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    TAS2R5 taste 2 receptor member 5 [ Homo sapiens (human) ]

    Gene ID: 54429, updated on 23-May-2018
    Official Symbol
    TAS2R5provided by HGNC
    Official Full Name
    taste 2 receptor member 5provided by HGNC
    Primary source
    HGNC:HGNC:14912
    See related
    Ensembl:ENSG00000127366 MIM:605062; Vega:OTTHUMG00000157632
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    T2R5
    Summary
    This gene encodes a bitter taste receptor; bitter taste receptors are members of the G protein-coupled receptor superfamily and are specifically expressed by taste receptor cells of the tongue and palate epithelia. Each of these apparently intronless taste receptor genes encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes on chromosome 7 and is genetically linked to loci that influence bitter perception. [provided by RefSeq, Jul 2008]
    Orthologs
    See TAS2R5 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 7 NC_000007.14 (141790217..141791366)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (141487129..141491338)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene taste 2 receptor member 4 Neighboring gene taste 2 receptor member 6 pseudogene Neighboring gene MT-CO1 pseudogene 55 Neighboring gene MT-ND2 pseudogene 5

    Related articles in PubMed

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    • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • GPCR ligand binding, organism-specific biosystem (from REACTOME)
      GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
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    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
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    • Taste transduction, organism-specific biosystem (from KEGG)
      Taste transduction, organism-specific biosystemFive basic tastes are recognized by humans and most other animals - bitter, sweet, sour, salty and umami. In vertebrates, taste stimuli are detected by taste receptor cells (TRCs). At least three dis...
    • Taste transduction, conserved biosystem (from KEGG)
      Taste transduction, conserved biosystemFive basic tastes are recognized by humans and most other animals - bitter, sweet, sour, salty and umami. In vertebrates, taste stimuli are detected by taste receptor cells (TRCs). At least three dis...

    Markers

    Homology

    Clone Names

    • MGC126635, MGC126637

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    G-protein coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    bitter taste receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    bitter taste receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    taste receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    integral component of membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integral component of membrane IC
    Inferred by Curator
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    taste receptor type 2 member 5
    Names
    taste receptor, type 2, member 5

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018980.2NP_061853.1  taste receptor type 2 member 5

      See identical proteins and their annotated locations for NP_061853.1

      Status: REVIEWED

      Source sequence(s)
      AW881072, BC095522
      Consensus CDS
      CCDS5869.1
      UniProtKB/Swiss-Prot
      Q9NYW4
      UniProtKB/TrEMBL
      A4D1U0, Q502V5
      Related
      ENSP00000247883.4, OTTHUMP00000212310, ENST00000247883.5, OTTHUMT00000349283
      Conserved Domains (1) summary
      pfam05296
      Location:1290
      TAS2R; Taste receptor protein (TAS2R)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p12 Primary Assembly

      Range
      141790217..141791366
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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