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    PPP4R3A protein phosphatase 4 regulatory subunit 3A [ Homo sapiens (human) ]

    Gene ID: 55671, updated on 3-Jun-2018
    Official Symbol
    PPP4R3Aprovided by HGNC
    Official Full Name
    protein phosphatase 4 regulatory subunit 3Aprovided by HGNC
    Primary source
    HGNC:HGNC:20219
    See related
    Ensembl:ENSG00000100796 MIM:610351; Vega:OTTHUMG00000171102
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    smk1; FLFL1; PP4R3; SMEK1; smk-1; PP4R3A; MSTP033; KIAA2010
    Expression
    Ubiquitous expression in bone marrow (RPKM 27.7), testis (RPKM 19.4) and 25 other tissues See more
    Orthologs
    See PPP4R3A in Genome Data Viewer
    Location:
    14q32.12
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 14 NC_000014.9 (91457481..91510554, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (91923955..91976898, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 88C Neighboring gene uncharacterized LOC105370624 Neighboring gene uncharacterized LOC105370625 Neighboring gene COX assembly mitochondrial protein homolog pseudogene Neighboring gene uncharacterized LOC101928957 Neighboring gene cation channel sperm associated auxiliary subunit beta Neighboring gene RNA polymerase III subunit G pseudogene 1

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Glucagon signaling pathway, organism-specific biosystem (from KEGG)
      Glucagon signaling pathway, organism-specific biosystemGlucagon is conventionally regarded as a counterregulatory hormone for insulin and plays a critical anti-hypoglycemic role by maintaining glucose homeostasis in both animals and humans. To increase ...
    • Glucagon signaling pathway, conserved biosystem (from KEGG)
      Glucagon signaling pathway, conserved biosystemGlucagon is conventionally regarded as a counterregulatory hormone for insulin and plays a critical anti-hypoglycemic role by maintaining glucose homeostasis in both animals and humans. To increase ...
    • Integrated Breast Cancer Pathway, organism-specific biosystem (from WikiPathways)
      Integrated Breast Cancer Pathway, organism-specific biosystemThis pathway incorporates the most important proteins for Breast Cancer. The Rp score from the Connectivity-Maps (C-Maps) webserver was used to determine the rank of the most important proteins in Br...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule organizing center IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    Preferred Names
    serine/threonine-protein phosphatase 4 regulatory subunit 3A
    Names
    SMEK homolog 1, suppressor of mek1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001284280.1NP_001271209.1  serine/threonine-protein phosphatase 4 regulatory subunit 3A isoform 1

      See identical proteins and their annotated locations for NP_001271209.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AB095930, AI608781, BC022778, BC028088
      Consensus CDS
      CCDS9895.1
      UniProtKB/Swiss-Prot
      Q6IN85
      UniProtKB/TrEMBL
      A0A024R6M2, Q8N6W1
      Related
      ENSP00000450864.1, OTTHUMP00000245082, ENST00000554684.5, OTTHUMT00000411664
      Conserved Domains (3) summary
      pfam04802
      Location:166357
      SMK-1; Component of IIS longevity pathway SMK-1
      cl17171
      Location:765
      PH-like; Pleckstrin homology-like domain
      cl26969
      Location:325402
      Vitellogenin_N; Lipoprotein amino terminal region
    2. NM_001284281.1NP_001271210.1  serine/threonine-protein phosphatase 4 regulatory subunit 3A isoform 3

      See identical proteins and their annotated locations for NP_001271210.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two alternate in-frame exons and uses an alternate in-frame splice site, compared to variant 3. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AI608781, BC022778, BC028088, BC038932
      Consensus CDS
      CCDS61532.1
      UniProtKB/Swiss-Prot
      Q6IN85
      UniProtKB/TrEMBL
      Q8N6W1
      Related
      ENSP00000450891.1, OTTHUMP00000245084, ENST00000555462.5, OTTHUMT00000411667
      Conserved Domains (3) summary
      pfam04802
      Location:66118
      SMK-1; Component of IIS longevity pathway SMK-1
      cl17171
      Location:798
      PH-like; Pleckstrin homology-like domain
      cl26969
      Location:86163
      Vitellogenin_N; Lipoprotein amino terminal region

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p12 Primary Assembly

      Range
      91457481..91510554 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005267842.2XP_005267899.1  serine/threonine-protein phosphatase 4 regulatory subunit 3A isoform X1

      See identical proteins and their annotated locations for XP_005267899.1

      UniProtKB/Swiss-Prot
      Q6IN85
      Related
      ENSP00000450883.1, OTTHUMP00000245083, ENST00000554943.5, OTTHUMT00000411665
      Conserved Domains (3) summary
      pfam04802
      Location:166357
      SMK-1; Component of IIS longevity pathway SMK-1
      cl17171
      Location:765
      PH-like; Pleckstrin homology-like domain
      cl26969
      Location:325402
      Vitellogenin_N; Lipoprotein amino terminal region

    RNA

    1. XR_001750421.2 RNA Sequence

    2. XR_943491.3 RNA Sequence

    3. XR_002957561.1 RNA Sequence

    4. XR_002957560.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_017936.3: Suppressed sequence

      Description
      NM_017936.3: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    2. NM_032560.4: Suppressed sequence

      Description
      NM_032560.4: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
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