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    RNLS renalase, FAD dependent amine oxidase [ Homo sapiens (human) ]

    Gene ID: 55328, updated on 2-Sep-2018

    Summary

    Official Symbol
    RNLSprovided by HGNC
    Official Full Name
    renalase, FAD dependent amine oxidaseprovided by HGNC
    Primary source
    HGNC:HGNC:25641
    See related
    Ensembl:ENSG00000184719 MIM:609360; Vega:OTTHUMG00000018692
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C10orf59; RENALASE
    Summary
    Renalase is a flavin adenine dinucleotide-dependent amine oxidase that is secreted into the blood from the kidney (Xu et al., 2005 [PubMed 15841207]).[supplied by OMIM, Mar 2008]
    Expression
    Low expression observed in reference dataset See more
    Orthologs

    Genomic context

    See RNLS in Genome Data Viewer
    Location:
    10q23.31
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 10 NC_000010.11 (88176052..88584480, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (90033621..90343611, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378415 Neighboring gene uncharacterized LOC105378416 Neighboring gene uncharacterized LOC101929727 Neighboring gene vomeronasal 1 receptor 55 pseudogene Neighboring gene lipase family member J Neighboring gene ribosomal protein L7 pseudogene 34 Neighboring gene lipase F, gastric type

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
    NHGRI GWA Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ11218

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    NADH binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    epinephrine binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    monoamine oxidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    oxidoreductase activity, acting on NAD(P)H IDA
    Inferred from Direct Assay
    more info
    PubMed 
    oxidoreductase activity, acting on NAD(P)H TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    NAD biosynthesis via nicotinamide riboside salvage pathway TAS
    Traceable Author Statement
    more info
     
    negative regulation of blood pressure IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of heart rate IDA
    Inferred from Direct Assay
    more info
    PubMed 
    oxidation-reduction process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to epinephrine IEA
    Inferred from Electronic Annotation
    more info
     
    response to ischemia IEA
    Inferred from Electronic Annotation
    more info
     
    response to salt IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
     
    extracellular space IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    renalase
    Names
    MAO-C
    alpha-NAD(P)H oxidase/anomerase
    monoamine oxidase-C
    NP_001026879.2
    NP_060833.1
    XP_005270003.1
    XP_005270004.1
    XP_005270005.1
    XP_005270006.1
    XP_005270007.1
    XP_011538226.1
    XP_011538229.1
    XP_016871869.1
    XP_016871870.1
    XP_016871871.1
    XP_016871872.1
    XP_016871873.1
    XP_016871874.1
    XP_024303831.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001031709.2NP_001026879.2  renalase isoform 1 precursor

      See identical proteins and their annotated locations for NP_001026879.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AA854849, AL353149, BC005364, BM978857, BP332262
      Consensus CDS
      CCDS31239.1
      UniProtKB/Swiss-Prot
      Q5VYX0
      Related
      ENSP00000332530.4, OTTHUMP00000020035, ENST00000331772.8, OTTHUMT00000049250
      Conserved Domains (3) summary
      COG3380
      Location:1342
      COG3380; Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]
      pfam13450
      Location:680
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
      cl21454
      Location:109226
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    2. NM_018363.3NP_060833.1  renalase isoform 2 precursor

      See identical proteins and their annotated locations for NP_060833.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (2) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AK002080, AL353149, BP332262
      Consensus CDS
      CCDS7388.1
      UniProtKB/Swiss-Prot
      Q5VYX0
      Related
      ENSP00000361015.3, OTTHUMP00000020034, ENST00000371947.7, OTTHUMT00000049249
      Conserved Domains (2) summary
      pfam13450
      Location:680
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
      cl21454
      Location:109226
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p12 Primary Assembly

      Range
      88176052..88584480 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017016382.2XP_016871871.1  renalase isoform X8

      UniProtKB/TrEMBL
      B4DJW3
      Conserved Domains (1) summary
      pfam13450
      Location:640
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
    2. XM_011539924.3XP_011538226.1  renalase isoform X1

      See identical proteins and their annotated locations for XP_011538226.1

      UniProtKB/Swiss-Prot
      Q5VYX0
      Conserved Domains (2) summary
      pfam13450
      Location:680
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
      cl21454
      Location:109226
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    3. XM_017016380.2XP_016871869.1  renalase isoform X1

      UniProtKB/Swiss-Prot
      Q5VYX0
      Conserved Domains (2) summary
      pfam13450
      Location:680
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
      cl21454
      Location:109226
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    4. XM_005269950.4XP_005270007.1  renalase isoform X8

      See identical proteins and their annotated locations for XP_005270007.1

      UniProtKB/TrEMBL
      B4DJW3
      Conserved Domains (1) summary
      pfam13450
      Location:640
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
    5. XM_017016384.2XP_016871873.1  renalase isoform X11

    6. XM_005269948.3XP_005270005.1  renalase isoform X6

      Conserved Domains (2) summary
      COG3380
      Location:41259
      COG3380; Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]
      pfam13450
      Location:640
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
    7. XM_024448063.1XP_024303831.1  renalase isoform X9

      Conserved Domains (2) summary
      pfam13450
      Location:640
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
      cl27536
      Location:41208
      COG1233; Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and catabolism]
    8. XM_005269947.2XP_005270004.1  renalase isoform X5

      Conserved Domains (2) summary
      pfam13450
      Location:680
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
      cl21454
      Location:109226
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    9. XM_005269946.2XP_005270003.1  renalase isoform X2

      See identical proteins and their annotated locations for XP_005270003.1

      Conserved Domains (2) summary
      pfam13450
      Location:680
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
      cl21454
      Location:109226
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    10. XM_017016385.1XP_016871874.1  renalase isoform X12

    11. XM_011539927.3XP_011538229.1  renalase isoform X3

      Conserved Domains (2) summary
      pfam13450
      Location:680
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
      cl21454
      Location:109226
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    12. XM_017016381.2XP_016871870.1  renalase isoform X4

    13. XM_005269949.5XP_005270006.1  renalase isoform X7

      Conserved Domains (2) summary
      pfam13450
      Location:680
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
      cl21454
      Location:109226
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    14. XM_017016383.2XP_016871872.1  renalase isoform X10

      Related
      ENSP00000387577.2, ENST00000437752.2

    RNA

    1. XR_001747122.2 RNA Sequence

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