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    ST7L suppression of tumorigenicity 7 like [ Homo sapiens (human) ]

    Gene ID: 54879, updated on 5-Aug-2018

    Summary

    Official Symbol
    ST7Lprovided by HGNC
    Official Full Name
    suppression of tumorigenicity 7 likeprovided by HGNC
    Primary source
    HGNC:HGNC:18441
    See related
    Ensembl:ENSG00000007341 MIM:617640; Vega:OTTHUMG00000011753
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ST7R; STLR; FAM4B
    Summary
    This gene was identified by its similarity to the ST7 tumor suppressor gene found in the chromosome 7q31 region. This gene is clustered in a tail-to-tail manner with the WNT2B gene in a chromosomal region known to be deleted and rearranged in a variety of cancers. Several transcript variants encoding many different isoforms have been described, but some have not been fully characterized. [provided by RefSeq, Feb 2011]
    Expression
    Broad expression in testis (RPKM 6.6), skin (RPKM 3.2) and 24 other tissues See more
    Orthologs

    Genomic context

    See ST7L in Genome Data Viewer
    Location:
    1p13.2
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (112517444..112619881, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (113066140..113162040, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene CTTNBP2 N-terminal like Neighboring gene microRNA 4256 Neighboring gene Wnt family member 2B Neighboring gene mitochondrial ribosomal protein L53 pseudogene 1 Neighboring gene capping actin protein of muscle Z-line subunit alpha 1 Neighboring gene RNA, U7 small nuclear 70 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians.
    NHGRI GWA Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ11657, FLJ20284

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    negative regulation of cell growth ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    suppressor of tumorigenicity 7 protein-like
    Names
    ST7-related protein
    tumor suppressor ST7 like

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001308264.1NP_001295193.1  suppressor of tumorigenicity 7 protein-like isoform 7

      See identical proteins and their annotated locations for NP_001295193.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) contains an alternate 5' terminal exon and lacks an alternate exon in its 5' UTR. This variant represents translation initiation at a downstream start codon compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream start codon to encode an isoform (7) that has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AB081317, AK097837, BC047392, BX537988, BX538338
      Consensus CDS
      CCDS76189.1
      UniProtKB/Swiss-Prot
      Q8TDW4
      Related
      ENSP00000358683.1, OTTHUMP00000013497, ENST00000369669.5, OTTHUMT00000032514
      Conserved Domains (1) summary
      cd11557
      Location:1355
      ST7; Suppression of tumorigenicity 7
    2. NM_017744.4NP_060214.2  suppressor of tumorigenicity 7 protein-like isoform 1

      See identical proteins and their annotated locations for NP_060214.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AB081317, AL109932, BX538338, CD358134
      Consensus CDS
      CCDS848.1
      UniProtKB/Swiss-Prot
      Q8TDW4
      Related
      ENSP00000350734.4, OTTHUMP00000013490, ENST00000358039.8, OTTHUMT00000032504
      Conserved Domains (1) summary
      pfam04184
      Location:43552
      ST7; ST7 protein
    3. NM_138727.3NP_620055.1  suppressor of tumorigenicity 7 protein-like isoform 2

      See identical proteins and their annotated locations for NP_620055.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame segment, compared to variant 1, resulting in an isoform (2) that is missing an internal region, as compared to isoform 1.
      Source sequence(s)
      AB081318, AL109932, BX538338, CD358134
      Consensus CDS
      CCDS849.1
      UniProtKB/Swiss-Prot
      Q8TDW4
      Related
      ENSP00000417140.1, OTTHUMP00000013491, ENST00000490067.5, OTTHUMT00000032505
      Conserved Domains (1) summary
      cd11557
      Location:69521
      ST7; Suppression of tumorigenicity 7
    4. NM_138728.2NP_620056.1  suppressor of tumorigenicity 7 protein-like isoform 3

      See identical proteins and their annotated locations for NP_620056.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame segment, compared to variant 1, resulting in an isoform (3) that is missing an internal region, as compared to isoform 1.
      Source sequence(s)
      AB081319, AL109932, BX538338, CD358134
      Consensus CDS
      CCDS850.1
      UniProtKB/Swiss-Prot
      Q8TDW4
      Related
      ENSP00000353972.4, OTTHUMP00000013492, ENST00000360743.8, OTTHUMT00000032506
      Conserved Domains (1) summary
      cd11557
      Location:72507
      ST7; Suppression of tumorigenicity 7
    5. NM_138729.3NP_620057.1  suppressor of tumorigenicity 7 protein-like isoform 4

      See identical proteins and their annotated locations for NP_620057.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 3' coding region and 3' UTR, when compared to variant 1, resulting in an isoform (4) that has a distinct and shorter C-terminus, as compared to isoform 1.
      Source sequence(s)
      AB081320, BC027898, CD358134
      Consensus CDS
      CCDS852.1
      UniProtKB/Swiss-Prot
      Q8TDW4
      Related
      ENSP00000345312.7, OTTHUMP00000013493, ENST00000343210.11, OTTHUMT00000032507
      Conserved Domains (1) summary
      cd11557
      Location:72538
      ST7; Suppression of tumorigenicity 7

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

      Range
      112517444..112619881 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011541628.2XP_011539930.1  suppressor of tumorigenicity 7 protein-like isoform X2

      Conserved Domains (1) summary
      cd11557
      Location:72538
      ST7; Suppression of tumorigenicity 7
    2. XM_017001536.1XP_016857025.1  suppressor of tumorigenicity 7 protein-like isoform X7

    3. XM_011541631.3XP_011539933.1  suppressor of tumorigenicity 7 protein-like isoform X5

      See identical proteins and their annotated locations for XP_011539933.1

      Conserved Domains (1) summary
      cd11557
      Location:12416
      ST7; Suppression of tumorigenicity 7
    4. XM_005270964.3XP_005271021.1  suppressor of tumorigenicity 7 protein-like isoform X5

      See identical proteins and their annotated locations for XP_005271021.1

      Conserved Domains (1) summary
      cd11557
      Location:12416
      ST7; Suppression of tumorigenicity 7
    5. XM_024447771.1XP_024303539.1  suppressor of tumorigenicity 7 protein-like isoform X8

      Conserved Domains (1) summary
      cl19051
      Location:2254
      ST7; Suppression of tumorigenicity 7
    6. XM_005270963.4XP_005271020.1  suppressor of tumorigenicity 7 protein-like isoform X5

      See identical proteins and their annotated locations for XP_005271020.1

      Conserved Domains (1) summary
      cd11557
      Location:12416
      ST7; Suppression of tumorigenicity 7
    7. XM_011541629.2XP_011539931.1  suppressor of tumorigenicity 7 protein-like isoform X4

      Conserved Domains (1) summary
      cd11557
      Location:16482
      ST7; Suppression of tumorigenicity 7
    8. XM_011541627.2XP_011539929.1  suppressor of tumorigenicity 7 protein-like isoform X1

      Conserved Domains (1) summary
      cd11557
      Location:72538
      ST7; Suppression of tumorigenicity 7
    9. XM_017001534.1XP_016857023.1  suppressor of tumorigenicity 7 protein-like isoform X3

    10. XM_017001535.1XP_016857024.1  suppressor of tumorigenicity 7 protein-like isoform X6

    RNA

    1. XR_946674.2 RNA Sequence

    2. XR_001737249.1 RNA Sequence

    3. XR_001737251.1 RNA Sequence

    4. XR_001737252.1 RNA Sequence

    5. XR_246280.4 RNA Sequence

    6. XR_946675.2 RNA Sequence

    7. XR_001737250.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_198327.1: Suppressed sequence

      Description
      NM_198327.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate and the protein also lacks homolog support.
    2. NM_198328.1: Suppressed sequence

      Description
      NM_198328.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate and the protein also lacks homolog support.
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