAC1 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 [ Homo sapiens (human) ]

    Gene ID: 55808, updated on 2-Oct-2018

    Summary

    Official Symbol
    ST6GALNAC1provided by HGNC
    Official Full Name
    ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1provided by HGNC
    Primary source
    HGNC:HGNC:23614
    See related
    Ensembl:ENSG00000070526 MIM:610138; Vega:OTTHUMG00000180369
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    STYI; SIAT7A; HSY11339; ST6GalNAcI
    Summary
    Glycosylation of proteins affects cell-cell interaction, interactions with the matrix, and the functions of intracellular molecules. ST6GALNAC1 transfers a sialic acid, N-acetylneuraminic acid (NeuAc), in an alpha-2,6 linkage to O-linked GalNAc residues. The cancer-associated sialyl-Tn (sTn) antigen is formed by ST6GALNAC1-catalyzed sialylation of GalNAc residues on mucins (Ikehara et al., 1999 [PubMed 10536037]; Sewell et al., 2006 [PubMed 16319059]).[supplied by OMIM, Mar 2008]
    Expression
    Biased expression in colon (RPKM 93.3), small intestine (RPKM 34.8) and 7 other tissues See more
    Orthologs

    Genomic context

    See ST6GALNAC1 in Genome Data Viewer
    Location:
    17q25.1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (76617769..76643838, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (74620838..74639894, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA host gene 16 Neighboring gene ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 Neighboring gene small nucleolar RNA, C/D box 1A Neighboring gene prothymosin alpha pseudogene 13 Neighboring gene RNA, U6 small nuclear 227, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity TAS
    Traceable Author Statement
    more info
     
    sialyltransferase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    oligosaccharide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein glycosylation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    sialylation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi membrane TAS
    Traceable Author Statement
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
    Names
    GalNAc alpha-2, 6-sialyltransferase I, long form
    SIAT7-A
    ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
    ST6 GalNAc alpha-2,6-sialyltransferase 1
    ST6GALNAC1, alpha-2,6-sialyltransferase 1
    ST6GalNAc I
    galNAc alpha-2,6-sialyltransferase I
    sialyltransferase 7 ((alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase) A
    sialyltransferase 7A
    NP_001276036.1
    NP_060884.1
    XP_011523297.1
    XP_011523298.1
    XP_016880331.1
    XP_016880332.1
    XP_016880333.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289107.1NP_001276036.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 isoform 2

      See identical proteins and their annotated locations for NP_001276036.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      BC063830, CB305371, DA594489
      Conserved Domains (1) summary
      pfam00777
      Location:171457
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
    2. NM_018414.4NP_060884.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 isoform 1

      See identical proteins and their annotated locations for NP_060884.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AY358918, CB305371, DA594489
      Consensus CDS
      CCDS11748.1
      UniProtKB/Swiss-Prot
      Q9NSC7
      Related
      ENSP00000156626.6, OTTHUMP00000264096, ENST00000156626.11, OTTHUMT00000450974
      Conserved Domains (1) summary
      pfam00777
      Location:303589
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    RNA

    1. NR_110309.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate coding exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AY358918, BC022462, CB305371, DA594489
      Related
      ENST00000359088.9, OTTHUMT00000450973

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

      Range
      76617769..76643838 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017024842.1XP_016880331.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 isoform X1

      Conserved Domains (1) summary
      pfam00777
      Location:303519
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
    2. XM_011524996.2XP_011523298.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 isoform X2

      Conserved Domains (1) summary
      pfam00777
      Location:303519
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
    3. XM_011524995.3XP_011523297.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 isoform X1

      Conserved Domains (1) summary
      pfam00777
      Location:303519
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
    4. XM_017024843.1XP_016880332.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 isoform X3

    5. XM_017024844.2XP_016880333.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 isoform X4

    RNA

    1. XR_001752559.2 RNA Sequence

      Related
      ENST00000592042.5
    2. XR_002958047.1 RNA Sequence

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