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    PRCC proline rich mitotic checkpoint control factor [ Homo sapiens (human) ]

    Gene ID: 5546, updated on 8-Jul-2021

    Summary

    Official Symbol
    PRCCprovided by HGNC
    Official Full Name
    proline rich mitotic checkpoint control factorprovided by HGNC
    Primary source
    HGNC:HGNC:9343
    See related
    Ensembl:ENSG00000143294 MIM:179755
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TPRC; RCCP1
    Summary
    This gene encodes a protein that may play a role in pre-mRNA splicing. Chromosomal translocations (X;1)(p11;q21) that result in fusion of this gene to TFE3 (GeneID 7030) have been associated with papillary renal cell carcinoma. A PRCC-TFE3 fusion protein is expressed in affected carcinomas and is likely associated with altered gene transactivation. This fusion protein has also been associated with disruption of the cell cycle.[provided by RefSeq, Aug 2010]
    Expression
    Ubiquitous expression in brain (RPKM 14.8), spleen (RPKM 14.1) and 25 other tissues See more
    Orthologs
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    Genomic context

    See PRCC in Genome Data Viewer
    Location:
    1q23.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (156767535..156800815)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (156737327..156770607)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L24 Neighboring gene heparin binding growth factor Neighboring gene Sharpr-MPRA regulatory region 3718 Neighboring gene SH2 domain containing 2A Neighboring gene neurotrophic receptor tyrosine kinase 1 Neighboring gene insulin receptor related receptor

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of papillary renal cell carcinoma protein (PRCC) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC4723, MGC17178

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    proline-rich protein PRCC
    Names
    PRCC, proline rich mitotic checkpoint control factor
    papillary renal cell carcinoma (translocation-associated)
    papillary renal cell carcinoma translocation-associated gene protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008138.1 RefSeqGene

      Range
      5054..38334
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_005973.5NP_005964.3  proline-rich protein PRCC

      See identical proteins and their annotated locations for NP_005964.3

      Status: REVIEWED

      Source sequence(s)
      BC004913, BC010450, BM423590
      Consensus CDS
      CCDS1157.1
      UniProtKB/Swiss-Prot
      Q92733
      UniProtKB/TrEMBL
      A0A0S2Z456, Q96FT4
      Related
      ENSP00000271526.4, ENST00000271526.9
      Conserved Domains (1) summary
      pfam10253
      Location:370491
      PRCC; Mitotic checkpoint regulator, MAD2B-interacting

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      156767535..156800815
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_199416.1: Suppressed sequence

      Description
      NM_199416.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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