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    SNRK SNF related kinase [ Homo sapiens (human) ]

    Gene ID: 54861, updated on 3-Jun-2018
    Official Symbol
    SNRKprovided by HGNC
    Official Full Name
    SNF related kinaseprovided by HGNC
    Primary source
    HGNC:HGNC:30598
    See related
    Ensembl:ENSG00000163788 MIM:612760; Vega:OTTHUMG00000156491
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HSNFRK
    Summary
    SNRK is a member of the sucrose nonfermenting (SNF)-related kinase family of serine/threonine kinases (Kertesz et al., 2002 [PubMed 12234663]).[supplied by OMIM, Apr 2009]
    Expression
    Ubiquitous expression in bone marrow (RPKM 23.2), thyroid (RPKM 20.1) and 25 other tissues See more
    Orthologs
    See SNRK in Genome Data Viewer
    Location:
    3p22.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (43286512..43351143)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (43328004..43392635)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory regions 3209 and 6245 Neighboring gene uncharacterized LOC105377052 Neighboring gene RNA, 7SL, cytoplasmic 517, pseudogene Neighboring gene SNRK antisense RNA 1 Neighboring gene anoctamin 10 Neighboring gene uncharacterized LOC107986080 Neighboring gene ribosomal protein L18a pseudogene

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    NHGRI GWA Catalog
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ20224, KIAA0096, DKFZp779A1866

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    myeloid cell differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Preferred Names
    SNF-related serine/threonine-protein kinase
    Names
    SNF-1 related kinase
    SNF1-related kinase
    NP_001094064.1
    NP_001317679.1
    NP_060189.3
    XP_005265302.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100594.1NP_001094064.1  SNF-related serine/threonine-protein kinase isoform 1

      See identical proteins and their annotated locations for NP_001094064.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AK025449, BC071567, D43636, DA769463, DB080037
      Consensus CDS
      CCDS43075.1
      UniProtKB/Swiss-Prot
      Q9NRH2
      UniProtKB/TrEMBL
      A0A024R2Y6
      Related
      ENSP00000411375.2, OTTHUMP00000209955, ENST00000429705.6, OTTHUMT00000344323
      Conserved Domains (3) summary
      smart00220
      Location:16269
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14339
      Location:288335
      UBA_SNRK; UBA domain of SNF-related serine/threonine-protein kinase (SNRK) and similar proteins mainly found in metazoa
      cd14074
      Location:12269
      STKc_SNRK; Catalytic domain of the Serine/Threonine Kinase, SNF1-related kinase
    2. NM_001330750.1NP_001317679.1  SNF-related serine/threonine-protein kinase isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which is shorter at the N-terminus, compared to isoform 1.
      Source sequence(s)
      AK025449, AK291360, AK295187, D43636
      Consensus CDS
      CCDS82759.1
      UniProtKB/Swiss-Prot
      Q9NRH2
      UniProtKB/TrEMBL
      A8K5P5, B4DHM9, E7EUC4
      Related
      ENSP00000409516.1, ENST00000437827.1
      Conserved Domains (2) summary
      cd14339
      Location:82129
      UBA_SNRK; UBA domain of SNF-related serine/threonine-protein kinase (SNRK) and similar proteins mainly found in metazoa
      cl21453
      Location:163
      PKc_like; Protein Kinases, catalytic domain
    3. NM_017719.4NP_060189.3  SNF-related serine/threonine-protein kinase isoform 1

      See identical proteins and their annotated locations for NP_060189.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AK025449, BP281284, D43636, DA769463, DB080037
      Consensus CDS
      CCDS43075.1
      UniProtKB/Swiss-Prot
      Q9NRH2
      UniProtKB/TrEMBL
      A0A024R2Y6
      Related
      ENSP00000296088.7, OTTHUMP00000209957, ENST00000296088.11, OTTHUMT00000344325
      Conserved Domains (3) summary
      smart00220
      Location:16269
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14339
      Location:288335
      UBA_SNRK; UBA domain of SNF-related serine/threonine-protein kinase (SNRK) and similar proteins mainly found in metazoa
      cd14074
      Location:12269
      STKc_SNRK; Catalytic domain of the Serine/Threonine Kinase, SNF1-related kinase

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p12 Primary Assembly

      Range
      43286512..43351143
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005265245.3XP_005265302.1  SNF-related serine/threonine-protein kinase isoform X1

      See identical proteins and their annotated locations for XP_005265302.1

      UniProtKB/Swiss-Prot
      Q9NRH2
      UniProtKB/TrEMBL
      A0A024R2Y6
      Related
      ENSP00000401246.1, OTTHUMP00000209954, ENST00000454177.5, OTTHUMT00000344322
      Conserved Domains (3) summary
      smart00220
      Location:16269
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14339
      Location:288335
      UBA_SNRK; UBA domain of SNF-related serine/threonine-protein kinase (SNRK) and similar proteins mainly found in metazoa
      cd14074
      Location:12269
      STKc_SNRK; Catalytic domain of the Serine/Threonine Kinase, SNF1-related kinase
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