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    TTC27 tetratricopeptide repeat domain 27 [ Homo sapiens (human) ]

    Gene ID: 55622, updated on 5-Aug-2018

    Summary

    Official Symbol
    TTC27provided by HGNC
    Official Full Name
    tetratricopeptide repeat domain 27provided by HGNC
    Primary source
    HGNC:HGNC:25986
    See related
    Ensembl:ENSG00000018699 Vega:OTTHUMG00000152134
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Ubiquitous expression in testis (RPKM 8.0), thyroid (RPKM 6.7) and 25 other tissues See more
    Orthologs

    Genomic context

    See TTC27 in Genome Data Viewer
    Location:
    2p22.3
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (32628020..32821051)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (32853087..33046118)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene baculoviral IAP repeat containing 6 Neighboring gene BIRC6 antisense RNA 2 Neighboring gene microRNA 558 Neighboring gene microRNA 4765 Neighboring gene long intergenic non-protein coding RNA 486 Neighboring gene uncharacterized LOC105374453 Neighboring gene latent transforming growth factor beta binding protein 1 Neighboring gene tRNA-yW synthesizing protein 1 homolog pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ20272

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    biological_process ND
    No biological Data available
    more info
     
    Component Evidence Code Pubs
    cellular_component ND
    No biological Data available
    more info
     

    General protein information

    Preferred Names
    tetratricopeptide repeat protein 27
    Names
    TPR repeat protein 27

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001193509.1NP_001180438.1  tetratricopeptide repeat protein 27 isoform 2

      See identical proteins and their annotated locations for NP_001180438.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses a different splice site in its first exon, which results in the use of a downstream, in-frame, start codon, compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus when it is compared to isoform 1.
      Source sequence(s)
      AK299196, BC001248, BI546117
      UniProtKB/Swiss-Prot
      Q6P3X3
      UniProtKB/TrEMBL
      B4DRC7
      Conserved Domains (3) summary
      sd00006
      Location:477505
      TPR; TPR repeat [structural motif]
      pfam07719
      Location:513544
      TPR_2; Tetratricopeptide repeat
      pfam13414
      Location:513575
      TPR_11; TPR repeat
    2. NM_017735.4NP_060205.3  tetratricopeptide repeat protein 27 isoform 1

      See identical proteins and their annotated locations for NP_060205.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
      Source sequence(s)
      BC001248, BC063791, BI546117
      Consensus CDS
      CCDS33176.1
      UniProtKB/Swiss-Prot
      Q6P3X3
      Related
      ENSP00000313953.4, OTTHUMP00000201272, ENST00000317907.8, OTTHUMT00000325395
      Conserved Domains (2) summary
      COG0457
      Location:475631
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:527555
      TPR; TPR repeat [structural motif]

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

      Range
      32628020..32821051
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011532958.2XP_011531260.1  tetratricopeptide repeat protein 27 isoform X1

      Conserved Domains (2) summary
      sd00006
      Location:527555
      TPR; TPR repeat [structural motif]
      pfam13414
      Location:526592
      TPR_11; TPR repeat
    2. XM_005264416.2XP_005264473.1  tetratricopeptide repeat protein 27 isoform X2

      Conserved Domains (3) summary
      sd00006
      Location:486514
      TPR; TPR repeat [structural motif]
      pfam07719
      Location:522553
      TPR_2; Tetratricopeptide repeat
      pfam13414
      Location:522584
      TPR_11; TPR repeat

    RNA

    1. XR_002959314.1 RNA Sequence

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