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    TIPIN TIMELESS interacting protein [ Homo sapiens (human) ]

    Gene ID: 54962, updated on 9-Sep-2018

    Summary

    Official Symbol
    TIPINprovided by HGNC
    Official Full Name
    TIMELESS interacting proteinprovided by HGNC
    Primary source
    HGNC:HGNC:30750
    See related
    Ensembl:ENSG00000075131 MIM:610716; Vega:OTTHUMG00000133188
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The protein encoded by this gene is part of the replisome complex, a group of proteins that support DNA replication. It binds TIM, which is involved in circadian rhythm regulation, and aids in protecting cells against DNA damage and stress. Two pseudogenes and two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
    Expression
    Broad expression in testis (RPKM 3.8), lymph node (RPKM 1.8) and 24 other tissues See more
    Orthologs

    Genomic context

    See TIPIN in Genome Data Viewer
    Location:
    15q22.31
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 15 NC_000015.10 (66334974..66387273, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (66629008..66679074, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene multiple EGF like domains 11 Neighboring gene microRNA 4311 Neighboring gene uncharacterized LOC105370868 Neighboring gene DIS3 like exosome 3'-5' exoribonuclease Neighboring gene small Cajal body-specific RNA 14 Neighboring gene ribosomal protein L9 pseudogene 25 Neighboring gene mitogen-activated protein kinase kinase 1 Neighboring gene ATP synthase membrane subunit f pseudogene 6 Neighboring gene ribosomal protein L35a pseudogene 32

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • DNA Double-Strand Break Repair, organism-specific biosystem (from REACTOME)
      DNA Double-Strand Break Repair, organism-specific biosystemNumerous types of DNA damage can occur within a cell due to the endogenous production of oxygen free radicals, normal alkylation reactions, or exposure to exogenous radiations and chemicals. Double-s...
    • DNA Repair, organism-specific biosystem (from REACTOME)
      DNA Repair, organism-specific biosystemDNA repair is a phenomenal multi-enzyme, multi-pathway system required to ensure the integrity of the cellular genome. Living organisms are constantly exposed to harmful metabolic by-products, enviro...
    • HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA), organism-specific biosystem (from REACTOME)
      HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA), organism-specific biosystemHomology directed repair (HDR) of replication-independent DNA double strand breaks (DSBs) via homologous recombination repair (HRR) or single strand annealing (SSA) requires the activation of ATM fol...
    • Homology Directed Repair, organism-specific biosystem (from REACTOME)
      Homology Directed Repair, organism-specific biosystemHomology directed repair (HDR) of DNA double strand breaks (DSBs) requires resection of DNA DSB ends. Resection creates 3'-ssDNA overhangs which then anneal with a homologous DNA sequence. This homol...
    • Processing of DNA double-strand break ends, organism-specific biosystem (from REACTOME)
      Processing of DNA double-strand break ends, organism-specific biosystemHomology directed repair (HDR) through homologous recombination (HRR) or single strand annealing (SSA) requires extensive resection of DNA double strand break (DSB) ends (Thompson and Limoli 2003, Ci...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ20516

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    DNA replication checkpoint IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    DNA replication checkpoint IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell cycle phase transition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    intra-S DNA damage checkpoint IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of nuclear cell cycle DNA replication TAS
    Traceable Author Statement
    more info
    PubMed 
    replication fork arrest IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    replication fork protection IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    response to UV IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    nuclear chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    replication fork protection complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    TIMELESS-interacting protein
    Names
    CSM3 homolog

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289986.1NP_001276915.1  TIMELESS-interacting protein isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon compared to variant 1. This difference causes translation initiation at a downstream AUG and results in an isoform (2) with a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC055855, AK000523, AK299233, BU596053, BU688750
      UniProtKB/Swiss-Prot
      Q9BVW5
      UniProtKB/TrEMBL
      B4DRF3
      Conserved Domains (1) summary
      pfam07962
      Location:247
      Swi3; Replication Fork Protection Component Swi3
    2. NM_017858.2NP_060328.2  TIMELESS-interacting protein isoform 1

      See identical proteins and their annotated locations for NP_060328.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC055855, BC000870, BU596053, BU688750
      Consensus CDS
      CCDS10215.1
      UniProtKB/Swiss-Prot
      Q9BVW5
      Related
      ENSP00000261881.4, OTTHUMP00000164244, ENST00000261881.8, OTTHUMT00000256897
      Conserved Domains (1) summary
      pfam07962
      Location:66148
      Swi3; Replication Fork Protection Component Swi3

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p12 Primary Assembly

      Range
      66334974..66387273 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017022391.2XP_016877880.1  TIMELESS-interacting protein isoform X3

      Conserved Domains (1) summary
      pfam07962
      Location:247
      Swi3; Replication Fork Protection Component Swi3
    2. XM_024449974.1XP_024305742.1  TIMELESS-interacting protein isoform X3

      Conserved Domains (1) summary
      pfam07962
      Location:247
      Swi3; Replication Fork Protection Component Swi3
    3. XM_024449973.1XP_024305741.1  TIMELESS-interacting protein isoform X3

      Conserved Domains (1) summary
      pfam07962
      Location:247
      Swi3; Replication Fork Protection Component Swi3
    4. XM_005254521.3XP_005254578.2  TIMELESS-interacting protein isoform X1

      Conserved Domains (1) summary
      pfam07962
      Location:113195
      Swi3; Replication Fork Protection Component Swi3
    5. XM_024449972.1XP_024305740.1  TIMELESS-interacting protein isoform X2

      Related
      ENSP00000457406.1, ENST00000562124.5
      Conserved Domains (1) summary
      pfam07962
      Location:66148
      Swi3; Replication Fork Protection Component Swi3
    6. XM_024449971.1XP_024305739.1  TIMELESS-interacting protein isoform X2

      Conserved Domains (1) summary
      pfam07962
      Location:66148
      Swi3; Replication Fork Protection Component Swi3
    7. XM_017022390.1XP_016877879.1  TIMELESS-interacting protein isoform X2

      UniProtKB/Swiss-Prot
      Q9BVW5
      Conserved Domains (1) summary
      pfam07962
      Location:66148
      Swi3; Replication Fork Protection Component Swi3
    8. XM_011521743.1XP_011520045.1  TIMELESS-interacting protein isoform X2

      See identical proteins and their annotated locations for XP_011520045.1

      UniProtKB/Swiss-Prot
      Q9BVW5
      Conserved Domains (1) summary
      pfam07962
      Location:66148
      Swi3; Replication Fork Protection Component Swi3
    9. XM_005254522.4XP_005254579.1  TIMELESS-interacting protein isoform X2

      See identical proteins and their annotated locations for XP_005254579.1

      UniProtKB/Swiss-Prot
      Q9BVW5
      Conserved Domains (1) summary
      pfam07962
      Location:66148
      Swi3; Replication Fork Protection Component Swi3
    10. XM_006720594.3XP_006720657.1  TIMELESS-interacting protein isoform X2

      See identical proteins and their annotated locations for XP_006720657.1

      UniProtKB/Swiss-Prot
      Q9BVW5
      Conserved Domains (1) summary
      pfam07962
      Location:66148
      Swi3; Replication Fork Protection Component Swi3
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