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    RC3H2 ring finger and CCCH-type domains 2 [ Homo sapiens (human) ]

    Gene ID: 54542, updated on 7-Oct-2018

    Summary

    Official Symbol
    RC3H2provided by HGNC
    Official Full Name
    ring finger and CCCH-type domains 2provided by HGNC
    Primary source
    HGNC:HGNC:21461
    See related
    Ensembl:ENSG00000056586 MIM:615231; Vega:OTTHUMG00000020632
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MNAB; RNF164
    Expression
    Ubiquitous expression in lymph node (RPKM 7.8), testis (RPKM 7.6) and 25 other tissues See more
    Orthologs

    Genomic context

    See RC3H2 in Genome Data Viewer
    Location:
    9q33.2
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 9 NC_000009.12 (122844565..122905351, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (125606835..125667562, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene phosducin like Neighboring gene keratin 18 pseudogene 67 Neighboring gene small nucleolar RNA, C/D box 90 Neighboring gene zinc finger and BTB domain containing 6 Neighboring gene zinc finger and BTB domain containing 26

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ20301, FLJ20713, MGC52176

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA-binding transcription factor activity, RNA polymerase II-specific ISM
    Inferred from Sequence Model
    more info
    PubMed 
    RNA binding HDA PubMed 
    RNA stem-loop binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    double-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mRNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    B cell homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    T cell homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    T cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    T cell receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    T follicular helper cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    limb development IEA
    Inferred from Electronic Annotation
    more info
     
    lung alveolus development IEA
    Inferred from Electronic Annotation
    more info
     
    lymph node development IEA
    Inferred from Electronic Annotation
    more info
     
    multicellular organism growth IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of T-helper 17 cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of NIK/NF-kappaB signaling IEA
    Inferred from Electronic Annotation
    more info
     
    post-embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    posttranscriptional regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    protein polyubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein polyubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of miRNA metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    spleen development IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    P-body IEA
    Inferred from Electronic Annotation
    more info
     
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    roquin-2
    Names
    RING finger protein 164
    RING-type E3 ubiquitin transferase Roquin-2
    membrane associated DNA binding protein
    membrane-associated nucleic acid-binding protein
    ring finger and CCCH-type zinc finger domain-containing protein 2
    ring finger and CCCH-type zinc finger domains 2
    NP_001094058.1
    NP_001341407.1
    NP_001341408.1
    NP_001341411.1
    NP_001341415.1
    NP_061323.2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100588.2NP_001094058.1  roquin-2 isoform 1

      See identical proteins and their annotated locations for NP_001094058.1

      Status: VALIDATED

      Source sequence(s)
      AC007066, AL359512
      Consensus CDS
      CCDS43874.1
      UniProtKB/Swiss-Prot
      Q9HBD1
      UniProtKB/TrEMBL
      A0A024R899
      Related
      ENSP00000349783.2, ENST00000357244.6
      Conserved Domains (2) summary
      pfam00642
      Location:411437
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam14634
      Location:1455
      zf-RING_5; zinc-RING finger domain
    2. NM_001354478.1NP_001341407.1  roquin-2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC007066, AL359512
      Conserved Domains (3) summary
      pfam00642
      Location:411437
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      cd16638
      Location:1154
      mRING-HC-C3HC3D_Roquin; Modified RING finger, HC subclass (C3HC3D-type), found in Roquin-1, Roquin-2, and similar proteins
      cl25751
      Location:536798
      DUF4045; Domain of unknown function (DUF4045)
    3. NM_001354479.1NP_001341408.1  roquin-2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC007066, AL359512
      Conserved Domains (3) summary
      pfam00642
      Location:411437
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      cd16638
      Location:1154
      mRING-HC-C3HC3D_Roquin; Modified RING finger, HC subclass (C3HC3D-type), found in Roquin-1, Roquin-2, and similar proteins
      cl28087
      Location:530766
      FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]
    4. NM_001354482.1NP_001341411.1  roquin-2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC007066, AL359512
      Conserved Domains (3) summary
      pfam00642
      Location:411437
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      cd16638
      Location:1154
      mRING-HC-C3HC3D_Roquin; Modified RING finger, HC subclass (C3HC3D-type), found in Roquin-1, Roquin-2, and similar proteins
      cl25751
      Location:536798
      DUF4045; Domain of unknown function (DUF4045)
    5. NM_001354486.1NP_001341415.1  roquin-2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC007066, BC044642
      Consensus CDS
      CCDS87685.1
      Related
      ENSP00000335150.5, ENST00000335387.9
      Conserved Domains (2) summary
      pfam00642
      Location:411437
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      cd16638
      Location:1154
      mRING-HC-C3HC3D_Roquin; Modified RING finger, HC subclass (C3HC3D-type), found in Roquin-1, Roquin-2, and similar proteins
    6. NM_018835.3NP_061323.2  roquin-2 isoform 2

      See identical proteins and their annotated locations for NP_061323.2

      Status: VALIDATED

      Source sequence(s)
      AC007066, AL359512, AW291376
      Consensus CDS
      CCDS48014.1
      UniProtKB/Swiss-Prot
      Q9HBD1
      Related
      ENSP00000411767.1, OTTHUMP00000022077, ENST00000423239.6
      Conserved Domains (2) summary
      pfam00642
      Location:411437
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam14634
      Location:1455
      zf-RING_5; zinc-RING finger domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p12 Primary Assembly

      Range
      122844565..122905351 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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