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    ADPRHL2 ADP-ribosylhydrolase like 2 [ Homo sapiens (human) ]

    Gene ID: 54936, updated on 3-Jun-2018
    Official Symbol
    ADPRHL2provided by HGNC
    Official Full Name
    ADP-ribosylhydrolase like 2provided by HGNC
    Primary source
    HGNC:HGNC:21304
    See related
    Ensembl:ENSG00000116863 MIM:610624; Vega:OTTHUMG00000007628
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ARH3
    Summary
    This gene encodes a member of the ADP-ribosylglycohydrolase family. The encoded enzyme catalyzes the removal of ADP-ribose from ADP-ribosylated proteins. This enzyme localizes to the mitochondria, in addition to the nucleus and cytoplasm.[provided by RefSeq, Feb 2009]
    Expression
    Ubiquitous expression in testis (RPKM 14.2), lung (RPKM 13.1) and 25 other tissues See more
    Orthologs
    See ADPRHL2 in Genome Data Viewer
    Location:
    1p34.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (36088852..36093932)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (36554453..36559533)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene magnesium transporter 1 pseudogene Neighboring gene tektin 2 Neighboring gene collagen type VIII alpha 2 chain Neighboring gene trafficking protein particle complex 3 Neighboring gene MAP7 domain containing 1

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ20446

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    poly(ADP-ribose) glycohydrolase activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    cellular response to superoxide IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    mitochondrial matrix TAS
    Traceable Author Statement
    more info
     
    mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nuclear body IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Preferred Names
    poly(ADP-ribose) glycohydrolase ARH3
    Names
    ADP-ribosylarginine hydrolase like 2
    ADP-ribosylhydrolase 3
    [Protein ADP-ribosylarginine] hydrolase-like protein 2
    protein ADP-ribosylarginine hydrolase-like protein 2
    NP_060295.1
    XP_011539938.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017825.2NP_060295.1  poly(ADP-ribose) glycohydrolase ARH3

      See identical proteins and their annotated locations for NP_060295.1

      Status: REVIEWED

      Source sequence(s)
      BC014169, DC365461
      Consensus CDS
      CCDS402.1
      UniProtKB/Swiss-Prot
      Q9NX46
      Related
      ENSP00000362273.4, OTTHUMP00000008926, ENST00000373178.4, OTTHUMT00000020199
      Conserved Domains (1) summary
      cl00614
      Location:22339
      ADP_ribosyl_GH; ADP-ribosylglycohydrolase

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

      Range
      36088852..36093932
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011541636.2XP_011539938.1  poly(ADP-ribose) glycohydrolase ARH3 isoform X1

      See identical proteins and their annotated locations for XP_011539938.1

      UniProtKB/TrEMBL
      B7ZAN4
      Conserved Domains (1) summary
      cl00614
      Location:1185
      ADP_ribosyl_GH; ADP-ribosylglycohydrolase
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