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    COPRS coordinator of PRMT5 and differentiation stimulator [ Homo sapiens (human) ]

    Gene ID: 55352, updated on 11-Jun-2021

    Summary

    Official Symbol
    COPRSprovided by HGNC
    Official Full Name
    coordinator of PRMT5 and differentiation stimulatorprovided by HGNC
    Primary source
    HGNC:HGNC:28848
    See related
    Ensembl:ENSG00000172301
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TTP1; COPR5; C17orf79; HSA272196
    Expression
    Broad expression in testis (RPKM 66.1), brain (RPKM 19.5) and 22 other tissues See more
    Orthologs
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    Genomic context

    See COPRS in Genome Data Viewer
    Location:
    17q11.2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (31851871..31859244, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (30178890..30186263, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene GPR160 pseudogene 2 Neighboring gene Sharpr-MPRA regulatory region 4911 Neighboring gene UTP6 small subunit processome component Neighboring gene SUZ12 polycomb repressive complex 2 subunit Neighboring gene RNA, 5S ribosomal pseudogene 437

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ21119

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables histone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in histone H4-R3 methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in histone H4-R3 methylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in muscle organ development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    coordinator of PRMT5 and differentiation stimulator
    Names
    cooperator of PRMT5
    coordinator of PRMT5, differentiation stimulator

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001330176.2NP_001317105.1  coordinator of PRMT5 and differentiation stimulator isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC004253, BE899028, BM784600, BQ671018, CD557513
      Consensus CDS
      CCDS82100.1
      UniProtKB/TrEMBL
      H9KV77
      Related
      ENSP00000367901.2, ENST00000378634.6
      Conserved Domains (1) summary
      pfam15340
      Location:22172
      COPR5; Cooperator of PRMT5 family
    2. NM_018405.4NP_060875.2  coordinator of PRMT5 and differentiation stimulator isoform 1

      See identical proteins and their annotated locations for NP_060875.2

      Status: VALIDATED

      Source sequence(s)
      AF407672, BQ671018, DB472863
      Consensus CDS
      CCDS11268.1
      UniProtKB/Swiss-Prot
      Q9NQ92
      Related
      ENSP00000304327.6, ENST00000302362.11
      Conserved Domains (1) summary
      pfam15340
      Location:34184
      COPR5; Cooperator of PRMT5 family

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

      Range
      31851871..31859244 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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